145 research outputs found
Run Time Approximation of Non-blocking Service Rates for Streaming Systems
Stream processing is a compute paradigm that promises safe and efficient
parallelism. Modern big-data problems are often well suited for stream
processing's throughput-oriented nature. Realization of efficient stream
processing requires monitoring and optimization of multiple communications
links. Most techniques to optimize these links use queueing network models or
network flow models, which require some idea of the actual execution rate of
each independent compute kernel within the system. What we want to know is how
fast can each kernel process data independent of other communicating kernels.
This is known as the "service rate" of the kernel within the queueing
literature. Current approaches to divining service rates are static. Modern
workloads, however, are often dynamic. Shared cloud systems also present
applications with highly dynamic execution environments (multiple users,
hardware migration, etc.). It is therefore desirable to continuously re-tune an
application during run time (online) in response to changing conditions. Our
approach enables online service rate monitoring under most conditions,
obviating the need for reliance on steady state predictions for what are
probably non-steady state phenomena. First, some of the difficulties associated
with online service rate determination are examined. Second, the algorithm to
approximate the online non-blocking service rate is described. Lastly, the
algorithm is implemented within the open source RaftLib framework for
validation using a simple microbenchmark as well as two full streaming
applications.Comment: technical repor
Modular e-learning for a practical skill in vascular surgery
Introduction: Working Time Regulations in Europe allied with the endovascular revolution require vascular surgeons to
be innovative in achieving competence during their training period. We evaluated the feasibility of eLearning to teach
the use of OsiriX for sizing and planning endovascular aortic aneurysm repairs.
Materials and Methods: Eight blended learning modules were constructed, consisting of instructional PDFs, demonstration
videos, CT angiogram downloads for individual practice and online support forums. These were delivered online
over a nine-week period. The learning material encompassed an introduction to the OsiriX interface, the basic skills to
use OsiriX for sizing and planning of aneurysm repairs and advanced techniques for reconstruction and online communication
relating to imaging.
Results: The course was successfully delivered and produced positive feedback from registered users. A high rate of
dropouts occurred during the early phase. The design and implementation of a fully web-based course by full time clinicians
utilising multimedia and user forums to teach vascular surgeons the performance of a practical skill is feasible.
Conclusions: A modular instructional course offered online by vascular surgeons is feasible in teaching clinicians the use
of OsiriX for 3D reconstructions of CT angiograms of aortic aneurysms. Shortening course duration may improve compliance.
The instructional model is effective and well received by compliant learners
Clinical effectiveness and cost-effectiveness of open and arthroscopic rotator cuff repair [the UK Rotator Cuff Surgery (UKUFF) randomised trial]
Peer reviewedPublisher PD
Cost-effectiveness of replacing versus discarding the nail in children with nail bed injury
Every year in the UK, around 10 000 children need to have operations to mend injuries to the bed of their fingernails. Currently, most children have their fingernail placed back on the injured nail bed after the operation. The NINJA trial found that children were slightly less likely to have an infection if the nail was thrown away rather than being put back, but the difference between groups was small and could have be due to chance. This study looked at whether replacing the nail is cost-effective compared with throwing it away. Using data from the NINJA trial, we compared costs, healthcare use, and quality of life and assessed the cost-effectiveness of replacing the nail. It was found that throwing the nail away after surgery would save the National Health Service (NHS) £75 (€85) per operation compared with placing the nail back on the nail bed. Changing clinical practice could save the NHS in England £720 000 (€819 000) per year
Persistent starspot signals on M dwarfs: multi-wavelength Doppler observations with the Habitable-zone Planet Finder and Keck/HIRES
Young, rapidly-rotating M dwarfs exhibit prominent starspots, which create
quasiperiodic signals in their photometric and Doppler spectroscopic
measurements. The periodic Doppler signals can mimic radial velocity (RV)
changes expected from orbiting exoplanets. Exoplanets can be distinguished from
activity-induced false positives by the chromaticity and long-term incoherence
of starspot signals, but these qualities are poorly constrained for
fully-convective M stars. Coherent photometric starspot signals on M dwarfs may
persist for hundreds of rotations, and the wavelength dependence of starspot RV
signals may not be consistent between stars due to differences in their
magnetic fields and active regions. We obtained precise multi-wavelength RVs of
four rapidly-rotating M dwarfs (AD Leo, G 227-22, GJ 1245B, GJ 3959) using the
near-infrared (NIR) Habitable-zone Planet Finder, and the optical Keck/HIRES
spectrometer. Our RVs are complemented by photometry from Kepler, TESS, and the
Las Cumbres Observatory (LCO) network of telescopes. We found that all four
stars exhibit large spot-induced Doppler signals at their rotation periods, and
investigated the longevity and optical-to-NIR chromaticity for these signals.
