Electromagnetic interferences from plasmas generated in meteoroids impacts

It is shown that the plasma, generated during an impact of a meteoroid with an artificial satellite, can produce electromagnetic radiation below the microwave frequency range. This interference is shown to exceed local noise sources and might disturb regular satellite operations.Comment: 6 pages, no figures. This version macthes the published versio

Extension of nano-confined DNA: quantitative comparison between experiment and theory

The extension of DNA confined to nanochannels has been studied intensively and in detail. Yet quantitative comparisons between experiments and model calculations are difficult because most theoretical predictions involve undetermined prefactors, and because the model parameters (contour length, Kuhn length, effective width) are difficult to compute reliably, leading to substantial uncertainties. Here we use a recent asymptotically exact theory for the DNA extension in the "extended de Gennes regime" that allows us to compare experimental results with theory. For this purpose we performed new experiments, measuring the mean DNA extension and its standard deviation while varying the channel geometry, dye intercalation ratio, and ionic buffer strength. The experimental results agree very well with theory at high ionic strengths, indicating that the model parameters are reliable. At low ionic strengths the agreement is less good. We discuss possible reasons. Our approach allows, in principle, to measure the Kuhn length and effective width of a single DNA molecule and more generally of semiflexible polymers in solution.Comment: Revised version, 6 pages, 2 figures, 1 table, supplementary materia

On the properties of fractal cloud complexes

We study the physical properties derived from interstellar cloud complexes having a fractal structure. We first generate fractal clouds with a given fractal dimension and associate each clump with a maximum in the resulting density field. Then, we discuss the effect that different criteria for clump selection has on the derived global properties. We calculate the masses, sizes and average densities of the clumps as a function of the fractal dimension (D_f) and the fraction of the total mass in the form of clumps (epsilon). In general, clump mass does not fulfill a simple power law with size of the type M_cl ~ (R_cl)**(gamma), instead the power changes, from gamma ~ 3 at small sizes to gamma<3 at larger sizes. The number of clumps per logarithmic mass interval can be fitted to a power law N_cl ~ (M_cl)**(-alpha_M) in the range of relatively large masses, and the corresponding size distribution is N_cl ~ (R_cl)**(-alpha_R) at large sizes. When all the mass is forming clumps (epsilon=1) we obtain that as D_f increases from 2 to 3 alpha_M increases from ~0.3 to ~0.6 and alpha_R increases from ~1.0 to ~2.1. Comparison with observations suggests that D_f ~ 2.6 is roughly consistent with the average properties of the ISM. On the other hand, as the fraction of mass in clumps decreases (epsilon<1) alpha_M increases and alpha_R decreases. When only ~10% of the complex mass is in the form of dense clumps we obtain alpha_M ~ 1.2 for D_f=2.6 (not very different from the Salpeter value 1.35), suggesting this a likely link between the stellar initial mass function and the internal structure of molecular cloud complexes.Comment: 32 pages, 13 figures, 1 table. Accepted for publication in Ap

Assessment and treatment of distorted schemas in sexual offenders

The aim of this review is to examine the literature related to the assessment and treatment of sex offenders’ distorted schemas. Where appropriate, the review draws upon current insights from the field of social cognition to aid in the critical evaluation of the findings. First, the review considers the various different methodologies for assessing distorted schemas, discussing their strengths and limitations. Second, the review examines the work related to the treatment of sex offenders’ schemas. Suggestions for future research, and the implications for clinical practice, are highlighted in the article

Legionella pneumophila multiplication is enhanced by chronic AMPK signalling in mitochondrially diseased dictyostelium cells

Human patients with mitochondrial diseases are more susceptible to bacterial infections, particularly of the respiratory tract. To investigate the susceptibility of mitochondrially diseased cells to an intracellular bacterial respiratory pathogen, we exploited the advantages of Dictyostelium discoideum as an established model for mitochondrial disease and for Legionella pneumophila pathogenesis. Legionella infection of macrophages involves recruitment of mitochondria to the Legionella-containing phagosome. We confirm here that this also occurs in Dictyostelium and investigate the effect of mitochondrial dysfunction on host cell susceptibility to Legionella. In mitochondrially diseased Dictyostelium strains, the pathogen was taken up at normal rates, but it grew faster and reached counts that were twofold higher than in the wild-type host. We reported previously that other mitochondrial disease phenotypes for Dictyostelium are the result of the activity of an energy-sensing cellular alarm protein, AMP-activated protein kinase (AMPK). Here, we show that the increased ability of mitochondrially diseased cells to support Legionella proliferation is suppressed by antisense-inhibiting expression of the catalytic AMPK&alpha; subunit. Conversely, mitochondrial dysfunction is phenocopied, and intracellular Legionella growth is enhanced, by overexpressing an active form of AMPK&alpha; in otherwise normal cells. These results indicate that AMPK signalling in response to mitochondrial dysfunction enhances Legionella proliferation in host cells.<br /

