Diagnóstico financiero de la empresa the walt disney

El presente trabajo de investigación consiste en realizar un análisis financiero a la compañía Walt Disney a través de la revelación de la información financiera de los años 2019,2020 y 2021 con el propósito de identificar las principales variaciones de la compañía. El problema de investigación es interpretar cuál es la situación financiera en cuanta liquidez, endeudamiento, rentabilidad y la destinación de los recursos por lo que su estudio es principalmente cuantitativo obteniendo información de distintas fuentes como documentos internos, tesis y otra información de alcance cualitativo con el fin desarrollar un diagnostico global, teniendo como base los elementos para identificar algunas variables claves para su comprensión. Finalmente se proponen las recomendaciones pertinentes en aras de obtener mejores beneficios.The present research work consists of carrying out a financial analysis of the Walt Disney Company through the disclosure of financial information for the years 2019, 2020 and 2021 with the purpose of identifying the main variations of the company. The research problem is to interpret what the financial situation is in terms of liquidity, indebtedness, profitability and the allocation of resources, so its study is mainly quantitative, obtaining information from different sources such as internal documents, these and other qualitative information with the in order to develop a global diagnosis, based on the elements to identify some key variables for its understanding. Finally, the pertinent recommendations are proposed in order to obtain better benefits

Nonpsychoactive cannabinoids in cancer : in vivo studies

RESUMEN: El cannabis alberga gran cantidad de compuestos con características de importancia en diversos procesos que incluyen los industriales, recreativos y medicinales. Los compuestos más abundantes en estas plantas son los cannabinoides, siendo los más importantes y estudiados el tetrahidrocannabinol (THC), un compuesto que a pesar de que se le han descrito múltiples propiedades medicinales y potencial terapéutico, su uso se ha visto limitado debido a sus efectos psicoactivos; y el cannabidiol (CBD) que se diferencia del anterior porque no presenta esta propiedad. Este último ha cobrado importancia por sus propiedades para tratar algunas enfermedades como el cáncer gracias a su efecto pro-apotótico, anti-proliferativo y anti-angiogénico. Esta revisión tiene como objetivo describir los mecanismos inmunomoduladores asociados a los cannabinoides no psicoactivos en modelos in vivo de diferentes tipos de cáncer como: glioblastoma, cáncer de seno, cáncer de pulmón, cáncer colorrectal y melanoma. Entre los hallazgos obtenidos en diferentes trabajos se destaca la capacidad de este compuesto, en combinación con otros fármacos antineoplásicos, de inducir apoptosis e inhibir la metástasis mediante la regulación de ciertas moléculas como CD31, Id-1, caspasas 3 y 9, y metaloproteinasas, entre otras. A pesar de que estos compuestos son vistos como prometedores fármacos, hacen falta más estudios que evalúen los mecanismos inmunomoduladores de los cannabinoides no psicoactivos, debido a que evidencias previas solo han descrito sus propiedades in vitro, por lo tanto, hace falta ahondar un poco más en el estudio de modelos in vivo, para un posible uso posterior en ensayos clínicos, y de esta forma ser considerados como verdaderos agentes terapéuticos.ABSTRACT: Cannabis harbors many compounds with important characteristics in various processes, including industrial, recreational, and medicinal. The most abundant compounds in these plants are cannabinoids. Tetrahydrocannabinol (THC) is the most important and most studied of these, but despite its multiple medicinal properties and the therapeutic potential described so far, it has been seen as of limited use due to its being characterized as psychoactive. Cannabidiol (CBD), however, does not present psychoactive properties. The latter has gained importance as its properties may treat some diseases, including cancer, due to its pro-apototic, antiproliferative, and anti-angiogenic effects. This review aims to describe the immunomodulatory mechanisms associated with non-psychoactive cannabinoids in in vivo models of different types of cancer such as glioblastoma, breast, lung and colorectal cancer, and melanoma. Among the findings obtained in different studies is the ability of this compound, in combination with other antineoplastic drugs, to induce apoptosis and inhibit metastasis through the regulation of CD31, Id-1, caspases 3 and 9, and metalloproteinases, among others molecules. Although these compounds are seen as promising drugs, more studies are needed to evaluate the immunomodulatory mechanisms of nonpsychoactive cannabinoids, since previous evidence has only described their in vitro properties; therefore, it is necessary to delve more into in vivo model studies and evaluate their possible uses in clinical trials. In this way, they can be considered as true therapeutic agents

Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis

Seven styrylquinolines were synthesized in this study. Two of these styrylquinolines are new and were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, and normal cells (HaCaT). According to the results, compounds 3a and 3d showed antiproliferative activity in SW480 and SW620 cells, but their effect seemed to be caused by different mechanisms of action. Compound 3a induced apoptosis independent of ROS production, as evidenced by increased levels of caspase 3, and had an immunomodulatory effect, positively regulating the production of different immunological markers in malignant cell lines. In contrast, compound 3d generated a pro-oxidant response and inhibited the growth of cancer cells, probably by another type of cell death other than apoptosis. Molecular docking studies indicated that the most active compound, 3a, could efficiently bind to the proapoptotic human caspases-3 protein, a result that could provide valuable information on the biochemical mechanism for the in vitro cytotoxic response of this compound in SW620 colon carcinoma cell lines. The obtained results suggest that these compounds have chemopreventive potential against CRC, but more studies should be carried out to elucidate the molecular mechanisms of action of each of them in depth

Evaluation of the Effects of Genistein In Vitro as a Chemopreventive Agent for Colorectal Cancer—Strategy to Improve Its Efficiency When Administered Orally

Colorectal Cancer (CRC) ranks third in terms of incidence and second in terms of mortality and prevalence worldwide. In relation to chemotherapy treatment, the most used drug is 5-fluorouracil (5-FU); however, the use of this drug generates various toxic effects at the systemic level. For this reason, new therapeutic strategies are currently being sought that can be used as neoadjuvant or adjuvant treatments. Recent research has shown that natural compounds, such as genistein, have chemotherapeutic and anticancer effects, but the mechanisms of action of genistein and its molecular targets in human colon cells have not been fully elucidated. The results reported in relation to non-malignant cell lines are also unclear, which does not allow evidence of the selectivity that this compound may have. Therefore, in this work, genistein was evaluated in vitro in both cancer cell lines SW480 and SW620 and in the non-malignant cell line HaCaT. The results obtained show that genistein has selectivity for the SW480 and SW620 cell lines. In addition, it inhibits cell viability and has an antiproliferative effect in a dose-dependent manner. Increased production of reactive oxygen species (ROS) was also found, suggesting an association with the cell death process through various mechanisms. Finally, the encapsulation strategy that was proposed made it possible to demonstrate that bacterial nanocellulose (BNC) is capable of protecting genistein from the acidic conditions of gastric fluid and also allows the release of the compound in the colonic fluid. This would allow genistein to act locally in the mucosa of the colon where the first stages of CRC occur