Art Therapy and Neuroscience: A Model for Wellness

This research aimed to illuminate the connections between art therapy and neuroscience by using qualitative research methods. Two art therapists and a psychologist with neuroscience backgrounds were interviewed. Analyzing artwork made by the researcher and results of the interviews allowed for themes to emerge: connection, perspective, desire for understanding and being trapped in time. The researcher’s further inquiry into these emergent themes allowed for the idea of the creative spirit to present itself as a basic human need which has existed since the beginning of time. Using this newfound perspective the researcher has embraced the importance of creating an art therapy model that focuses on a holistic approach to life-long wellness which uses creative expression as a means for understanding, connection, and healing

Models for optimizing the mix of air launched missiles for repair processing

The research for this thesis is concerned with the logistics of air-to-air and air-to-ground missiles. Specific emphasis is placed on the development of models to determine the optimal mix of air launched missiles (ALMs) to induct for repair each quarter at intermediate level maintenance facilities. The Navy operates three such repair facilities. A set of three models are described which are intended to assist in managing the missile repair process. These models allow for effective control of missile readiness objectives, maintenance budgets, and repair priorities. This thesis proposes three linear programming models for the Naval Air Systems Command to use in planning the repair of air-launched missiles through the Naval Weapons Stationshttp://archive.org/details/modelsforoptimiz00taylLieutenant Commander, United States NavyPacific Missile Test Center, Point Mugu, CaliforniaApproved for public release; distribution is unlimited

Building the Research Enterprise in the Academic Environment:

The preponderance of nursing research conducted in the United States occurs in schools of nursing. Accordingly, a major role for academic leaders in nursing education is the development of a resource base to support and expand the research mission of the nursing program. The intersection of research and practice is also an essential element for assuring the relevance of nursing research and advancing the application of the evidence generated by nursing scientists. The following paper presents an introduction to nursing research in the U.S. with an emphasis on the educational and operational resources needed to maintain a robust research enterprise in schools of nursing. Key supports for this important work are profiled, including federal agencies and programs committed to advancing nursing science and the more widespread engagement of nurses in team-based research. The paper concludes with a look at efforts underway to enhance quality in research-focused doctoral programs and an assessment of critical roles nursing deans and faculty play in championing nursing research and preparing the next generation of nurse scientists. _________________ La majeure partie des activités de recherche en sciences infirmières aux États-Unis est effectuée dans les écoles de sciences infirmières. Par conséquent, les leaders académiques en sciences infirmières doivent jouer un rôle majeur dans l’établissement d’un ensemble de ressources pour appuyer et élargir la mission de recherche liée aux programmes de sciences infirmières. De plus, le lien entre la recherche et la pratique est un élément essentiel pour assurer la pertinence de la recherche effectuée en sciences infirmières et pour soutenir la mise en application des résultats probants produits par les scientifiques infirmières. L’article qui suit présente le développement de la recherche en sciences infirmières aux États-Unis, tout en mettant l’accent sur les ressources éducatives et opérationnelles nécessaires au maintien d’une importante activité de recherche dans les écoles de sciences infirmières. Les principaux appuis à cet important travail sont présentés, en particulier celui des organismes et programmes fédéraux mobilisés pour faire avancer les sciences infirmières et l’engagement grandissant des infirmières pour diriger des travaux de recherche en équipe. En guise de conclusion, l’article porte un regard sur les efforts en cours visant à accroître la qualité des programmes de doctorat axés sur la recherche. Il examine les rôles cruciaux que jouent les doyens/doyennes et les professeures de sciences infirmières pour promouvoir la recherche en sciences infirmières et préparer la prochaine génération d’infirmières/d’infirmiers scientifiques

A P53-TLR3 Axis Ameliorates Pulmonary Hypertension by Inducing BMPR2 Via IRF3

Pulmonary arterial hypertension (PAH) features pathogenic and abnormal endothelial cells (ECs), and one potential origin is clonal selection. We studied the role of p53 and toll-like receptor 3 (TLR3) in clonal expansion and pulmonary hypertension (PH) via regulation of bone morphogenetic protein (BMPR2) signaling. ECs of PAH patients had reduced p53 expression. EC-specific p53 knockout exaggerated PH, and clonal expansion reduced p53 and TLR3 expression in rat lung CD117+ ECs. Reduced p53 degradation (Nutlin 3a) abolished clonal EC expansion, induced TLR3 and BMPR2, and ameliorated PH. Polyinosinic/polycytidylic acid [Poly(I:C)] increased BMPR2 signaling in ECs via enhanced binding of interferon regulatory factor-3 (IRF3) to the BMPR2 promoter and reduced PH in p53−/− mice but not in mice with impaired TLR3 downstream signaling. Our data show that a p53/TLR3/IRF3 axis regulates BMPR2 expression and signaling in ECs. This link can be exploited for therapy of PH

A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3

Pulmonary arterial hypertension (PAH) features pathogenic and abnormal endothelial cells (ECs), and one potential origin is clonal selection. We studied the role of p53 and toll-like receptor 3 (TLR3) in clonal expansion and pulmonary hypertension (PH) via regulation of bone morphogenetic protein (BMPR2) signaling. ECs of PAH patients had reduced p53 expression. EC-specific p53 knockout exaggerated PH, and clonal expansion reduced p53 and TLR3 expression in rat lung CD117+ ECs. Reduced p53 degradation (Nutlin 3a) abolished clonal EC expansion, induced TLR3 and BMPR2, and ameliorated PH. Polyinosinic/polycytidylic acid [Poly(I:C)] increased BMPR2 signaling in ECs via enhanced binding of interferon regulatory factor-3 (IRF3) to the BMPR2 promoter and reduced PH in p53−/− mice but not in mice with impaired TLR3 downstream signaling. Our data show that a p53/TLR3/IRF3 axis regulates BMPR2 expression and signaling in ECs. This link can be exploited for therapy of PH