The phase curves remain coherent much longer than is typical for Sunlike stars.
Their chromaticity varies, and one star (GJ 3959) exhibits optical and NIR RV
modulation consistent in both phase and amplitude. In general, though, we find
that the NIR amplitudes are lower than their optical counterparts. We conclude
that starspot modulation for rapidly-rotating M stars frequently remains
coherent for hundreds of stellar rotations, and gives rise to Doppler signals
that, due to this coherence, may be mistaken for exoplanets.Comment: Accepted for publication in the Astrophysical Journa
A systematic review of the use of an expertise-based randomised controlled trial design
Acknowledgements JAC held a Medical Research Council UK methodology (G1002292) fellowship, which supported this research. The Health Services Research Unit, Institute of Applied Health Sciences (University of Aberdeen), is core-funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates. Views express are those of the authors and do not necessarily reflect the views of the funders.Peer reviewedPublisher PD
Length of carotid stenosis predicts peri-procedural stroke or death and restenosis in patients randomized to endovascular treatment or endarterectomy.
BACKGROUND: The anatomy of carotid stenosis may influence the outcome of endovascular treatment or carotid endarterectomy. Whether anatomy favors one treatment over the other in terms of safety or efficacy has not been investigated in randomized trials.
METHODS: In 414 patients with mostly symptomatic carotid stenosis randomized to endovascular treatment (angioplasty or stenting; n = 213) or carotid endarterectomy (n = 211) in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS), the degree and length of stenosis and plaque surface irregularity were assessed on baseline intraarterial angiography. Outcome measures were stroke or death occurring between randomization and 30 days after treatment, and ipsilateral stroke and restenosis ≥50% during follow-up. RESULTS: Carotid stenosis longer than 0.65 times the common carotid artery diameter was associated with increased risk of peri-procedural stroke or death after both endovascular treatment [odds ratio 2.79 (1.17-6.65), P = 0.02] and carotid endarterectomy [2.43 (1.03-5.73), P = 0.04], and with increased long-term risk of restenosis in endovascular treatment [hazard ratio 1.68 (1.12-2.53), P = 0.01]. The excess in restenosis after endovascular treatment compared with carotid endarterectomy was significantly greater in patients with long stenosis than with short stenosis at baseline (interaction P = 0.003). Results remained significant after multivariate adjustment. No associations were found for degree of stenosis and plaque surface.
CONCLUSIONS: Increasing stenosis length is an independent risk factor for peri-procedural stroke or death in endovascular treatment and carotid endarterectomy, without favoring one treatment over the other. However, the excess restenosis rate after endovascular treatment compared with carotid endarterectomy increases with longer stenosis at baseline. Stenosis length merits further investigation in carotid revascularisation trials
Intelligent Cooperative Control Architecture: A Framework for Performance Improvement Using Safe Learning
Planning for multi-agent systems such as task assignment for teams of limited-fuel unmanned aerial vehicles (UAVs) is challenging due to uncertainties in the assumed models and the very large size of the planning space. Researchers have developed fast cooperative planners based on simple models (e.g., linear and deterministic dynamics), yet inaccuracies in assumed models will impact the resulting performance. Learning techniques are capable of adapting the model and providing better policies asymptotically compared to cooperative planners, yet they often violate the safety conditions of the system due to their exploratory nature. Moreover they frequently require an impractically large number of interactions to perform well. This paper introduces the intelligent Cooperative Control Architecture (iCCA) as a framework for combining cooperative planners and reinforcement learning techniques. iCCA improves the policy of the cooperative planner, while reduces the risk and sample complexity of the learner. Empirical results in gridworld and task assignment for fuel-limited UAV domains with problem sizes up to 9 billion state-action pairs verify the advantage of iCCA over pure learning and planning strategies
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