Modeling a high mass turn down in the stellar initial mass function

Statistical sampling from the stellar initial mass function (IMF) for all star-forming regions in the Galaxy would lead to the prediction of ~1000 Msun stars unless there is a rapid turn-down in the IMF beyond several hundred solar masses. Such a turndown is not necessary for dense clusters because the number of stars sampled is always too small. Here we explore several mechanisms for an upper mass cutoff, including an exponential decline of the star formation probability after a turbulent crossing time. The results are in good agreement with the observed IMF over the entire stellar mass range, and they give a gradual turn down compared to the Salpeter function above ~100 Msun for normal thermal Jeans mass, M_J. The upper mass turn down should scale with M_J in different environments. A problem with the models is that they cannot give both the observed power-law IMF out to the high-mass sampling limit in dense clusters, as well as the observed lack of supermassive stars in whole galaxy disks. Either there is a sharper upper-mass cutoff in the IMF, perhaps from self-limitation, or the IMF is different for dense clusters than for the majority of star formation that occurs at lower density. Dense clusters seem to have an overabundance of massive stars relative to the average IMF in a galaxy.Comment: 19 pages, 2 figures, Astrophysical Journal, Vol 539, August 10, 200

Developmental contexts and features of elite academy football players: Coach and player perspectives

Player profiling can reap many benefits; through reflective coach-athlete dialogue that produces a profile the athlete has a raised awareness of their own development, while the coach has an opportunity to understand the athlete's viewpoint. In this study, we explored how coaches and players perceived the development features of an elite academy footballer and the contexts in which these features are revealed, in order to develop a player profile to be used for mentoring players. Using a Delphi polling technique, coaches and players experienced a number of 'rounds' of expressing their opinions regarding player development contexts and features, ultimately reduced into a consensus. Players and coaches had differing priorities on the key contexts of player development. These contexts, when they reflect the consensus between players and coaches were heavily dominated by ability within the game and training. Personal, social, school, and lifestyle contexts featured less prominently. Although 'discipline' was frequently mentioned as an important player development feature, coaches and players disagreed on the importance of 'training'

Recent Duplication and Functional Divergence in Parasitic Nematode Levamisole-Sensitive Acetylcholine Receptors

Helminth parasites rely on fast-synaptic transmission in their neuromusculature to experience the outside world and respond to it. Acetylcholine plays a pivotal role in this and its receptors are targeted by a wide variety of both natural and synthetic compounds used in human health and for the control of parasitic disease. The model, Caenorhabditis elegans is characterized by a large number of acetylcholine receptor subunit genes, a feature shared across the nematodes. This dynamic family is characterized by both gene duplication and loss between species. The pentameric levamisole-sensitive acetylcholine receptor has been characterized from C. elegans, comprised of five different subunits. More recently, cognate receptors have been reconstituted from multiple parasitic nematodes that are found to vary in subunit composition. In order to understand the implications of receptor composition change and the origins of potentially novel drug targets, we investigated a specific example of subunit duplication based on analysis of genome data for 25 species from the 50 helminth genome initiative. We found multiple independent duplications of the unc-29, acetylcholine receptor subunit, where codon substitution rate analysis identified positive, directional selection acting on amino acid positions associated with subunit assembly. Characterization of four gene copies from a model parasitic nematode, Haemonchus contortus, demonstrated that each copy has acquired unique functional characteristics based on phenotype rescue of transgenic C. elegans and electrophysiology of receptors reconstituted in Xenopus oocytes. We found evidence that a specific incompatibility has evolved for two subunits co-expressed in muscle. We demonstrated that functional divergence of acetylcholine receptors, driven by directional selection, can occur more rapidly than previously thought and may be mediated by alteration of receptor assembly. This phenomenon is common among the clade V parasitic nematodes and this work provides a foundation for understanding the broader context of changing anthelmintic drug targets across the parasitic nematodes

Confidentiality and public protection: ethical dilemmas in qualitative research with adult male sex offenders

This paper considers the ethical tensions present when engaging in in-depth interviews with convicted sex offenders. Many of the issues described below are similar to those found in other sensitive areas of research. However, confidentiality and public protection are matters that require detailed consideration when the desire to know more about men who have committed serious and harmful offences is set against the possibility of a researcher not disclosing previously unknown sensitive information that relates to the risk of someone being harmed.</p