Incorporación del estudio de ADN fetal en sangre materna al cribado de cromosomopatías

Objetivo: Evaluar la efectividad del cribado combinado de primer trimestre para la detección prenatal de aneuploidías tras 6 años de implantación en nuestro servicio y su repercusión en la disminución de pruebas diagnósticas invasivas. Se propone establecer un protocolo para incorporar el estudio de ADN fetal en sangre materna a partir de las revisiones bibliográficas publicadas. Método: Se evaluó el riesgo de anomalía cromosómica fetal en 3177 gestaciones mediante cribado combinado de primer trimestre entre enero de 2011 y diciembre de 2014. Se revisaron las amniocentesis realizadas desde que se instauró el cribado combinado en 2008 comparándolas con las de los 5 años anteriores. Resultados: La tasa de detección del cribado para trisomía 21 fue del 94,4% y la tasa de falsos positivos de 6,4%. En el año 2005 estábamos realizando 194 amniocentesis, tras 6 años de implantación del cribado, en el año 2013 se realizaron 35 amniocentesis lo que implica una disminución del 70%. Conclusiones: El cribado combinado de primer trimestre ha demostrado una mayor tasa de detección para trisomía 21 que el cribado de segundo trimestre y/o la edad materna, además de que ha llevado a una importante reducción en el número de pruebas invasivas. En los próximos años la incorporación del estudio de ADN fetal mejorará la detección de aneuploidías, con una drástica disminución de las pruebas invasivas por lo que se hace necesario la implantación de nuevos protocolos. Aims: To evaluate the effectiveness of first trimester combined screening in the prenatal detection of aneuploidy after 6 years of implantation in our service and its impact in reducing invasive diagnostic tests. It is proposed to establish a protocol to incorporate the study of fetal DNA in maternal blood from published literature reviews. Methods: The risk of fetal chromosomal anomalies was assessed in 3177 pregnancies with first trimester combined screening between January 2009 and December 2014. The amniocenteses performed were checked against those of the previous 5 years. Results: The detection rate of screening for trisomy 21 was 94.4% and the false-positive rate was 6.4%. In 2005 there were 194 amniocenteses. In 2013, 5 years after the introduction of screening, 68 amniocenteses were performed, representing a 70% reduction in invasive procedures. Conclusions: First trimester combined screening has shown a higher detection rate for trisomy 21 that the second trimester screening and/or maternal age, and has substantially reduced the use of invasive prenatal diagnostics procedures. In the coming years, the incorporation of the study of fetal DNA improve the detection of aneuploidys with a drastic reduction of invasive tests so that, the implementation of new protocols is necessary

A measurement of ΔΓs\Delta \Gamma_{s}

Using a dataset corresponding to 9 fb$^{−1}$ of integrated luminosity collected with the LHCb detector between 2011 and 2018 in proton-proton collisions, the decay-time distributions of the decay modes ${B}_s^0\to J/{\psi \eta}^{\prime }$ and ${B}_s^0\to J/\psi {\pi}^{+}{\pi}^{-}$ are studied. The decay-width difference between the light and heavy mass eigenstates of the ${B}_s^0$ meson is measured to be ∆Γ$_{s}$ = 0.087 ± 0.012 ± 0.009 ps$^{−1}$, where the first uncertainty is statistical and the second systematic.[graphic not available: see fulltext]Using a dataset corresponding to $9~\mathrm{fb}^{-1}$ of integrated luminosity collected with the LHCb detector between 2011 and 2018 in proton-proton collisions, the decay-time distributions of the decay modes $B_s^0 \rightarrow J/\psi \eta'$ and $B_s^0 \rightarrow J/\psi \pi^{+} \pi^{-}$ are studied. The decay-width difference between the light and heavy mass eigenstates of the $B_s^0$ meson is measured to be $\Delta \Gamma_s = 0.087 \pm 0.012 \pm 0.009 \, \mathrm{ps}^{-1}$, where the first uncertainty is statistical and the second systematic

Observation of Ξb0→Ξc+Ds−\Xi_b^0 \rightarrow \Xi_c^+ D_s^- and Ξb−→Ξc0Ds−\Xi_b^- \rightarrow \Xi_c^0 D_s^- decays

