477 research outputs found
Metal-to-insulator transition and magnetic ordering in CaRu_{1-x}Cu_xO_3
CaRuO_3 is perovskite with an orthorhombic distortion and is believed to be
close to magnetic ordering. Magnetic studies of single crystal and
polycrystalline CaRu_{1-x}Cu_xO_3 (0\le x \le 15 at.%Cu) reveal that
spin-glass-like transition develops for x\le 7 at.%Cu and obtained value for
effective magnetic moment p_{eff}=3.55 mu_B for x=5 at.% Cu, single crystal,
indicates presence of Ru^{5+}. At higher Cu concentrations more complex
magnetic behaviors are observed. Electrical resistivity measured on
polycrystalline samples shows metal-to-insulator transition (MIT) at 51 K for
only 2 at.% Cu. Charge compensation, which is assumed to be present upon
Cu^{2+/3+} substitution, induces appearance of Ru^{5+} and/or creation of
oxygen vacancies in crystal structure. Since the observed changes in physical
properties are completely attributable to the charge compensation, they cannot
be related to behaviors of pure compound where no such mechanism is present.
This study provides the criterion for "good" chemical probes for studying
Ru-based perovskites.Comment: 12 pages, 7 figure
A Transport and Microwave Study of Superconducting and Magnetic RuSr2EuCu2O8
We have performed susceptibility, thermopower, dc resistance and microwave
measurements on RuSr2EuCu2O8. This compound has recently been shown to display
the coexistence of both superconducting and magnetic order. We find clear
evidence of changes in the dc and microwave resistance near the magnetic
ordering temperature (132 K). The intergranular effects were separated from the
intragranular effects by performing microwave measurements on a sintered
ceramic sample as well as on a powder sample dispersed in an epoxy resin. We
show that the data can be interpreted in terms of the normal-state resistivity
being dominated by the CuO2 layers with exchange coupling to the Ru moments in
the RuO2 layers. Furthermore, most of the normal-state semiconductor-like
upturn in the microwave resistance is found to arise from intergranular
transport. The data in the superconducting state can be consistently
interpreted in terms of intergranular weak-links and an intragranular
spontaneous vortex phase due to the ferromagnetic component of the
magnetization arising from the RuO2 planes.Comment: 20 pages including 6 figures in pdf format. To be published in Phys.
Rev.
Dynamical mean-field theory of the Anderson-Hubbard model with local and nonlocal disorder in tensor formulation
To explore correlated electrons in the presence of local and non-local
disorder, the Blackman-Esterling-Berk method for averaging over off-diagonal
disorder is implemented into dynamical mean-field theory using tensor notation.
The impurity model combining disorder and correlations is solved using the
recently developed fork tensor-product state solver, which allows one to
calculate the single particle spectral functions on the real-frequency axis. In
the absence of off-diagonal hopping, we establish exact bounds of the spectral
function of the non-interacting Bethe lattice with coordination number . In
the presence of interaction, the Mott insulating paramagnetic phase of the
one-band Hubbard model is computed at zero temperature in alloys with site- and
off-diagonal disorder. When the Hubbard parameter is increased, transitions
from an alloy band-insulator through a correlated metal into a Mott insulating
phase are found to take place.Comment: 15 pages, 5 figures. See ancillary folder for numerical data and
computational detail
Decoupled CuO_2 and RuO_2 layers in superconducting and magnetically ordered RuSr_2GdCu_2O_8
Comprehensive measurements of dc and ac susceptibility, dc resistance,
magnetoresistance, Hall resistivity, and microwave absorption and dispersion in
fields up to 8 T have been carried out on RuSr_2GdCu_2O_8 with the aim to
establish the properties of RuO_2 and CuO_2 planes. At ~130 K, where the
magnetic order develops in the RuO_2 planes, one observes a change in the slope
of dc resistance, change in the sign of magnetoresistance, and the appearance
of an extraordinary Hall effect. These features indicate that the RuO_2 planes
are conducting. A detailed analysis of the ac susceptibility and microwave data
on both, ceramic and powder samples show that the penetration depth remains
frequency dependent and larger than the London penetration depth even at low
temperatures. We conclude that the conductivity in the RuO_2 planes remains
normal even when superconducting order is developed in the CuO_2 planes below
\~45 K. Thus, experimental evidence is provided in support of theoretical
models which base the coexistence of superconductivity and magnetic order on
decoupled CuO_2 and RuO_2 planes.Comment: 11 pages, 11 figures, submitted to PR
The Superconductivity, Intragrain Penetration Depth and Meissner Effect of RuSr2(Gd,Ce)2Cu2O10+delta
The hole concentration (p)(delta), the transition temperature Tc, the
intragrain penetration depth lambda, and the Meissner effect were measured for
annealed RuSr2(Gd,Ce)2Cu2O10+delta samples. The intragrain superconducting
transition temperature Tc} varied from 17 to 40 K while the p changed by only
0.03 holes/CuO2. The intragrain superfluid-density 1/lambda^2 and the
diamagnetic drop of the field-cooled magnetization across Tc (the Meissner
effect), however, increased more than 10 times. All of these findings are in
disagreement with both the Tc vs. p and the Tc vs. 1/lambda^2 correlations
proposed for homogeneous cuprates, but are in line with a possible
