Real-time graphic simulation for space telerobotics applications

Designing space-based telerobotic systems presents many problems unique to telerobotics and the space environment, but it also shares many common hardware and software design problems with Earth-based industrial robot applications. Such problems include manipulator design and placement, grapple-fixture design, and of course the development of effective and reliable control algorithms. Since first being applied to industrial robotics just a few years ago, interactive graphic simulation has proven to be a powerful tool for anticipating and solving problems in the design of Earth-based robotic systems and processes. Where similar problems are encountered in the design of space-based robotic mechanisms, the same graphic simulation tools may also be of assistance. The capabilities of PLACE, a commercially available interactive graphic system for the design and simulation of robotic systems and processes is described. A space-telerobotics application of the system is presented and discussed. Potential future enhancements are described

Survey on Additive Manufacturing, Cloud 3D Printing and Services

Cloud Manufacturing (CM) is the concept of using manufacturing resources in a service oriented way over the Internet. Recent developments in Additive Manufacturing (AM) are making it possible to utilise resources ad-hoc as replacement for traditional manufacturing resources in case of spontaneous problems in the established manufacturing processes. In order to be of use in these scenarios the AM resources must adhere to a strict principle of transparency and service composition in adherence to the Cloud Computing (CC) paradigm. With this review we provide an overview over CM, AM and relevant domains as well as present the historical development of scientific research in these fields, starting from 2002. Part of this work is also a meta-review on the domain to further detail its development and structure

Identifying characteristics of frailty in female mice using a phenotype assessment tool

Preclinical studies are important in identifying the underlying mechanisms contributing to frailty. Frailty studies have mainly focused on male rodents with little directed at female rodents. Therefore, the purposes of this study were to identify the onset and prevalence of frailty across the life span in female mice, and to determine if frailty predicts mortality. Female C57BL/6 (n = 27) mice starting at 17 months of age were assessed across the life span using a frailty phenotype, which included body weight, walking speed, strength, endurance, and physical activity. The onset of frailty occurred at approximately 17 months (1/27 mice), with the prevalence of frailty increasing thereafter. At 17 months, 11.1% of the mice were pre-frail and by 26 months peaked at 36.9%. The percentage of frail mice progressively increased up to 66.7% at 32 months. Non-frail mice lived to 29 months whereas frail/pre-frail mice lived only to 26 months (p = .04). In closing, using a mouse frailty phenotype, we are able to identify that the prevalence of frailty in female mice increases across the life span and accurately predicts mortality. Together, this frailty phenotype has the potential to yield information about the underlying mechanisms contributing to frailty.T32 AG029796 - NIA NIH HHSPublished versio

Sex-specific components of frailty in C57BL/6 mice.

Many age-related biochemical, physiological and behavioral changes are known to be sex-specific. However, how sex influences frailty status and mortality risk in frail rodents has yet to be established. The purpose of this study was therefore to characterize sex differences in frail mice across the lifespan. Male (n=29) and female (n=27) mice starting at 17 months of age were assessed using a frailty phenotype adjusted according to sex, which included body weight, walking speed, strength, endurance and physical activity. Regardless of sex, frail mice were phenotypically dysfunctional compared to age-matched non-frail mice, while non-frail females generally possessed a higher body fat percentage and were more physically active than non-frail males (p≤0.05). The prevalence of frailty was greater in female mice at 26 months of age (p=0.05), but if normalized to mean lifespan, no sex differences remained. No differences were detected in the rate of death or mean lifespan between frail male and female mice (p≥0.12). In closing, these data indicate that sexual differences exist in aging C57BL/6 mice and if the frailty criteria are adjusted according to sex, the prevalence of frailty increases across age with frail mice dying early in life, regardless of sex.T32 AG029796 - NIA NIH HHS; T32 AR007612 - NIAMS NIH HHSPublished versio

