Taxonomic clarification in W-Mediterranean Androcymbium (Colchicaceae): A. wyssianum sunk in the synonymy of A.gramineum and A.europaeum restored

Capsule dehiscence has been used as a diagnostic character for W Mediterranean species of Androcymbium. Depending on the state of capsule maturity, the character, however, can be ambiguous in herbarium material. Based on morphological, phenological and cpDNA characters it is shown that misinterpretation of the capsule as indehiscent in the type material of A. gramineum has led to serious taxonomic confusion. The combined analyses produced evidence that A. gramineum of the population from the type locality at Essaouira, Morocco, is conspecific with A. wyssianum. A. gramineum is therefore the correct name for the species with dehiscent capsules, whereas the populations with indehiscent capsules at the Atlantic coast north of Essaouira and in SE Spain represent a second species, which is correctly named A. europaeu

Robert Chodat

Beauverd G. Robert Chodat. In: Le Globe. Revue genevoise de géographie, tome 73, 1934. pp. 28-30

SOCI\uc9T\uc9 BOTANIQUE DE GEN\uc8VE. Compte rendu des s\ue9ances. — 9 novembre 1908

Volume: 8Start Page: 973End Page: 99

Robert Chodat

Beauverd G. Robert Chodat. In: Le Globe. Revue genevoise de géographie, tome 73, 1934. pp. 28-30

NOUVELLES ESP\uc8CES URUGUAYENNES DU GENRE NOTHQSGORDUM KUNTH (Avec gravures dans le texte)

Volume: 8Start Page: 993End Page: 100

LE BUIS DANS LE BASSIN DE SALLANCHES (Haute-Savoie)

Volume: 8Start Page: 624End Page: 62

Expression hierarchy of T cell epitopes from melanoma differentiation antigens: unexpected high level presentation of tyrosinase-HLA-A2 Complexes revealed by peptide-specific, MHC-restricted, TCR-like antibodies.

Peptide Ags presented by class I MHC molecules on human melanomas and that are recognized by CD8(+) T cells are the subjects of many studies of antitumor immunity and represent attractive candidates for therapeutic approaches. However, no direct quantitative measurements exist to reveal their expression hierarchy on the cell surface. Using novel recombinant Abs which bind these Ags with a peptide-specific, MHC-restricted manner, we demonstrate a defined pattern of expression hierarchy of peptide-HLA-A2 complexes derived from three major differentiation Ags: gp100, Melan-A/Mart-1, and tyrosinase. Studying melanoma cell lines derived from multiple patients, we reveal a surprisingly high level of presentation of tyrosinase-derived complexes and moderate to very low expression of complexes derived from other Ags. No correlation between Ag presentation and mRNA expression was found; however, protein stability may play a major role. These results provide new insights into the characteristics of Ag presentation and are particularly important when such targets are being considered for immunotherapy. These results may shed new light on relationships between Ag presentation and immune response to cancer Ags