Коротка історія Радянської Соціалістичної Республіки Тавріди (1918 р.)

Familial Alzheimer's disease (FAD) treatment trials raise interest in the variable occurrence of cerebral amyloid angiopathy (CAA); an emerging important factor in amyloid-modifying therapy. Previous pathological studies reported particularly severe CAA with postcodon 200 PSEN1 mutations and amyloid beta coding domain APP mutations. As CAA may manifest as white matter hyperintensities (WMH) on magnetic resonance imaging, particularly posteriorly, we investigated WMH in 52 symptomatic FAD patients for associations with mutation position. WMH were visually rated in 39 PSEN1 (18 precodon 200); 13 APP mutation carriers and 25 healthy controls. Ten PSEN1 mutation carriers (5 precodon 200) had postmortem examination. Increased WMH were observed in the PSEN1 postcodon 200 group and in the single APP patient with an amyloid beta coding domain (p.Ala692Gly, Flemish) mutation. WMH burden on MRI correlated with severity of CAA and cotton wool plaques in several areas. The precodon 200 group had younger ages at onset, decreased axonal density and/or integrity, and a greater T-lymphocytic response in occipital deep white matter. Mutation site contributes to the phenotypic and pathological heterogeneity witnessed in FAD

Von der alternativen zur prekären Familienform? Der Wandel des Zusammenhangs von Bildung und nichtehelichen Familienformen in Deutschland.

This paper examines the association of education and family forms based on data of the German microcensus 1996–2012. The investigation shows that highly educated women in western Germany had a higher probability of living in a nonmarital instead of a marital union. With an increase in the share of nonmarital births, the association has reversed. Likewise, the highly educated couples were initially the vanguards of living in nonmarital unions with children, but they are nowadays the least likely to do so. Patterns differ between eastern and western Germany, though.Der Beitrag untersucht den Zusammenhang von Bildung und Familienform auf Basis des deutschen Mikrozensus 1996–2012. Es zeigt sich, dass sich in Westdeutschland eine positive Beziehung zwischen Bildungsniveau und nichtehelichem Zusammenleben mit zunehmender Verbreitung dieser Lebensform umgekehrt hat. Es wird zudem deutlich, dass im Westen Deutschlands bildungshomogene Paare am oberen Ende der Bildungsskala die Pioniere der Verbreitung nichtehelicher Lebensgemeinschaften mit Kindern waren. In Ostdeutschland zeigen sich andere Muster als in Westdeutschland