PERSPECTIVES IN METHODOLOGY IN BIOMECHANICS OF SPORT

1. OBJECTIVES OF BIOMECHANICS OF SPORT Biomechanics is mechanics applied to biological systems. It deals with the forces acting on and within these systems and the produced effects, the mechanical behaviour. In order to understand and to derive the laws and principles underlying the human movement the fundamental relations between structure and function be investigated. Biomechanics of sports is predominantly directed towards practical applications. The main objectives may be defined as follows: 1. improvement of performance and 2. prevention of excessive loads on the locomotor apparatus. These features are influenced by 1. sports techniques, 2. the physical condition of the athletes and 3. external conditions. 2. METHODOLOGY IN BIOMECHANICS OF SPORT. The scientific methodology playing a major role in biomechanics will be sketched and discussed briefly concerning both the state of the art and future perspectives. The discussion will follow according the subdivision: 1. the measuring techniques (instruments), 2. the modelling theory (theory), 3. the transfer procedures (application) The actual state of the art in these areas in general biomechanics or in related scientific fields is the result of a rapid technological development in the last decade. However the possibilities are not fully utilized in many practical applications in biomechanics of sport. Sometimes, for the sake of simplicity or because of other reasons, serious restrictions are stipulated on the system. model or instrumentation. These simplifications very openly yield results of limited value. The interpretation of results and the transfer into practice is the touchstone of the scientific work. The sometimes discussed "gap" between theory and practice indicates the need of improved procedures concerning the scientific approach and the communication between both sides. Now and then a pragmatic approach makes it necessary that biomechanics of sport has to be confined to a technical service just providing additional quantitative information in the process of teaching and coaching. 3. FUTURE DEVELOPMENTS In order to make biomechanics more effective in practical applications, the following developments have been started already or will happen in the near future: 1. an increased and improved exploitation of the theoretical tools and the measuring devices, 2. the use of expert systems to combine numerical biomechanical findings with empirical know ledge from different sources, 3. the common usage of computer power and simulation models for presentation of results, communication and computer aided learning, 4. the introduction of more complex strategies and tools like fuzzylogic sets and others

Downhill exercise alters immunoproteasome content in mouse skeletal muscle

Content of the immunoproteasome, the inducible form of the standard proteasome, increases in atrophic muscle suggesting it may be associated with skeletal muscle remodeling. However, it remains unknown if the immunoproteasome responds to stressful situations that do not promote large perturbations in skeletal muscle proteolysis. The purpose of this study was to determine how an acute bout of muscular stress influences immunoproteasome content. To accomplish this, wildtype (WT) and immunoproteasome knockout lmp7-/-/mecl1-/-(L7M1) mice were run downhill on a motorized treadmill. Soleus muscles were excised 1 and 3 days post-exercise and compared to unexercised muscle(control). Ex vivophysiology, histology and biochemical analyses were used to assess the effects of immunoproteasome knockout and unaccustomed exercise. Besides L7M1 muscle being LMP7/MECL1deficient, no other major biochemical, histological or functional differences were observed between the control muscles. In both strains, the downhill run shifted the force-frequency curve to the right and reduced twitch force, however did not alter tetanic force or inflammatory markers. In the days post-exercise, several of the proteasome 's catalytic subunits were upregulated. Specifically, WT muscle increased LMP7 while L7M1 muscle instead increased ≤ 5. These findings indicate that running mice downhill results in subtle contractile characteristics that correspond to skeletal muscle injury, yet does not appear to induce a significant inflammatory response. Interestingly, this minor stress activated the production of specific immunoproteasome subunits; that if knocked out, were replaced by components of the standard proteasome. These data suggest that the immunoproteasome may be involved in maintaining cellular homeostasis.This study was supported by the Elaine and Robert Larson Endowed Vision Research Chair (to DAF), the National Institutes of Health/National Institute of Aging (T32-AG29796 to CWB), an anonymous benefactor for Macular Degeneration Research, the Lindsay Family Foundation and an unrestricted grant from Research to Prevent Blindness to the Department of Ophthalmology and Visual Neurosciences. The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. (Elaine and Robert Larson Endowed Vision Research Chair; T32-AG29796 - National Institutes of Health/National Institute of Aging; Lindsay Family Foundation; Research to Prevent Blindness)Accepted manuscrip

Heat Shock Protein 70 Regulates Tumor Necrosis Factor-Alpha and Myogenin in Skeletal Muscle Following Chemical-Induced Injury

