245 research outputs found

    HTR2008-58015 ROTOR SCALE MODEL TESTS FOR POWER CONVERSION UNIT OF GT-MHR

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    ABSTRACT A power-generating unit with the high-temperature helium reactor (GT-MHR) has a turbomachine (TM) that is intended for both conversion of coolant thermal energy into electric power in the direct gas-turbine cycle, and provision of helium circulation in the primary circuit. The vertically oriented TM is placed in the central area of the power conversion unit (PCU). TM consists of a turbocompressor (TC) and a generator. Their rotors are joined with a diaphragm coupling and supported by electro-magnetic bearings (EMB). The complexity and novelty of the task of the full electromagnetic suspension system development requires thorough stepwise experimental work, from small-scale physical models to full-scale specimen. On this purpose, the following is planned within the framework of the GT-MHR Project: investigations of the "flexible" rotor small-scale mockup with electro-magnetic bearings ("Minimockup" test facility); tests of the radial EMB; tests of the position sensors; tests of the TM rotor scale model; tests of the TM catcher bearings (CB) friction pairs; tests of the CB mockups; tests of EMB and CB pilot samples and investigation of the full-scale electromagnetic suspension system as a part of full-scale turbocompressor tests. The rotor scale model (RSM) tests aim at investigation of dynamics of rotor supported by electromagnetic bearings to validate GT-MHR turbomachine serviceability. Like the full-scale turbomachine rotor, the RSM consist of two parts: the generator rotor model and the turbocompressor rotor model that are joined with a coupling. Both flexible and rigid coupling options are tested. Each rotor is supported by one axial and two radial EMBs. The rotor is arranged vertically. The RSM rotor length is 10.54 m, and mass is 1171 kg. The designs of physical model elements, namely of the turbine, compressors, generator and exciter, are simplified and performed with account of rigid characteristics, which are identical to those of the full-scale turbomachine elements. INTRODUCTION A power-generating unit with the high-temperature helium reacto

    Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma

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    Rhabdomyosarcoma (RMS) is an aggressive pediatric malignancy of the muscle, that includes Fusion Positive (FP)-RMS harboring PAX3/7-FOXO1 and Fusion Negative (FN)-RMS commonly with RAS pathway mutations. RMS express myogenic master transcription factors MYOD and MYOG yet are unable to terminally differentiate. Here, we report that SNAI2 is highly expressed in FN-RMS, is oncogenic, blocks myogenic differentiation, and promotes growth. MYOD activates SNAI2 transcription via super enhancers with striped 3D contact architecture. Genome wide chromatin binding analysis demonstrates that SNAI2 preferentially binds enhancer elements and competes with MYOD at a subset of myogenic enhancers required for terminal differentiation. SNAI2 also suppresses expression of a muscle differentiation program modulated by MYOG, MEF2, and CDKN1A. Further, RAS/MEK-signaling modulates SNAI2 levels and binding to chromatin, suggesting that the differentiation blockade by oncogenic RAS is mediated in part by SNAI2. Thus, an interplay between SNAI2, MYOD, and RAS prevents myogenic differentiation and promotes tumorigenesis
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