Synthesis, reactions and biological evaluation of benzyltriazolophthalazine derivatives

A series of triazolophthalazine derivatives (4-22) were synthesized and characterized. The structures of the newly synthesized compounds were confirmed by spectral data. The newly synthesized compounds were also screened for their antimicrobial activity

The Dome Technique for Managing Massive Anterosuperior Medial Acetabular Bone Loss in Revision Total Hip Arthroplasty: Short-Term Outcomes

PURPOSE: The dome technique is a technique used in performance of revision total hip arthroplasty (THA) involving intraoperative joining of two porous metal acetabular augments to fill a massive anterosuperior medial acetabular bone defect. While excellent outcomes were achieved using this surgical technique in a series of three cases, short-term results have not been reported. We hypothesized that excellent short-term clinical and patient reported outcomes could be achieved with use of the dome technique. MATERIALS AND METHODS: A multicenter case series was conducted for evaluation of patients who underwent revision THA using the dome technique for management of Paprosky 3B anterosuperior medial acetabular bone loss from 2013-2019 with a minimum clinical follow-up period of two years. Twelve cases in 12 patients were identified. Baseline demographics, intraoperative variables, surgical outcomes, and patient reported outcomes were acquired. RESULTS: The implant survivorship was 91% with component failure requiring re-revision in only one patient at a mean follow-up period of 36.2 months (range, 24-72 months). Three patients (25.0%) experienced complications, including re-revision for component failure, inter-prosthetic dual-mobility dissociation, and periprosthetic joint infection. Of seven patients who completed the HOOS, JR (hip disability and osteoarthritis outcome score, joint replacement) survey, five patients showed improvement. CONCLUSION: Excellent outcomes can be achieved using the dome technique for management of massive anterosuperior medial acetabular defects in revision THA with survivorship of 91% at a mean follow-up period of three years. Conduct of future studies will be required in order to evaluate mid- to long-term outcomes for this technique

Pilot Study Examining Feasibility and Comparing the Effectiveness of Decision Aids for Hip and Knee Osteoarthritis: A Randomized Trial

Background. There are many patient decision aids (DAs) available, yet there is limited evidence on comparative effectiveness of different tools. Objective. To examine feasibility of a study protocol and gather preliminary data on comparative effectiveness. Methods. Adult patients seeing a surgeon to discuss treatment for hip or knee osteoarthritis were randomized to hip and knee DAs from two vendors. Pre-visit survey included Hip/Knee Decision Quality Instrument, DA usage, health literacy, and quality of life (EQ-5D). Surgical status was ascertained 6 months post-visit. We examined response rates, eligibility, and compared the two DAs on amount of use, knowledge scores, and receipt of preferred treatment. Results. Overall response rate was 58/74 (78%) and did not differ by study arm. More patients in DA-A group reported reviewing all the DAs (64.5% DA-A v. 24.0% DA-B, P = 0.003). Knowledge scores were similar across arms (55.2% DA-A v. 48.8% DA-B, P = 0.4). For DA-B, knowledge scores were higher for those who reviewed all the DAs compared with those who did not (80% knowledge v. 39% knowledge, respectively, P = 0.004), while scores for DA-A did not vary by usage (62% knowledge v. 53% knowledge, respectively, P = 0.3). A similar percentage of each group received their preferred treatment (77% v. 73%, P = 0.8). Patients who were unsure about preferred treatment at baseline were more likely to have surgery in the DA-A arm compared with the DA-B arm (55% v. 20%, P = 0.1). Limitations. Small sample; patients were only surveyed pre-visit. Conclusion. Despite having different content and formats, the two DAs had similar overall effectiveness. Patients were more likely to review all of DA-A; however, patients who reviewed all of DA-B had the highest knowledge scores

Promoting fractional frequency reuse performance for combating pilot contamination in massive multiple input multiple output

Massive multiple-input multiple-output (MIMO) improves spectrum efficiency by increasing the capacity of the wireless structure. Therefore, massive MIMO is promising for fifth generation (5G) wireless communications. In massive MIMO, channel estimation is a crucial part that should achieve reliable performance. Pilots are sent from the end-users to be used for estimating the channel. However, the problem of interference in pilot contamination affects the performance for cell-edge users. Specifically, pilot contamination appears when the same pilot sequence is utilized at the same time by more than one terminal. This lead to an inaccurate estimation of the channel. Consequently, the decoded data will not be reliable. For mitigating these pilot contamination effects, an enhanced fractional frequency reuse (eFFR) scheme is proposed that uses an algorithm in the allocation of pilot sequences to end users’ devices based on the locations of the users from the target base station (BS). The simulation results exhibit that the proposed scenario outweighs the traditional FFR within both signal to interference, and noise ratio (SINR), and capacity. Consequently, the suggested scenario enhances the performance of more than 80% of the cell terminals and the other 20% of the terminals have a slightly lower performance compared to the FFR

Correlation between serum uric acid and pulmonary arterial hypertension based on echo probability in patients with obstructive sleep apnea syndrome

Abstract Background Obstructive sleep apnea–hypopnea syndrome is the most common form of SRBDs. Recurrent hypoxia, which accompanies OSAHS, increases the degradation of ATP, which in turn increase uric acid concentration that can be used as a biomarker of tissue hypoxia in OSAHS. There is still debate about whether OSAHS is an independent contributor to pulmonary arterial hypertension. Aim of the work This study aimed to correlate serum uric acid levels and PAH in OSAHS patients. Methods We enrolled 100 patients diagnosed with OSAHS using polysomnography. Patients were divided into three severity groups: mild OSA (5 ≤ AHI < 15), moderate OSA (15 ≤ AHI < 30), and severe (30 ≤ AHI < 60). Serum uric acid was measured the morning after polysomnography. All patients underwent standard echocardiograms, and pulmonary artery systolic pressure calculation was done. Results Among our studied patients (66% males, 34% females), the mean age was 53.04 ± 8.45 years. Six percent, 38%, and 56% were diagnosed as mild, moderate, and severe OSAHS, respectively. The mean AHI was 31.93 ± 11.78 event. Pulmonary HTN was detected in 78% of patients. Those with elevated uric acid levels represented 92.3% of patients versus 9.1% of patients without pulmonary HTN, p < 0.001. The level of serum uric acid positively correlated with pulmonary HTN level. Conclusion Pulmonary arterial pressure correlated positively with serum uric acid level. Both serum uric acid level and PAP positively correlated with the severity of OSA. Further confirmation with right heart catheterization is essential. Trial registration NCT05967754 , on July 22, 2023 — retrospectively registered

Analgesic-loaded uhmwpe can improve the efficacy of antibacterial therapy for prosthetic joint infections

Statement of Purpose: Total joint arthroplasty is often associated with two major complications: post-operative pain and periprosthetic joint infection (PJI). Previously we showed that ultra-high molecular weight polyethylene (UHMWPE) bearing surfaces can be used for local delivery of drugs(1). Given that some analgesics possess antibacterial properties(2), it is possible to use analgesiceluting UHMWPE in multimodal antibacterial therapy against PJI. Current clinical approaches to treat PJI involve local administration of various antibiotics such as gentamicin, tobramycin, and vancomycin. Here, we study the potential combinatorial effects of bupivacaine-eluting UHMWPE with gentamicin, a commonly used antibiotic to treat PJI, against Staphylococcus aureus – a pathogen very commonly associated with PJI