Me3Al-mediated domino nucleophilic addition/intramolecular cyclisation of 2-(2-oxo-2-phenylethyl)benzonitriles with amines; a convenient approach for the synthesis of substituted 1-aminoisoquinolines

A simple and efficient protocol for the construction of 1-aminoisoquinolines was achieved by treating 2-(2-oxo-2- phenylethyl)benzonitriles with amines in the presence of Me 3 Al. The reaction proceeds via a domino nucleophilic addition with subsequent intramolecular cyclisation. This method provides a wide variety of substituted 1-aminoisoquinolines with good func- tional group tolerance. Furthermore, the synthetic utility of this protocol was demonstrated in the successful synthesis of the anti- tumor agent CWJ-a-5 in gram scale

Phytochemical Analysis Of Avicennia Officinalis Of Krishna Estuary

Phytochemical investigation on the aerial roots of Avicennia officinalis of Krishna estuary, India resulted in the isolation ofthree pentacyclic triterpenoids, betulin aldehyde (1), betulinic acid ( 2) and betulin ( 3). These are characterized byphysical and spectral data. All are known compounds but we are reporting first time from the Krishna estuary species.Compound ( 2) was also possess Cytotoxicity