Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system.

Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection. One of the principal factors that control the outcome of infection is the localized tissue response and subsequent immune response directed against the invading toxic agent. It is the role of the immune system to contain and control the spread of virus infection in the central nervous system (CNS), and paradoxically, this response may also be pathologic. Chemokines are potent proinflammatory molecules whose expression within virally infected tissues is often associated with protection and/or pathology which correlates with migration and accumulation of immune cells. Indeed, studies with a neurotropic murine coronavirus, mouse hepatitis virus (MHV), have provided important insight into the functional roles of chemokines and chemokine receptors in participating in various aspects of host defense as well as disease development within the CNS. This chapter will highlight recent discoveries that have provided insight into the diverse biologic roles of chemokines and their receptors in coordinating immune responses following viral infection of the CNS

Synthesis of cationic conjugated polymers for use in label-free DNA microarrays

10.1038/nprot.2006.272Nature Protocols141698-170

Preface

10.1002/9783527655700Conjugated Polyelectrolytes: Fundamentals and ApplicationsXIII-XI

Collective response from a cationic tetrahedral fluorene for label-free DNA detection

10.1002/adfm.200600821Advanced Functional Materials17142432-2438AFMD

Molecular design of antimicrobial conjugated oligoelectrolytes with enhanced selectivity toward bacterial cells

10.1039/d0sc03679jChemical Science11318138-814

Recent advances in conjugated polyelectrolytes for emerging optoelectronic applications

10.1021/cm102196tChemistry of Materials233501-515CMAT

Resonance Raman, hyper-Raman, and hyper-Rayleigh depolarization ratios and symmetry breaking in solution

International audienc

Conjugated Polyelectrolyte Graphene Hetero Bilayer Nanocomposites Exhibit Temperature Switchable Type of Conductivity

Conjugated polyelectrolytes CPEs comprise an electronically delocalized backbone that is rendered soluble in high dielectric media through the incorporation of side groups bearing ionic functionalities. This combination of structural components yields soft materials capable of integrating the optoelectronic features of organic semiconductors with the ability of polyelectrolytes to modulate physical properties through electrostatic forces. CPEs have been used to control charge injection barriers in organic optoelectronic devices through interfacial phenomena in which electrostatic dipoles modify the effective work function of adjacent metallic electrodes. Doping preferences of the backbone can also be influenced by the choice of the charged group closest to the backbone, as demonstrated by narrow bandgap molecular frameworks that spontaneously p dope in water when containing anionic side groups, but remain undoped in the case of the cationic counterparts. These doping preferences also extend to single walled carbon nanotube SWNT composites, where the cationic anionic CPE yields n type p type nanocomposites, despite that the same conjugated framework is utilize

Nanoscale insight into intermolecular interactions in organic photovoltaic blends using solid state NMR spectroscopy

International audienc