International audienceThe $\Xi_b^0 \rightarrow \Xi_c^+ D_s^-$ and $\Xi_b^- \rightarrow \Xi_c^0 D_s^-$ decays are observed for the first time using proton-proton collision data collected by the LHCb experiment at a centre-of-mass energy of $\sqrt{s}=13\mathrm{TeV}$, corresponding to an integrated luminosity of $5.1\mathrm{fb}^{-1}$. The relative branching fractions times the beauty-baryon production cross-sections are measured to be \begin{align*} \mathcal{R}\left(\frac{\Xi_b^0}{\Lambda_b^0}\right) \equiv \frac{\sigma\left(\Xi_b^0\right)}{\sigma\left(\Lambda_b^0\right)} \times \frac{\mathcal{B}\left(\Xi_b^0 \rightarrow \Xi_c^+ D_s^-\right)}{\mathcal{B}\left(\Lambda_b^0 \rightarrow \Lambda_c^0 D_s^-\right)} =(15.8\pm1.1\pm0.6\pm7.7)\%, \mathcal{R}\left(\frac{\Xi_b^-}{\Lambda_b^0}\right) \equiv \frac{\sigma\left(\Xi_b^-\right)}{\sigma\left(\Lambda_b^0\right)} \times \frac{\mathcal{B}\left(\Xi_b^- \rightarrow \Xi_c^0 D_s^-\right)}{\mathcal{B}\left(\Lambda_b^0 \rightarrow \Lambda_c^0 D_s^-\right)} =(16.9\pm1.3\pm0.9\pm4.3)\%, \end{align*} where the first uncertainties are statistical, the second systematic, and the third due to the uncertainties on the branching fractions of relevant charm-baryon decays. The masses of $\Xi_b^0$ and $\Xi_b^-$ baryons are measured to be $m_{\Xi_b^0}=5791.12\pm0.60\pm0.45\pm0.24\mathrm{MeV}/c^2$ and $m_{\Xi_b^-}=5797.02\pm0.63\pm0.49\pm0.29\mathrm{MeV}/c^2$, where the uncertainties are statistical, systematic, and those due to charm-hadron masses, respectively

Observation of Ξb0→Ξc+Ds−\Xi_b^0 \rightarrow \Xi_c^+ D_s^- and Ξb−→Ξc0Ds−\Xi_b^- \rightarrow \Xi_c^0 D_s^- decays

International audienceThe $\Xi_b^0 \rightarrow \Xi_c^+ D_s^-$ and $\Xi_b^- \rightarrow \Xi_c^0 D_s^-$ decays are observed for the first time using proton-proton collision data collected by the LHCb experiment at a centre-of-mass energy of $\sqrt{s}=13\mathrm{TeV}$, corresponding to an integrated luminosity of $5.1\mathrm{fb}^{-1}$. The relative branching fractions times the beauty-baryon production cross-sections are measured to be \begin{align*} \mathcal{R}\left(\frac{\Xi_b^0}{\Lambda_b^0}\right) \equiv \frac{\sigma\left(\Xi_b^0\right)}{\sigma\left(\Lambda_b^0\right)} \times \frac{\mathcal{B}\left(\Xi_b^0 \rightarrow \Xi_c^+ D_s^-\right)}{\mathcal{B}\left(\Lambda_b^0 \rightarrow \Lambda_c^0 D_s^-\right)} =(15.8\pm1.1\pm0.6\pm7.7)\%, \mathcal{R}\left(\frac{\Xi_b^-}{\Lambda_b^0}\right) \equiv \frac{\sigma\left(\Xi_b^-\right)}{\sigma\left(\Lambda_b^0\right)} \times \frac{\mathcal{B}\left(\Xi_b^- \rightarrow \Xi_c^0 D_s^-\right)}{\mathcal{B}\left(\Lambda_b^0 \rightarrow \Lambda_c^0 D_s^-\right)} =(16.9\pm1.3\pm0.9\pm4.3)\%, \end{align*} where the first uncertainties are statistical, the second systematic, and the third due to the uncertainties on the branching fractions of relevant charm-baryon decays. The masses of $\Xi_b^0$ and $\Xi_b^-$ baryons are measured to be $m_{\Xi_b^0}=5791.12\pm0.60\pm0.45\pm0.24\mathrm{MeV}/c^2$ and $m_{\Xi_b^-}=5797.02\pm0.63\pm0.49\pm0.29\mathrm{MeV}/c^2$, where the uncertainties are statistical, systematic, and those due to charm-hadron masses, respectively

Prompt and nonprompt ψ(2S)\psi(2S) production in ppPb collisions at sNN=8.16\sqrt{s_{NN}}=8.16 TeV

