Kikuchi Fujimato Disease

Kikuchi Fujimato disease (KFD) also know as histiocytic necrotizing lymphadenitis (HNL) is a benign, self limiting disease, which commonly affects young women under 30 years of age. Most of the cases resolve in a six month period. Laboratory and clinical findings of KFD show similarities with tuberculosis lymphadenitis, mailgn lymphoma, other malign and benign diseases. The diagnosis is established on the basis of histology of lymph node excisional biopsy. The differentiation of KFD from Sistemik Lupus Eritematosus (SLE) can sometimes be problematic because both can show similar clinical and histological features. KFD and SLE can be seen together. Forty two years-old female patient diagnosed with KFD was discussed in light of current literature

An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats

ObjectivesIn this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats.MethodsThirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no treatment). Thymoquinone was fed to the rats via oral gavage in a dose of 40 mg/kg/day throughout the study period of 14 days. Amikacin was given by the intramuscular route in a dose of 600 mg/kg/day. Audiological assessment was conducted by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests, administered to all rats at the beginning of the study, and also on days 7 and 15. Biochemical parameters were calculated at the termination of the study to evaluate the oxidative status.ResultsThere were significant decreases in DPOAE values and significant increases in ABR thresholds of the amikacin group on days 7 and 15, as compared to the amikacin+thymoquinone group. While ABR thresholds of the amikacin group increased significantly on days 7 and 15 as compared to their initial values, there were no significant differences between the initial and the 7th and 15th day values of ABR thresholds in the amikacin+thymoquinone group. Total oxidant status and oxidative stress index values of the amikacin+thymoquinone group were significantly lower than those of the amikacin group. Total antioxidant status values of the amikacin+thymoquinone group were significantly higher than those of the amikacin group.ConclusionOur study has demonstrated that the ototoxic effect brought forth by amikacin could be overcome with the concurrent use of thymoquinone

Laryngofissure Cordectomy-Evaluations of Positive Margins and Survival Rates

Objective: The primary aim of this study was to evaluate the results of early-stage glottic laryngeal cancer patients who underwent laryngofissure cordectomy. Results were analyzed in terms of positive margins and survival rates

Nonodontogenic Cervical Necrotizing Fasciitis Caused by Sialadenitis

Necrotizing fasciitis is a rapidly progressive infectious disease of the soft tissue with high mortality and morbidity rates. Necrotizing fasciitis is occasionally located in the head and neck region and develops after odontogenic infections. Factors affecting treatment success rates are early diagnosis, appropriate antibiotic treatment, and surgical debridement. We present a necrotizing fasciitis case located in the neck region that developed after sialoadenitis. It is important to emphasize that necrotizing fasciitis to be seen in the neck region is very rare. Nonodontogenic necrotizing fasciitis is even more rare

Nonodontogenic Cervical Necrotizing Fasciitis Caused by Sialadenitis

Necrotizing fasciitis is a rapidly progressive infectious disease of the soft tissue with high mortality and morbidity rates. Necrotizing fasciitis is occasionally located in the head and neck region and develops after odontogenic infections. Factors affecting treatment success rates are early diagnosis, appropriate antibiotic treatment, and surgical debridement. We present a necrotizing fasciitis case located in the neck region that developed after sialoadenitis. It is important to emphasize that necrotizing fasciitis to be seen in the neck region is very rare. Nonodontogenic necrotizing fasciitis is even more rare

Our Experience in Parotid Gland Surgery: Analysis of 128 Cases

Aim: Salivary Gland tumors are occasionally seen. They constitute approximately 3% of all head and neck tumors. This study presents the clinical characteristics of 128 patotid gland masses diagnosed and treated in our clinic. Methods: The files of 128 patients, who underwent parotidectomy for parotid gland mass in the First Ear-Nose-Throat Clinic of the Haseki Training and Research Hospital between January 2000 and January 2010, were reviewed retrospectively. The routine Ear-Nose-Throat examinations, the ultrasonography findings, the fine-needle aspiration biopsy results and those of the pathological examinations of the cases were assessed. Results: 67 of the cases were female and 61 were male. The youngest patient was 12-year-old and the oldest patient was 77-year-old; the mean age was 49.4 years. The mean follow-up time was 5.9 years. 109 of the detected masses were benign, while 19 of them were malignant. The most frequent benign tumor was pleomorphic adenoma; on the other hand, the most common malignant tumor was mucoepidermiod carcinoma. Conclusion: Due to the fact that the tumors originating from the parotid gland demonstrate histologic diversity, that they are seen occasionally and the pre-operative diagnosis is difficult, it is hard to develop a standard treatment protocol. (The Medical Bulletin of Haseki 2010; 48: 24-7

Medical ozone therapy for the inner ear acoustic trauma

WOS: 000324363400025PubMed ID: 23871516Objectives: The goal of the study was to look at the potential protective effect of ozone therapy by studying its antioxidant and vasodilatation effects against hearing loss caused by acoustic trauma. Methods: Thirty-two male Wistar Albino rats were divided into four groups of eight. The 1st group was exposed to acoustic trauma, the 2nd group was treated with ozone initially, and was exposed to acoustic trauma 24 h later, the 3rd group received ozone without trauma, while the 4th group was the control group. The 1st and 2nd groups were exposed to acoustic trauma with 105 dB SPL white band noise for 4 h. DPOAE and ABR tests were conducted in all groups on the 1st, 5th, and 10th days after trauma. Results: In the 1st group, the effects of acoustic trauma continued on days 1, 5 and 10. The 2nd group's DPOAE and ABR results on days 5 and 10 showed significant improvement at all frequencies compared to deterioration on day 1, and the readings were comparable to baseline measurements. Conclusion: Acoustic trauma is a pathology that is experienced frequently and leads to many problems in terms of health and cost. Ozone was demonstrated to be a reparative substance against acoustic trauma and, in addition, it can be supplied and applied easily

Effect of Recurrent Laryngeal Nerve Identification Technique in Thyroidectomy on Recurrent Laryngeal Nerve Paralysis and Hypoparathyroidism

Objective: To investigate whether the recurrent laryngeal nerve (RLN) identification technique used in thyroidectomy affects RLN paralysis and hypoparathyroidism