Targeted Drug Delivery System for Kidney and/or Liver Failure Patients Using Human Serum Albumin

Compromised liver and/or kidney function reduces the acceptable dosage of a variety of medications that can be administered to patients. These patients still have a need for drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs), antivirals, and antibiotics. The project goal is to provide a drug delivery system to accommodate these reduced dosage limits with added therapeutic benefits to address symptoms of liver or kidney failure. Localized drug delivery allows for a smaller, concentrated dose rather than inundating the patient\u27s system with the drug of interest. Human serum albumin (HSA) is a researched candidate for drug delivery with therapeutic properties. HSA was tested as a drug delivery vehicle for localized, percutaneous drug release aided by a displacing compound and changes in temperature and ultrasound generated by an external device. Dynamic light scattering (DLS), UV/Vis spectroscopy, and optical microscopy were employed in verifying drug binding, release, and effectiveness. The optimization of the proposed drug release method, the design of the device to promote drug delivery, and the testing of the drug delivery system with in vitro tissue testing were performed to validate the designed system

Review of visceroptosis and allied abdominal conditions associated with chronic invalidism

The condition in which an absence of well -being and a lack of energy accompanies persistent abdominal symptoms of no known pathology, is one worthy of investigation. Never leading to a fatal termination it nevertheless assumes considerable importance from the mass of suffering and the loss of economic efficiency it produces.Not that it has failed to receive consideration in the past ; on the contrary, a vast literature has accumulated around this one condition. The magnitude of this literature is not obvious at first sight, and only becomes so when it is realised that conditions as diverse as nervous dyspepsia, nephroptosis, gastroptosis, visceroptosis, autointoxication, intestinal stasis, chronic a.p?oendicitis caecum mobile, and others too numerous to mention, merely re,?resent different interpretations of a single symptom complex. This view is forced upon one by an unprejudiced study of the clinical material as it presents itself in general practice, and the conclusion seems inevitable that some common whole must underlie these diverse manifestations.In the past many investigators have come to the same conclusion. This they reached by an intensive and specialised study of one side of the problem, and for that reason, presumably, failed to obtain the general assent the facts deserved. G It has, therefore, seemed to me worth while to approach the problem from the wide angle of general practice. The latter offers a very special facility for the study of the condition, in that the genesis, progress and termination can be followed by one observer in a way not possible in any other branch of medicine

Beating Down the Fear: The Civil Sphere and Political Change in South Carolina, 1940-1962

This dissertation contends that print culture – newspapers in particular – played a decisive role in launching the black civil rights movement and shaping the white response to it during the middle of the twentieth century. Focusing on South Carolina, this study is the first to use civil sphere theory and frame analysis to explore the role of cultural expression in the political struggle over black equality in the years immediately before and after World War II. It shows how African-American editors and other activists made strategic use of the society’s symbolic codes concerning justice, freedom, and liberty to elicit empathy from potential allies and break down opposition to political and social acceptance. At the same time, this dissertation examines how some whites employed an equally powerful “discourse of repression” to limit the black movement’s gains and help launch the modern conservative movement. By placing cultural symbolism and interpretive communication at the heart of civic life, this study reveals the inextricable link between mass media, public opinion, and formal political power. In doing so, it raises new questions about the received historical narrative of a fully emerged professionalized, independent, and nonpartisan daily press in the United States by the second half of the twentieth century. This dissertation reveals a deep connection between South Carolina’s white press and partisan politics in the state well into the 1970s. Yet it also shows how partisan journalists had begun to hide their activism from the public to maintain their status as independent sources of information and interpretation

Designing Meetings Systemically: Towards a deeper, more holistic understanding of how meetings work

Meetings consume significant organisation resources and are important for organisational success but attendees tend to consider them poor value for time. Many studies of meetings have focused on identifying correlational links between individual variables and meeting satisfaction. Few have studied meetings holistically leading to a lack of understanding on which to base systemic design of meetings. This research considers meetings as embedded in wider systems and studies them as a systems challenge. Eighteen knowledge workers were interviewed using a range of techniques to explore a meeting’s wider context and then a systems approach was used to analyse this context. The findings confirm that meetings are influenced by many factors from other systems including the organisation, the team, the work and the individuals. A rich picture identifies four non-clock stages of a meeting embedded in its wider context, including one stage not previously identified in the literature where attendees transition from their individual pre-meeting tasks to form a cohesive unit for the duration of the meeting. The rich picture identifies eight activities which underpin a holistic understanding of meetings, across the four stages, including Social Contracting which three studies’ findings show is important but under-represented in extant literature. A conceptual framework was developed from the findings and trialled with ten meeting hosts who confirmed that it helped them design meetings more systemically. The conceptual framework provides a holistic picture of meetings which encourages and informs systemic meeting design. It also provides a deeper explanation for many of the individual design features that have been linked to meeting satisfaction and unifies meeting science literature with a common language and set of shared reference points. It emphasises the value of systemic meeting design, treating meeting design as a systems challenge – from which many of the future meetings we all attend will benefit

Reflective Practice For Leadership (RPL)

The Reflective Practice for leadership described in this project leans towards a wellcrafted exercise, a struchn·ed and collaborative approach to solving professional dilemmas. Reflective Practice can occur individually, with a partner, or within a group. In this project, reflective practice is a collective inquiry and exploration of the knowledge, skills and behaviors that support leadership development within the context of a group, individuals critically examine why certain situations result in stress, confusion, or concern and what strategies exist to bring resolution or clarity to the presenting issue. Moreover, the two major goals for RPL are: (I) to create a forum for exploring leadership capacity; and (2) to identify topics for a leadership development program. The forum, or reflective practice group, represents a grass roots effort to flush out those issues with which GBCC employees struggle. These issues will subsequently provide substance for a leadership program on a more global scale

Project Manager Personality as a Factor for Success

Much has been written regarding project success, and one of the factors contributing to project success is the role of the project manager. Furthermore, project success can be enhanced by selecting the best project manager, and by assigning project managers whose attributes best align with project type. We investigated the role of the project manager\u27s personality on project success using the Big Five personality model. We surveyed United States Department of Defense project managers to determine specific Big Five personality traits which were more likely to positively predict project manager success. The findings indicate conscientiousness and openness to experience were both good predictors of successful project managers. The results may be useful as one consideration when hiring project managers, and when selecting project managers to best match certain project types

DEVELOPMENT OF INSTRUCTIONAL VIDEOTAPE FOR QUALITATIVE ANALYSIS

One of the major concerns of the coach and Physical Education teacher is to effectively analyze movement. Sport performance is characterized by diverse movement patterns performed at high speeds. Under these circumstances the observer must priorize movement components, detect errors and make decisions regarding the efficiency of movement. Ultimately the criteria for competance in movement analysis is the ability of the coach or teacher to administer appropriate feedback (Armstrong, 1984)

BALL SIZE AND PERFORMANCE

Basketball is one sport where equipment design research has been almost nonexistent. With the exception of a height-adjustable basket and a junior-sized ball for elementary players, the size and weight of the first official basketball has remained the same for college men and women since its initial production in 1941 (Pitts, 1985). It has been suggested that skill Performance by women may be limited in those sports which do not have modified equipment designed specifically for their use (Eason, 1962; Pitts, 1985). The literature attributes differences in height, weight, hand size, and upper body strength between males and females to be responsible for a "handicapped" performance by women (as compared to men) when using equipment originally designed for men (Easson 1978, Husak 1984, Daily & ijarris 1984, Critelli 1984, and pitts 1985)

Audit report criteria: An empirical examination; Technical Research Report 3;

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