International audienceThe production of $\psi(2S)$ mesons in proton-lead collisions at a centre-of-mass energy per nucleon pair of $\sqrt{s_{NN}}=8.16$ TeV is studied with the LHCb detector using data corresponding to an integrated luminosity of 34 nb$^{-1}$. The prompt and nonprompt $\psi(2S)$ production cross-sections and the ratio of the $\psi(2S)$ to $J/\psi$ cross-section are measured as a function of the meson transverse momentum and rapidity in the nucleon-nucleon centre-of-mass frame, together with forward-to-backward ratios and nuclear modification factors. The production of prompt $\psi(2S)$ is observed to be more suppressed compared to $pp$ collisions than the prompt $J/\psi$ production, while the nonprompt productions have similar suppression factors

Measurement of associated J/ψJ/\psi-ψ(2S)\psi(2S) production cross-section in pppp collisions at s=13\sqrt{s}=13 TeV

International audienceThe cross-section of associated $J/\psi$-$\psi(2S)$ production in proton-proton collisions at a centre-of-mass energy of $\sqrt{s}=13$ TeV is measured using a data sample corresponding to an integrated luminosity of 4.2 fb$^{-1}$, collected by the LHCb experiment. The measurement is performed for both $J/\psi$ and $\psi(2S)$ mesons having transverse momentum $p_{\text{T}}<14$ GeV/$c$ and rapidity $2.0<y<4.5$, assuming negligible polarisation of the $J/\psi$ and $\psi(2S)$ mesons. The production cross-section is measured to be $4.5\pm0.7\pm0.3$ nb, where the first uncertainty is statistical and the second systematic. The differential cross-sections are measured as functions of several kinematic variables of the $J/\psi$-$\psi(2S)$ candidates. The results are combined with a measurement of $J/\psi$-$J/\psi$ production, giving a cross-section ratio between $J/\psi$-$\psi(2S)$ and $J/\psi$-$J/\psi$ production of $0.274\pm0.044\pm0.008$, where the first uncertainty is statistical and the second systematic

Observation of the decays B(s)0→Ds1(2536)∓K±B_{(s)}^{0}\to D_{s1}(2536)^{\mp}K^{\pm}

International audienceThis paper reports the observation of the decays $B_{(s)}^{0}\to D_{s1}(2536)^{\mp}K^{\pm}$ using proton-proton collision data collected by the LHCb experiment, corresponding to an integrated luminosity of $9\,\mathrm{fb}^{-1}$. The branching fractions of these decays are measured relative to the normalisation channel $B^{0}\to \overline{D}^{0}K^{+}K^{-}$. The $D_{s1}(2536)^{-}$ meson is reconstructed in the $\overline{D}^{*}(2007)^{0}K^{-}$ decay channel and the products of branching fractions are measured to be $$\mathcal{B}(B_{s}^{0}\to D_{s1}(2536)^{\mp}K^{\pm})\times\mathcal{B}(D_{s1}(2536)^{-}\to\overline{D}^{*}(2007)^{0}K^{-})=(2.49\pm0.11\pm0.12\pm0.25\pm0.06)\times 10^{-5},$$$$\mathcal{B}(B^{0}\to D_{s1}(2536)^{\mp}K^{\pm})\times\mathcal{B}(D_{s1}(2536)^{-}\to\overline{D}^{*}(2007)^{0}K^{-}) = (0.510\pm0.021\pm0.036\pm0.050)\times 10^{-5}.$$ The first uncertainty is statistical, the second systematic, and the third arises from the uncertainty of the branching fraction of the $B^{0}\to \overline{D}^{0}K^{+}K^{-}$ normalisation channel. The last uncertainty in the $B_{s}^{0}$ result is due to the limited knowledge of the fragmentation fraction ratio, $f_{s}/f_{d}$. The significance for the $B_{s}^{0}$ and $B^{0}$ signals is larger than $10\,\sigma$. The ratio of the helicity amplitudes which governs the angular distribution of the $D_{s1}(2536)^{-}\to\overline{D}^{*}(2007)^{0}K^{-}$ decay is determined from the data. The ratio of the $S$- and $D$-wave amplitudes is found to be $1.11\pm0.15\pm 0.06$ and its phase $0.70\pm0.09\pm 0.04$ rad, where the first uncertainty is statistical and the second systematic

Multiplicity dependence of σψ(2S)_{ψ(2S)}/σJ/ψ_{J/ψ} in pp collisions at s \sqrt{s} = 13 TeV

