"Gait Analysis in Patients after Van Nes Rotationplasty"

Gait was analyzed through kinetic, kinematic, and temporal-distance parameters assessment to evaluate the functional performance of ten children treated by the classical Van Nes rotationplasty (VNR). Van Nes rotationplasty is a surgical procedure, which permits the conversion of the ankle joint into a "pseudo-knee" joint. The data were compared with measurements of a normal population of ten healthy subjects. Significant differences with respect to the normal were found in stride duration, stride length, cadence, velocity, and stance-swing ratio, and in ground-reaction forces parameters, which define the propulsive phase in the prosthetic side and the acceptance phase in the sound side. There were differences in some kinematic parameters as well. Van Nes rotationplasty is acceptable from a biomechanical-functional point of view, particularly with respect to the active control of the pseudo-knee, which allows a smooth and coordinate gait pattern

Non-metastatic Ewing’s sarcoma: results in 98 patients treated with neoadjuvant chemotherapy.

From June 1983 to December 1987, 98 patients with non-metastatic Ewing's sarcoma of bone were treated by a protocol of neoadjuvant chemotherapy consisting of two months of preoperative chemotherapy with vincristine, adriamycin, and cyclophosphamide followed by local treatment and one year of chemotherapy aimed at preventing recurrence using the same drugs plus dactinomycin. Local treatment consisted of surgery in 39 cases (40%), radiation in 34 (34%), and both surgery and radiation in 25 (26%). After an average follow-up of five years, 51 patients (52%) had remained continuously disease-free (CDF), 46 had developed metastasis, of which 20 with local recurrence, and one had developed a radioinduced sarcoma. The site of the tumor (61% of patients with Ewing's sarcoma of the extremities were CDF vs. 35% with tumor of the pelvis) and the kind of local treatment (61% of patients who underwent surgery with or without radiation therapy were CDF vs. 35% of patients treated with radiation therapy alone) were important prognostic factors. These results are similar to those obtained in 59 patients treated from 1979 to 1982 (average follow-up, 10 years) using the same drugs administered according to adjuvant chemotherapy procedure as well as those reported in the only other large study on this subject in the literature (the multi-institution German study CESS-81). The authors conclude that even though neoadjuvant chemotherapy makes surgery possible and easier in Ewing's sarcoma, it does not significantly increase survival when compared to traditional adjuvant treatment

"Sarcoma di Ewing non Metastatico: Risultati in 98 Pazienti Trattati con Chemioterapia Neoadjuvante"

"Sarcoma di Ewing non Metastatico: Risultati in 98 Pazienti Trattati con Chemioterapia Neoadjuvante

Il Perugino nella Marca 1488-1497

Viene illustrata la situazione culturale marchigiana negli anni nei quali Pietro Vannucci vi realizza o spedisce sue opere: da Urbino per i Montefeltro, a Fano per i francescani, a Fabriano per gli agostiniani. Quando si trova nel cantiere di Fano (città nella quale ha realizzato anche una pala ora conservata a Senigallia) viene a contatto con Giovanni Santi, padre di Raffaello particolarmente attivo con la sua bottega in Urbino

Acquisto di opere di Giovanni Santi, tra operazione critica e interesse di mercato

Indagine sulle vendite di opere già presenti nelle Marche con particolare interesse a dipinti di Giovanni Santi che desta interesse a seguito della pubblicazione di volumi (Pungileoni, Passavanti, Layard) che lo riguardano alla ricerca delle origini dell'arte del figlio Raffaello. Esempi tratti da raccolte inglesi, tedesche e austriache