2 research outputs found

    Me3Al-mediated domino nucleophilic addition/intramolecular cyclisation of 2-(2-oxo-2-phenylethyl)benzonitriles with amines; a convenient approach for the synthesis of substituted 1-aminoisoquinolines

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    A simple and efficient protocol for the construction of 1-aminoisoquinolines was achieved by treating 2-(2-oxo-2- phenylethyl)benzonitriles with amines in the presence of Me 3 Al. The reaction proceeds via a domino nucleophilic addition with subsequent intramolecular cyclisation. This method provides a wide variety of substituted 1-aminoisoquinolines with good func- tional group tolerance. Furthermore, the synthetic utility of this protocol was demonstrated in the successful synthesis of the anti- tumor agent CWJ-a-5 in gram scale

    Phytochemical Analysis Of Avicennia Officinalis Of Krishna Estuary

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    Phytochemical investigation on the aerial roots of Avicennia officinalis of Krishna estuary, India resulted in the isolation ofthree pentacyclic triterpenoids, betulin aldehyde (1), betulinic acid ( 2) and betulin ( 3). These are characterized byphysical and spectral data. All are known compounds but we are reporting first time from the Krishna estuary species.Compound ( 2) was also possess Cytotoxicity
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