phase-separation and the granularity associated with it.Comment: 7 pages, 6 figures, accepted for publication in Phys. Rev. B (May 2,
2002
Study of the crystal structure, superconducting and magnetic properties of Ru1-xFexSr2GdCu2O8
Samples of the Ru1-xFexSr2GdCu2O8 system with x = 0, 0.025, 0.05, 0.075, 0.1
and 0.2, were prepared and their structural, superconducting and magnetic
properties were studied. Rietveld refinement of the X-ray diffraction patterns
show that the Fe substitution occurs in both Ru and Cu sites. An increase of Fe
concentration produces no significant changes in the bond angle Ru-O(3)-Ru,
which is a measure of the rotation of the RuO6 octahedra around the c-axis, and
also in the bond angle Ru-O(1)-Cu, which is a measure of the canting of the
RuO6 octahedra. On the other hand, the bond angle Cu-O(2)-Cu, which is a
measure of the buckling of the CuO2 layer, has a slight tendency to decrease
with the increase of the Fe content. We found thet both ferromagnetic and
superconducting transition temperatures are reduced with the increase of Fe
concentration. Analisys related to the decay of the superconducting and
ferromagnetic states is presented.Comment: 9 pages, 7 figure
GM-CSF Signalling Boosts Dramatically IL-1Production
GM-CSF is mostly known for its capacity to promote bone marrow progenitor differentiation, to mobilize and mature myeloid cells as well as to enhance host immune responses. However the molecular actions of GM-CSF are still poorly characterized. Here we describe a new surprising facet of this “old” growth factor as a key regulator involved in IL-1βsecretion. We found that IL-1β release, a pivotal component of the triggered innate system, is heavily dependent on the signaling induced by GM-CSF in such an extent that in its absence IL-1β is only weakly secreted. GM-CSF synergizes with LPS for IL-1β secretion mainly at the level of pro-IL-1β production via strengthening the NF-κB signaling. In addition, we show that expression of Rab39a, a GTPase required for caspase-1 dependent IL-1β secretion is greatly augmented by LPS and GM-CSF co-stimulation suggesting a potential GM-CSF contribution in enhancing IL-1β exocytosis. The role of GM-CSF in regulating IL-1β secretion is extended also in vivo, since GM-CSF R−/− mice are more resistant to LPS-mediated septic shock. These results identify GM-CSF as a key regulator of IL-1β production and indicate GM-CSF as a previously underestimated target for therapeutic intervention
Sertoli cells have a functional NALP3 inflammasome that can modulate autophagy and cytokine production
Sertoli cells, can function as non-professional tolerogenic antigen-presenting cells, and sustain the blood-testis barrier formed by their tight junctions. The NOD-like receptor family members and the NALP3 inflammasome play a key role in pro-inflammatory innate immunity signalling pathways. Limited data exist on NOD1 and NOD2 expression in human and mouse Sertoli cells. Currently, there is no data on inflammasome expression or function in Sertoli cells. We found that in primary pre-pubertal Sertoli cells and in adult Sertoli line, TLR4\NOD1 and NOD2 crosstalk converged in NF?B activation and elicited a NALP3 activation, leading to de novo synthesis and inflammasome priming. This led to caspase-1 activation and IL-1? secretion. We demonstrated this process was controlled by mechanisms linked to autophagy. NOD1 promoted pro-IL-1? restriction and autophagosome maturation arrest, while NOD2 promoted caspase-1 activation, IL-1? secretion and autophagy maturation. NALP3 modulated NOD1 and pro-IL-1? expression, while NOD2 inversely promoted IL-1?. This study is proof of concept that Sertoli cells, upon specific stimulation, could participate in male infertility pathogenesis via inflammatory cytokine induction
Is the inflammasome a potential therapeutic target in renal disease?
The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine production in response to infection and tissue injury. Pattern recognition receptors that are either membrane bound or cytoplasmic trigger inflammasome assembly. These receptors sense danger signals including damage-associated molecular patterns and pathogen-associated molecular patterns (DAMPS and PAMPS respectively). The best-characterized inflammasome is the NLRP3 inflammasome. On assembly of the NLRP3 inflammasome, post-translational processing and secretion of pro-inflammatory cytokines IL-1β and IL-18 occurs; in addition, cell death may be mediated via caspase-1. Intrinsic renal cells express components of the inflammasome pathway. This is most prominent in tubular epithelial cells and, to a lesser degree, in glomeruli. Several primary renal diseases and systemic diseases affecting the kidney are associated with NLRP3 inflammasome/IL-1β/IL-18 axis activation. Most of the disorders studied have been acute inflammatory diseases. The disease spectrum includes ureteric obstruction, ischaemia reperfusion injury, glomerulonephritis, sepsis, hypoxia, glycerol-induced renal failure, and crystal nephropathy. In addition to mediating renal disease, the IL-1/ IL-18 axis may also be responsible for development of CKD itself and its related complications, including vascular calcification and sepsis. Experimental models using genetic deletions and/or receptor antagonists/antiserum against the NLRP3 inflammasome pathway have shown decreased severity of disease. As such, the inflammasome is an attractive potential therapeutic target in a variety of renal diseases
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