I’m hearing rumors that there is an echo chamber on campus. Are they true? Where is it located?

Abbot Pennings answers a question about echo chambers on campus, archived from the SNC website

The combinatorics of interval-vector polytopes

An \emph{interval vector} is a $(0,1)$-vector in $\mathbb{R}^n$ for which all the 1's appear consecutively, and an \emph{interval-vector polytope} is the convex hull of a set of interval vectors in $\mathbb{R}^n$. We study three particular classes of interval vector polytopes which exhibit interesting geometric-combinatorial structures; e.g., one class has volumes equal to the Catalan numbers, whereas another class has face numbers given by the Pascal 3-triangle.Comment: 10 pages, 3 figure

Common Pitfalls in Analysis of Tissue Scores

Histopathology remains an important source of descriptive biological data in biomedical research. Recent petitions for enhanced reproducibility in scientific studies have elevated the role of tissue scoring (semiquantitative and quantitative) in research studies. Effective tissue scoring requires appropriate statistical analysis to help validate the group comparisons and give the pathologist confidence in interpreting the data. Each statistical test is typically founded on underlying assumptions regarding the data. If the underlying assumptions of a statistical test do not match the data, then these tests can lead to increased risk of erroneous interpretations of the data. The choice of appropriate statistical test is influenced by the study’s experimental design and resultant data (eg, paired vs unpaired, normality, number of groups, etc). Here, we identify 3 common pitfalls in the analysis of tissue scores: shopping for significance, overuse of paired t-tests, and misguided analysis of multiple groups. Finally, we encourage pathologists to use the full breadth of resources available to them, such as using statistical software, reading key publications about statistical approaches, and identifying a statistician to serve as a collaborator on the multidisciplinary research team. These collective resources can be helpful in choosing the appropriate statistical test for tissue-scoring data to provide the most valid interpretation for the pathologist

De Agnes à Beatriz : intermidialidade entre literatura, música e cinema

Este trabalho tem como proposta identificar as relações intermidiáticas entre Literatura, Música e Cinema, a partir da análise do poema “O grande circo místico”, de Jorge de Lima, da canção de Chico Buarque/Edu Lobo e do filme de Cacá Diegues, tendo como fio condutor a personagem Beatriz. Para isso, buscou-se como embasamento teórico autores referência nos estudos sobre Intermidialidade, como Claus Clüver e Irina Rajewsky, que conceitualizam o termo “mídia” e “intermidialidade, além de proporcionarem possíveis categorias de classificação de fenômenos intermidiáticos, sendo eles transposição midiática, combinação de mídias e referência midiática.This undergraduate thesis aims to identify the intermedia relations between literature, music, and cinema, based on the analysis of the poem “O Grande Circo Místico”, by Jorge de Lima, the song by Chico Buarque/Edu Lobo, and the film by Cacá Diegues, having the character Beatriz as a guiding thread. Reference authors in studies on intermediality, such as Claus Clüver and Irina Rajewsky, were used as the thesis' theoretical basis, as they conceptualize the term “media” and “intermediality”, in addition to providing possible categories of classification of intermedial phenomena, being them medial transposition, media combination, and intermedial references

The Data Imaginary: Fears and Fantasies

The Data Imaginary: Fears and Fantasies brings together eminent and emerging artists and designers to show how creative applications of data technology are crucial for a vital, inclusive and sustainable future. The exhibition includes artworks and designs that engage audiences in critical, playful and agentic reflections on data and creative technologies. Through the exhibition, workshops, podcast and publication, the audience will be empowered to respond to climate change patterns and future city design, interact with empathy from remote locations, learn about Indigenous cultural knowledges and reflect on everyday habits that secure data privacy. Dedicated url: http://thedataimaginary.com

Metastatic Squamous Cell Carcinoma in a Northern Brown Bandicoot (<i>Isoodon macrourus</i>)

Aside from a handful of notable exceptions, neoplasia is not reported as a major cause of mortality in wild animal populations and often goes undetected. For northern brown bandicoots specifically, there are few reported tumors in the literature and on file in the Australian Registry of Wildlife Health. This report describes a case of squamous cell carcinoma in a northern brown bandicoot (Isoodon macrourus), with metastases to the draining lymph nodes and lung. This neoplasm consisted predominantly of well-differentiated squamous cells and multifocal keratin pearls, with areas possibly consistent with epithelial to mesenchymal transition, as identified by positive immunohistochemical staining by both pancytokeratin (AE1/AE3) and vimentin. Additional investigations were negative for bandicoot papillomatosis carcinomatosis viruses

The effect of antineoplastic drugs in a male spontaneous mammary tumor model

Male breast cancer is a rare disease. The limited number of clinical cases has led to the primary treatments for men being derived from female breast cancer studies. Here the transgenic strain FVB/N-Tg(MMTV-PyVT)634Mul/J (also known as PyVT) was used as a model system for measuring tumor burden and drug sensitivity of the antineoplastic drugs tamoxifen, cisplatin, and paclitaxel on tumorigenesis at an early stage of mammary carcinoma development in a male mouse model. Cisplatin treatment significantly reduced tumor volume, while paclitaxel and tamoxifen did not attenuate tumor growth. Cisplatin treatment was shown to induce apoptosis, grossly observed by reduced tumor formation, through reduced Bcl-2 and survivin protein expression levels with an increase in caspase 3 expression compared to control tumors. Tamoxifen treatment significantly altered the hormone receptor expression levels of the tumor, while additionally upregulating Bcl-2 and Cyclin D1. This suggests an importance in hormonal signaling in male breast cancer pathogenesis. The results of this study provide valuable information toward the better understanding of male breast cancer and may help guide treatment decisions

Eating As Treatment (EAT): A Stepped-Wedge, Randomized Controlled Trial of a Health Behavior Change Intervention Provided by Dietitians to Improve Nutrition in Patients With Head and Neck Cancer Undergoing Radiation Therapy (TROG 12.03)

Purpose: Malnutrition in head and neck cancer (HNC) treatment is common and associated with poorer morbidity and mortality outcomes. This trial aimed to improve nutritional status during radiation therapy (RT) using a novel method of training dietitians to deliver psychological techniques to improve nutritional behaviors in patients with HNC. Methods and Materials: This trial used a stepped-wedge, randomized controlled design to assess the efficacy of the Eating As Treatment (EAT) program. Based on motivational interviewing and cognitive behavioral therapy, EAT was designed to be delivered by oncology dietitians and integrated into their clinical practice. During control steps, dietitians provided treatment as usual, before being trained in EAT and moving into the intervention phase. The training was principles based and sought to improve behavior-change skills rather than provide specific scripts. Patients recruited to the trial (151 controls, 156 intervention) were assessed at 4 time points (the first and the final weeks of RT, and 4 and 12 weeks afterward). The primary outcome was nutritional status at the end of RT as measured by the Patient-Generated Subjective Global Assessment. Results: Patients who received the EAT intervention had significantly better scores on the primary outcome of nutritional status at the critical end-of-treatment time point (β = −1.53 [−2.93 to −.13], P =.03). Intervention patients were also significantly more likely than control patients to be assessed as well-nourished at each time point, lose a smaller percentage of weight, have fewer treatment interruptions, present lower depression scores, and report a higher quality of life. Although results were not statistically significant, patients who received the intervention had fewer and shorter unplanned hospital admissions. Conclusions: This trial is the first of its kind to demonstrate the effectiveness of a psychological intervention to improve nutrition in patients with HNC who are receiving RT. The intervention provides a means to ameliorate malnutrition and the important related outcomes and consequently should be incorporated into standard care for patients receiving RT for HNC