Skeletal muscle injury results in functional deficits that can take several weeks to fully recover. Ultimate recovery of function is dependent on the muscle’s ability to regenerate, a highly coordinated process that involves transient muscle inflammation and the replacement of damaged myofibers. Instrumental in the inflammatory response, is the pro-inflammatory cytokine TNF-α. Expression of TNF-α is thought to be regulated, in part, by the stress sensing 70 kDa heat shock protein (Hsp70). However, it remains unclear how Hsp70 alters TNF-α following injury, and if so, how these changes affect skeletal muscle repair. Therefore, we up-regulated Hsp70 expression using 17-allylamino-17-demethoxygeldanamycin (17-AAG) prior to and following BaCl2-induced injury, and assessed TNF-α and myogenin content. Regenerating fiber cross-sectional area (CSA) and in vivo isometric torque were also analyzed in the weeks following the injury. Treatment of 17-AAG resulted in a ~5 fold increase in Hsp70 of the uninjured muscle, but did not affect any other biochemical, morphological or functional variables compared to controls. In the days following the injury, TNF-α and myogenin were elevated and directly correlated. At these earlier time points (≤7 days), treatment of 17-AAG increased TNF-α above that of the injured controls and resulted in a sustained increase in myogenin. However, no differences were observed in regenerating fiber CSA or in vivo torque production between the groups. Together, these data suggest that Hsp70 induction increases TNF-α and myogenin content following BaCl2-induced injury, but does not appear to alter skeletal muscle regeneration or attenuate functional deficits in otherwise healthy young mice

SLIPPERY SLOPE ? ASSESSING THE ECONOMIC IMPACT OF THE 2002 WINTER OLYMPIC GAMES IN SALT LAKE CITY, UTAH

This paper provides an empirical examination of the 2002 Winter Olympic Games in Salt Lake City, Utah. Our analysis of taxable sales in the counties in which Olympic events took place finds that some sectors such as hotels and restaurants prospered while other retailers such as general merchandisers and department stores suffered. Overall the gains in the hospitality industry are lower than the losses experienced by other sectors in the economy. Given the experience of Utah, potential Olympic hosts should exercise caution before proceeding down the slippery slope of bidding for this event.OLYMPICS, IMPACT ANALYSIS, MEGA-EVENT

Denervation-induced activation of the standard proteasome and immunoproteasome

The standard 26S proteasome is responsible for the majority of myofibrillar protein degradation leading to muscle atrophy. The immunoproteasome is an inducible form of the proteasome. While its function has been linked to conditions of atrophy, its contribution to muscle proteolysis remains unclear. Therefore, the purpose of this study was to determine if the immunoproteasome plays a role in skeletal muscle atrophy induced by denervation. Adult male C57BL/6 wild type (WT) and immunoproteasome knockout lmp7-/-/mecl-1-/- (L7M1) mice underwent tibial nerve transection on the left hindlimb for either 7 or 14 days, while control mice did not undergo surgery. Proteasome activity (caspase-, chymotrypsin-, and trypsin- like), protein content of standard proteasome (β1, β5 and β2) and immunoproteasome (LMP2, LMP7 and MECL-1) catalytic subunits were determined in the gastrocnemius muscle. Denervation induced significant atrophy and was accompanied by increased activities and protein content of the catalytic subunits in both WT and L7M1 mice. Although denervation resulted in a similar degree of muscle atrophy between strains, the mice lacking two immunoproteasome subunits showed a differential response in the extent and duration of proteasome features, including activities and content of the β1, β5 and LMP2 catalytic subunits. The results indicate that immunoproteasome deficiency alters the proteasome's composition and activities. However, the immunoproteasome does not appear to be essential for muscle atrophy induced by denervation.T32 AG029796 - NIA NIH HH

On the predictive power of Local Scale Invariance

Local Scale Invariance (LSI) is a theory for anisotropic critical phenomena designed in the spirit of conformal invariance. For a given representation of its generators it makes non-trivial predictions about the form of universal scaling functions. In the past decade several representations have been identified and the corresponding predictions were confirmed for various anisotropic critical systems. Such tests are usually based on a comparison of two-point quantities such as autocorrelation and response functions. The present work highlights a potential problem of the theory in the sense that it may predict any type of two-point function. More specifically, it is argued that for a given two-point correlator it is possible to construct a representation of the generators which exactly reproduces this particular correlator. This observation calls for a critical examination of the predictive content of the theory.Comment: 17 pages, 2 eps figure