Gaining from Improved Dairy Cow Nutrition: Economic, environmental and animal health benefits

A majority of UK dairy herds have the potential to increase profitability by improving the ration of their cows. This paper reports that gains averaging around £100 per cow have been made within one year of adopting the Keenan Hi-Fibre ration by 239 UK herds in 2006 and 2007. Larger gains have been made by herds in France. The key performance indicator underlying these gains is Feed Conversion Efficiency, whereby the same, or even a smaller amount of Dry Matter Intake generates higher yields per cow. Importantly, the gains are associated with large improvements in animal health and reductions in greenhouse gases per litre of milk produced.Feed conversion efficiency, cattle nutrition, greenhouse gas emissions, animal health., Livestock Production/Industries,

Effects of Water-Level Management on Nesting Success of Common Loons

Water-level management is widespread and illustrates how contemporary climate can interact directly and indirectly with numerous biological and abiotic factors to influence reproductive success of wildlife species. We studied common loons, an iconic waterbird sensitive to timing and magnitude of waterlevel changes during the breeding season, using a before-after-control-impact design on large lakes in Voyageurs National Park (Minnesota, USA), to assess the effect of anthropogenic changes in hydroregime on their nesting success and productivity. We examined multiple competing a priori hypotheses in an information-theoretic framework, and predicted that magnitude of changes in loon productivity would be greater in the Namakan Reservoir, where water-level management was altered to mimic a more natural hydroregime, than in Rainy Lake, where management remained relatively unchanged. We determined outcomes from 278 nests during 2004–2006 by performing boat-based visits every 3–5 days, and measuring hydrologic, vegetative, and microtopographic covariates. Relative to comparably collected data for 260 total loon pairs during 1983–1986, productivity (chicks hatched/territorial pair) increased 95% in the Namakan Reservoir between the 2 time periods. Nest success declined in both lakes over the 2 study periods but less so in the Namakan Reservoir than in Rainy Lake. Flooding was a primary cause of nest failures (though second nests were less likely to flood). Nest predation appears to have increased considerably between the 2 study periods. Top-ranked models suggested that timing of nest initiation, probability of nest flooding, probability of nest stranding, and probability of nest success were each related to 2–4 factors, including date of initiation, timing of initiation relative to peak water levels, changes in the elevation of the nest edge, maximum waterlevel change between initiation and peak water levels, and maximum water-level change between initiation and nest outcome. The top model for all variables except stranding each garnered \u3e82% of total model weight. Results demonstrate that water-level management can be altered to benefit productivity of common loons. However, nuanced interactions between land-use change, invasive species, human development, recreation, climate change, and recovery of top predators may often complicate both management decisions and interpretation of water-level impacts on wildlife

Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunity

Thyroid peroxidase (TPO) is the key enzyme in thyroid hormone production and a universal autoantigen in Graves’ and other autoimmune thyroid diseases. We wished to explore the expression of TPO and whether it was affected by thionamide antithyroid drugs. We studied recombinant TPO, stably expressed by a Chinese hamster ovary cell line (CHO-TPO) and transiently expressed TPO-enhanced green fluorescent protein (eGFP) and -FLAG fusion proteins. Immunoblotting of CHO-TPO cell extracts showed high-molecular weight (HMW) TPO isoforms that were resistant to reduction, as well as 110 kDa monomeric TPO. Co-immunoprecipitation and enzyme-linked-immunosorbent assay (ELISA) binding studies of FLAG- and eGFP-tagged TPO demonstrated TPO dimerisation. CHO-TPO cells cultured in methimazole (MMI) for 10 days showed a significant reduction in HMW-TPO isoforms at MMI concentrations of 1 µM and above (p < 0.01), whereas monomeric TPO expression was unchanged. We observed a similar reduction in HMW-TPO in CHO-TPO cells cultured in propylthiouracil (10 µM and above). Binding of Graves’ disease patient sera and TPO-Fabs to enzymatically active TPO that was captured onto solid phase was not abrogated by MMI. The cellular localisation of TPO in CHO-TPO cells was unchanged by MMI treatment. Our demonstration of homodimeric TPO and the reduction in HMW-TPO isoforms during thionamide treatment of CHO-TPO cells shows, for the first time, an effect of thionamides on TPO structure. This suggests a structural correlate to the effect of thionamides on TPO enzymatic activity and opens up a novel potential mechanism for thionamide immunomodulation of autoimmune thyroid disease

Gaining from Improved Dairy Cow Nutrition: Economic, environmental and animal health benefits

A majority of UK dairy herds have the potential to increase profitability by improving the ration of their cows. This paper reports that gains averaging around £100 per cow have been made within one year of adopting the Keenan Hi-Fibre ration by 239 UK herds in 2006 and 2007. Larger gains have been made by herds in France. The key performance indicator underlying these gains is Feed Conversion Efficiency, whereby the same, or even a smaller amount of Dry Matter Intake generates higher yields per cow. Importantly, the gains are associated with large improvements in animal health and reductions in greenhouse gases per litre of milk produced

Efficiency innovation and dairy production: a multi-market case study

The poultry and pig industries have for many years had a focus on feed efficiency (more meat per unit of feed), but the dairy industry has not paid sufficient attention to this. For the past decade Joseph Keenan and Sons has been researching and innovating to raise feed efficiency in dairying and beef production in concert with the sale of its feed mixer wagons. From 2006 onwards it has collected basic production records on the impact of its system on over 64,000 herds and nearly 1 million cows in 26 countries. This paper presents a number of separate approaches to analyse the effect of the system in the first 12-months in Australia/New Zealand, France, Ireland, Northern Europe and the UK. Over 70% of producers coming onto the system make positive margin gains, and the analysis is aimed at characterising the type and scale of response as well as to disentangling the reasons for success and failure. Two forms of graphic analysis have been developed based on a typology of response. Stochastic dominance analysis examines the overall effectiveness of the system and multinomial logit analysis is used to explain response in terms of conditioning factors