OPTIMIZATION OF DISTANT RADIOTHERAPY PLANNING BY THE gEUD FUNCTION

The use of the generalized equivalent uniform dose (gEUD) function is promising approach for radiotherapy planning. The aim of the study is to evaluate gEUD-optimization of radiation therapy planning for prostate cancer and head and neck cancer

Postcovid physical rehabilitation at the sanatorium

New coronavirus infection caused by SARS-CoV-2 with severe complications was wide spread among the world's population and requires not only the improvement of treatment and prevention measures of the disease, but also the effective physical rehabilitation of post-COVID patients in a sanatorium. Research aim: to evaluate the effective-ness of early complex physical rehabilitation of persons with a post-COVID state in the sanatorium. Research materials and methods. The research project was carried out in «Darasun» sanatorium (Zabaikalsky Region, Russia). 33 people participated, including women 52.8±9.2 years old (n=16), men 51.5±9.0 year sold (n=17), who underwent a three-week course of early complex rehabilitation immediately after discharge from a medical institutions. The milestone testing of the functional indicators of the cardiorespiratory system, physical performance was carried out, anthropometric parameters, the level of quality of life and the degree of exercise tolerance were determined. Research results. At the end of the complex health-improving and rehabilitation measures, a positive change in the activity of the cardiovascular and respiratory systems was found in all project participants. Every week there was a positive increase in the level of exercise tolerance in the 6MWD test. At the end of the third week, the number of all participants’ steps increased by 50%, respiratory rate at rest decreased by 20%, blood oxygen saturation increased, blood pressure stabilized and quality of life improved by 52.5% in men and 34.8% in women, the exercise tolerance on the Borg scale became significantly higher. Conclusions. The use of an early comprehensive post-COVID program according to the proposed sanatorium physical rehabilitation protocol reduces the recovery time for people who have had a COVID infection and it is an effective method for returning patients to society

High rate dose brachytherapy - HDR experience for localized and locally advanced prostate cancer in Sverdlovsk Regional Oncology Dispensary

Currently, the rate of morbidity and mortality from prostate cancer has been increasing. HDR brachytherapy (HDR-ВТ) is considered to be one of the modern methods in the treatment of prostate cancer. In Sverdlovsk Regional Oncology Centre (SROC) this method has been being applied since 2009. In our work we analyzed treatment outcomes in 204 patients with localized and locally advanced prostate cancer after HDR as a single method as well as a part of combined and complex treatment. Our results evidenced of HDR brachytherapy as an effective and safe method of treatment, which improves hospitalization.В настоящее время в России отмечается рост заболеваемости и смертности от рака предстательной железы. Одним из современных методов лечения данной патологии является внутритканевая высокодозная брахитерапия - HDR (High dose rate). В Свердловском областном онкологическом диспансере (СООД) этот метод лечения применяется с 2009 г. В данной работе приводится анализ результатов лечения 204 больных локальным и местно-распространенным раком простаты с применением HDR как в самостоятельном плане, так и в составе комбинированного и/или комплексного лечения. Полученные нами результаты свидетельствуют о том, что высокодозная брахитерапия - HDR является эффективным и безопасным методом лечения, не требующим длительных сроков госпитализации больных

Stereotactic body radiation therapy (SBRT) in the treatment of spine metastases at the linear accelerator in Sverdlovsk Regional Oncology Center

Modern technology of radiation therapy (IMRT, SBRT, etc) are used for patients receiving radical treatment program with an expected high oncological result. However, for patients with single metastases to the spine can be applied the strategy of conditionally radical treatment, including the achievement of full local control of metastatic lesion followed adequately chosen a specific treatment. In the last case, the survival rate can reach several years. In S00D we use the technique of stereotactic body radiotherapy with 2012 for patients with metastases in the vertebrae. Currently treated 32 people, the effectiveness of treatment was 90,6% in terms of relief of pain. The method is effective and relatively safe method of treatment allows to reduce treatment time.Современные технологии лучевой терапии (IMRT, SBRT и др) используются для пациентов, получающих радикальную программу лечения с ожидаемым высоким онкологическим результатом. Однако для пациентов с одиночными метастазами в позвоночник может быть применена стратегия условно-радикального лечения, включающая в себя достижение полного локального контроля метастатического очага с последующим адекватно подобранным специфическим лечением. В последнем случае выживаемость пациентов может достигать нескольких лет. В СООД мы используем методику стереотаксической лучевой терапии с 2012 года для пациентов метастазами в позвонки. В настоящее время пролечено 32 человека, эффективность лечения составила 90,6% в плане купирования болевого синдрома. Методика является эффективным и достаточно безопасным методом лечения, позволяет сократить сроки лечения

Change of the composition of surface layers of Fe-Mo-P-C amorphous alloy under creep conditions

Translated from Russian (Fiz. Khim. Obrab. Mater. 1996 (1) p. 127-131)Available from British Library Document Supply Centre-DSC:9023.190(VR-Trans--9088)T / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

Otoliths as object of EPR dosimetric research

Otoliths are the organs which fish use for hearing and keeping balance. Otoliths are the most calcified tissues in the fish body. In contrast to bones, otoliths are not affected by remodeling and, therefore, they are expected to accumulate any dose from ionizing radiation during lifetime. Therefore, EPR dosimetry with fish otoliths could be an important tool for dose reconstruction in radiobiology and radioecology. It could also provide useful information remediation actions to de-contaminate waterbodies. Consequently, in the present study, otoliths of three contaminated fish species (roach (Rutilus rutilus), pike (Esox lucius) and perch (Perca Fluviatilis)) were examined with Electron Paramagnetic Resonance (EPR) spectroscopy. The fish were caught at storage reservoirs of liquid radioactive waste from Mayak PA and from the upper reach of the Techa River, which have been contaminated with different levels of radionuclide activity concentrations. It is shown that the radiationinduced EPR signal of otolith is stable and characterized by a linear dose response. However, the slope of the calibration curve (corresponding to the radiation sensitivity of the material) is not the same for different species; this may be caused by differences in mineralization. The reconstructed doses were found to be in the range from undetectable (in fish from the upper stream of the Techa River) up to 265 Gy (in roach from the most contaminated waterbody). In parallel, otoliths were measured with beta-counter to detect Sr-90/Y-90. Samples were also tested on the presence of alpha-emitters, but no alpha activity above background could be detected. However, a significant activity concentration of Sr-90 was detected (from 1 x 10(1) to 2 x 10(4) Bq/g). The EPR doses measured correlated with the Sr-90 activity concentration measured in the otolith samples