An ASEAN Maritime Regime: Defusing Sino-US Rivalry in the South China Sea

The ASEAN is once again at the forefront of a super power rivalry, this time between the US and China with the South China Sea as its setting. Against the increasing security dilemma in the South China Sea and threat of great power rivalry, a change in the characterizationof the region’s security outlook from an essentially military definition to comprehensive security is necessary. This refers to interdependence and cooperation in economic development,scientific research, and a general enhancement of human interactions. The establishment of an ASEAN-led maritime regime against piracy could initiate the foundation for a resolution to theSouth China Sea disputes and encourage cooperation and foster understanding in Sino-US rivalry in the region

Relation between clinical features and gastric emptying time in diabetic patients

BACKGROUND: Gastroparesis is characterized by delayed gastric emptying. This pathology is usually observed in patients with diabetes. One standard approach to quantitative assessment of gastric emptying is scintigraphic study. The aim of present study was to perform scintigraphic study of gastric emptying time in patient with diabetes and to find its correlation with patients' characteristics. MATERIALS AND METHODS: Gastric emptying was assessed in 19 patients with type 2 diabetes (mean age of 61.04 ± 6.09 years) and 6 healthy volunteers. Characteristics of the patients were sex, age, duration of diabetes, blood sugar and serum HbA1c level. RESULTS: Results of present study revealed that gastric emptying half time was significantly larger in patients with type 2 diabetes as compared with healthy volunteers (P-value < 0.05). While correlation of sex, age, duration of diabetes and blood sugar with gastric emptying time was not statistically significant, HbA1c level had significant effect on gastric emptying time. CONCLUSION: Results of this prospective study indicated that level of serum HbA1c is an effecting factor on gastric emptying time in patients with type 2 diabetes; however, these preliminary findings should be validated in larger and well-designed studies. Copyright © 2015 Via Medica

Emergence of world-stock-market network

In the age of globalization, it is natural that the stock market of each country is not independent form the other markets. In this case, collective behavior could be emerged form their dependency together. This article studies the collective behavior of a set of forty influential markets in the world economy with the aim of exploring a global financial structure that could be called world-stock-market network. Towards this end, we analyze the cross-correlation matrix of the indices of these forty markets using Random Matrix Theory (RMT). We find the degree of collective behavior among the markets and the share of each market in their structural formation. This finding together with the results obtained from the same calculation on four stock markets reinforce the idea of a world financial market. Finally, we draw the dendrogram of the cross-correlation matrix to make communities in this abstract global market visible. The dendrogram, drawn by at least thirty percent of correlation, shows that the world financial market comprises three communities each of which includes stock markets with geographical proximity

Haptoglobin frequencies in Jewish communities *

Haptoglobin and transferrin types have been determined by starch gel electrophoresis on blood from 929 subjects belonging to various Jewish communities. The frequency of the Hp 1 gene in 499 Ashkenazic Jews is 0.29 and does not differ significantly from the value of 0–26 found in 345 Jews of Oriental origin. The Hp 1 frequency of Ashkenazic Jews is significantly lower than that reported for the autochthonous populations of Central and Western Europe. Two small samples collected among Sephardic Jews and among the offspring of intercommunity marriages exhibit somewhat higher frequencies of the Hp 1 gene. The modified 2-1 phenotype was found in a single subject from Baghdad. There were three cases of ahaptoglobinaemia among Ashkenazic Jews and three among the Oriental groups. No ahaptoglobinaemia was discovered in a family sample of ninety-two Jews from Kurdistan among whom thalassaemia minor was common and the majority of whom were affeeted with G-6-P-D deficiency. All transferrins were of type C.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66130/1/j.1469-1809.1962.tb01307.x.pd

Introduction of a Base-Model for Eddy Current Testing of Printed Circuits Boards

In this paper we propose a model to reproduce printed circuit board (PCB) pattern eddy current testing signals based on 3D finiteelement method (FEM) package and scanning simulation. In this method we consider some common PCB elements as test pieces while a simple Meander-type coil is utilized as excitation coil above the elements. Numerical solution to the above problem with the help of a 3D FEM provides the magnetic flux density in the region above the PCB test elements. Shifting the test element\u27s position step by step and repeating the numerical calculation for each of the test elements new positions, the scanning process of a PCB test piece is simulated. Analysing and smoothing the magnetic field data from all of the aforementioned steps provide the final PCB pattern signal. Image processing technique was applied to obtain the PCB part image