The ratio of production cross-sections of ψ(2S) over J/ψ mesons as a function of charged-particle multiplicity in proton-proton collisions at a centre-of-mass energy $\sqrt{s}$ = 13 TeV is measured with a data sample collected by the LHCb detector, corresponding to an integrated luminosity of 658 pb$^{−1}$. The ratio is measured for both prompt and non-prompt ψ(2S) and J/ψ mesons. When there is an overlap between the rapidity ranges over which multiplicity and charmonia production are measured, a multiplicity-dependent modification of the ratio is observed for prompt mesons. No significant multiplicity dependence is found when the ranges do not overlap. For non-prompt production, the ψ(2S)-to-J/ψ production ratio is roughly independent of multiplicity, irrespective of the rapidity range over which the multiplicity is measured. The results are compared to predictions of the co-mover model and agree well except in the low multiplicity region. The ratio of production cross-sections of ψ(2S) over J/ψ mesons are cross-checked with other measurements in di-lepton channels and found to be compatible.[graphic not available: see fulltext]The ratio of production cross-sections of $\psi(2S)$ over $J/\psi$ mesons as a function of charged-particle multiplicity in proton-proton collisions at a centre-of-mass energy $\sqrt{s}=13$ TeV is measured with a data sample collected by the LHCb detector, corresponding to an integrated luminosity of 658 pb$^{-1}$. The ratio is measured for both prompt and non-prompt $\psi(2S)$ and $J/\psi$ mesons. When there is an overlap between the rapidity ranges over which multiplicity and charmonia production are measured, a multiplicity-dependent modification of the ratio is observed for prompt mesons. No significant multiplicity dependence is found when the ranges do not overlap. For non-prompt production, the $\psi(2S)-to-J/\psi$ production ratio is roughly independent of multiplicity irrespective of the rapidity range over which the multiplicity is measured. The results are compared to predictions of the co-mover model and agree well except in the low multiplicity region. The ratio of production cross-sections of $\psi(2S)$ over $J/\psi$ mesons are cross-checked with other measurements in di-lepton channels and found to be compatible

Measurement of J/ψJ/\psi-pair production in pppp collisions at s=13\sqrt{s}=13 TeV and study of gluon transverse-momentum dependent PDFs

International audienceThe production cross-section of $J/\psi$ pairs in proton-proton collisions at a centre-of-mass energy of $\sqrt{s}=13$ TeV is measured using a data sample corresponding to an integrated luminosity of 4.2 fb$^{-1}$ collected by the LHCb experiment. The measurement is performed with both $J/\psi$ mesons in the transverse momentum range $0<p_{\text{T}}<14$ GeV/$c$ and rapidity range $2.0<y<4.5$. The cross-section of this process is measured to be 16.36$\pm$0.28(stat)$\pm$0.88(syst) nb. The contributions from single-parton scattering and double-parton scattering are separated based on the dependence of the cross-section on the absolute rapidity difference $\Delta y$ between the two $J/\psi$ mesons. The effective cross-section of double-parton scattering is measured to be $\sigma_{\text{eff}}=$13.1$\pm$1.8(stat)$\pm$2.3(syst) mb. The distribution of the azimuthal angle $\phi_{\text{CS}}$ of one of the $J/\psi$ mesons in the Collins-Soper frame and the $p_{\text{T}}$-spectrum of the $J/\psi$ pairs are also measured for the study of the gluon transverse-momentum dependent distributions inside protons. The extracted values of $\langle\cos2\phi_{\text{CS}}\rangle$ and $\langle\cos4\phi_{\text{CS}}\rangle$ are consistent with zero, but the presence of azimuthal asymmetry at a few percent level is allowed

Multiplicity dependence of σψ(2S)/σJ/ψ\sigma_{\psi(2S)}/\sigma_{J/\psi} in pppp collisions at s=13\sqrt{s}=13 TeV

International audienceThe ratio of production cross-sections of $\psi(2S)$ over $J/\psi$ mesons as a function of charged-particle multiplicity in proton-proton collisions at a centre-of-mass energy $\sqrt{s}=13$ TeV is measured with a data sample collected by the LHCb detector, corresponding to an integrated luminosity of 658 pb$^{-1}$. The ratio is measured for both prompt and non-prompt $\psi(2S)$ and $J/\psi$ mesons. When there is an overlap between the rapidity ranges over which multiplicity and charmonia production are measured, a multiplicity-dependent modification of the ratio is observed for prompt mesons. No significant multiplicity dependence is found when the ranges do not overlap. For non-prompt production, the $\psi(2S)-to-J/\psi$ production ratio is roughly independent of multiplicity irrespective of the rapidity range over which the multiplicity is measured. The results are compared to predictions of the co-mover model and agree well except in the low multiplicity region. The ratio of production cross-sections of $\psi(2S)$ over $J/\psi$ mesons are cross-checked with other measurements in di-lepton channels and found to be compatible