Assesment of Castellani Solution's Ototoxic Effects on Guinea Pigs Using Otoacoustic Emission and Auditory Evoked Brainstem Potentials

Objective: We planned to evaluate the ototoxic effects of Castellani's solution on guinea pigs when used intratympanically

The Malignancy Risk Assessment Of Cytologically Indeterminate Thyroid Nodules Improves Markedly By Using A Predictive Model

Objectives: The majority of thyroid nodules are discovered incidentally, and the management may be a challenge if the fine needle aspiration specimen yields indeterminate findings. Our aim was to develop an individualized risk prediction model to provide an accurate estimate of cancer risk in patients with cytologically indeterminate thyroid nodules. Materials and Methods: Clinical records, ultrasound images, and cytopathology reports of patients who underwent thyroidectomy were retrospectively reviewed. Logistic regression analysis was used to identify the predictive ability of each variable for malignancy, and a nomogram was built by integrating patients' age, multiplicity of nodules, cytology results, and suspicious ultrasound features, such as microcalcifications and irregular margins. Results: For the 233 indeterminate nodules according to the Bethesda System for Reporting Thyroid Cytopathology, the malignancy rates of the subgroups “atypia of undetermined significance,” “suspicious follicular neoplasia,” and “suspicious for malignancy” were 44.3, 47.7, and 88.0%, respectively. It was found that the Bethesda category “suspicious for malignancy,” microcalcifications, and irregular margins were independent risk factors for malignancy. The area under the receiver operating characteristics curve was 0.784, which suggested that the presented nomogram had considerable discriminative performance. Conclusions: The nomogram developed in our study accurately predicts the malignancy risk of thyroid nodules with indeterminate cytology by using clinical, cytological, and ultrasonographic features. (C) 2018 European Thyroid Association Published by S. Karger AG, BaselWo

Protective/Restorative Role of the Adipose Tissue-Derived Mesenchymal Stem Cells on the Radioiodine-Induced Salivary Gland Damage in Rats

Background. To analyze protective/regenerative effects of adipose tissue-derived mesenchymal stem cells (ADMSC) on I-131-Radioiodine (RAI)-induced salivary gland damage in rats. Materials and Methods. Study population consisted of controls (n: 6) and study groups (n: 54): RAI (Group 1), ADMSC (Group 2), amifostine (Group 3), RAI+ amifostine (Group 4), concomitant RAI+ ADMSC (Group 5) and RAI+ ADMSC after 48 h (Group 6). We used light microscopy (LM), transmission electron microscopy (TEM), and salivary gland scintigraphy (SGS), and analyzed data statistically. Results. We observed the homing of ADMSC in salivary glands at 1st month on LM. RAI exposure affected necrosis, periductal fibrosis, periductal sclerosis, vascular sclerosis and the total sum score were in a statistically significant manner (P 0.05). We observed a significant deterioration in gland function in group 1, whereas, mild to moderate deteriorations were seen in protective treatment groups. Conclusions. Our results indicated that ADMSC might play a promising role as a protective/regenerative agent against RAI-induced salivary gland dysfunction