Dynamics of Hyporheic Flow and Heat Transport Across a Bed-to-Bank Continuum in a Large Regulated River

The lower Colorado River (LCR) near Austin, Texas is heavily regulated for hydropower generation. Daily water releases from a dam located 23 km upstream of our study site in the LCR caused the stage to fluctuate by more than 1.5 m about a mean depth of 1.3 m. As a result, the river switches from gaining to losing over a dam storage-release cycle, driving exchange between river water and groundwater. We assessed the hydrologic impacts of this by simultaneous temperature and head monitoring across a bed-to-bank transect. River-groundwater exchange flux is largest close to the bank and decreases away from the bank. Correspondingly, both the depth of the hyporheic zone and the exchange time are largest close to the bank. Adjacent to the bank, the streambed head response is hysteretic, with the hysteresis disappearing with distance from the bank, indicating that transient bank storage affects the magnitude and direction of vertical exchange close to the bank. Pronounced changes in streambed temperature are observed down to a meter. When the river stage is high, which coincides with when the river is coldest, downward advection of heat from a previous cycles\u27 warm-water pulse warms the streambed. When the river is at its lowest stage but warmest temperature, upwelling groundwater cools the streambed. Future research should consider and focus on a more thorough understanding of the impacts of dam regulation on the hydrologic, thermal, biogeochemical, and ecologic dynamics of rivers and their hyporheic and riparian zones

Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients

Background: Dysregulated expression of Kallikrein-related peptidase 6 (KLK6) is a common feature for many human malignancies and numerous studies evaluated KLK6 as a promising biomarker for early diagnosis or unfavorable prognosis. However, the expression of KLK6 in carcinomas derived from mucosal epithelia, including head and neck squamous cell carcinoma (HNSCC), and its mode of action has not been addressed so far. Methods: Stable clones of human mucosal tumor cell lines were generated with shRNA-mediated silencing or ectopic overexpression to characterize the impact of KLK6 on tumor relevant processes in vitro. Tissue microarrays with primary HNSCC samples from a retrospective patient cohort (n = 162) were stained by immunohistochemistry and the correlation between KLK6 staining and survival was addressed by univariate Kaplan-Meier and multivariate Cox proportional hazard model analysis. Results: KLK6 expression was detected in head and neck tumor cell lines (FaDu, Cal27 and SCC25), but not in HeLa cervix carcinoma cells. Silencing in FaDu cells and ectopic expression in HeLa cells unraveled an inhibitory function of KLK6 on tumor cell proliferation and mobility. FaDu clones with silenced KLK6 expression displayed molecular features resembling epithelial-to-mesenchymal transition, nuclear β-catenin accumulation and higher resistance against irradiation. Low KLK6 protein expression in primary tumors from oropharyngeal and laryngeal SCC patients was significantly correlated with poor progression-free (p = 0.001) and overall survival (p < 0.0005), and served as an independent risk factor for unfavorable clinical outcome. Conclusions: In summary, detection of low KLK6 expression in primary tumors represents a promising tool to stratify HNSCC patients with high risk for treatment failure. These patients might benefit from restoration of KLK6 expression or pharmacological targeting of signaling pathways implicated in EMT

Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer.

Dysregulation of the PI3K-AKT-mTOR signaling network is a prominent feature of breast cancers. However, clinical responses to drugs targeting this pathway have been modest, possibly because of dynamic changes in cellular signaling that drive resistance and limit drug efficacy. Using a quantitative chemoproteomics approach, we mapped kinome dynamics in response to inhibitors of this pathway and identified signaling changes that correlate with drug sensitivity. Maintenance of AURKA after drug treatment was associated with resistance in breast cancer models. Incomplete inhibition of AURKA was a common source of therapy failure, and combinations of PI3K, AKT or mTOR inhibitors with the AURKA inhibitor MLN8237 were highly synergistic and durably suppressed mTOR signaling, resulting in apoptosis and tumor regression in vivo. This signaling map identifies survival factors whose presence limits the efficacy of targeted therapies and reveals new drug combinations that may unlock the full potential of PI3K-AKT-mTOR pathway inhibitors in breast cancer