High-resolution cryogenic capacitance measurements of FD-SOI structures using a capacitance bridge

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Dispersive vs charge-sensing readout for linear quantum registers

International audienceWe present recent progress in the implementation of scalable schemes for spin qubit readout in one dimensional quantum registers based on fully-depleted silicon-on-insulator (FDSOI) technology. We compare two schemes both based on rf gate reflectometry. The first one, denoted as dispersive readout, minimizes the device overhead thereby facilitating scale-up to large qubit registers. The second one, denoted as charge-sensing readout, requires additional readout components but is less sensitive to the strength of the interdot coupling facilitating operation in the few-electron regime. We demonstrate single-shot charge sensing with a fidelity of 97% in 5 μs. Finally, we propose a scalable device architecture for linear qubit registers relying on charge-sensing readout

A novel homozygous splice acceptor site mutation of KISS1R in two siblings with normosmic isolated hypogonadotropic hypogonadism

Context: Loss-of-function mutations of the kisspeptin-1 receptor gene, KISS1R, have been identified in patients with normosmic isolated hypogonadotropic hypogonadism (nIHH). Objective: To investigate KISS1R defects in patients with absent or delayed puberty. Patients: We investigated KISS1R gene defects in a cohort of 99 Brazilian patients with nIHH or constitutional delay of puberty (CDP). Methods: The entire coding region of KISS1R was amplified by PCR followed by automatic sequencing. In addition, screening for KISS1R exonic deletions was performed by multiplex ligation-dependent probe amplification. Results: One novel homozygous KISS1R mutation was identified in two siblings with nIHH. This variant was an insertion/deletion (indel) mutation characterized by the deletion of three nucleotides (GCA) at position -2 to -4, and by the insertion of seven nucleotides (ACCGGCT) at the same position, within the 30 splice acceptor site of intron 2 of KISS1R. The brothers who carried this KISS1R mutation had no clinical evidence of pubertal development at the ages of 14 and 20 years. Computational analysis of this indel mutation predicted the generation of an abnormal protein. In addition, a new heterozygous KISS1R variant (p.E252Q) was identified in a male patient with sporadic nIHH. However, in vitro studies of this variant did not demonstrate functional impairment. Only known polymorphisms were identified in patients with CDP. Conclusion: Loss-of-function mutations of KISS1R represents a rare cause of nIHH, and was absent in patients with CDP. We have described a novel KISS1R homozygous splice acceptor site mutation in the familial form of nIHH.Fundacao de Amparo Estado de Sao Paulo - FAPESP[05/04726-]Fundacao de Amparo Estado de Sao Paulo - FAPESP[0550146-5]Eunice Kennedy Shriver NICHD/NI

Material and integration challenges for large scale Si quantum computing

International audienceSi spin qubits are very promising to enable large scale quantum computing as they are fast, of high quality and small. However, they are still lagging behind in terms of number of qubits. Indeed there are material and integration challenges to be tackled before fully expressing their potential

Challenges and perspectives in the modeling of spin qubits

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