A Recognition-Based Alternative to Discrimination-Based Multi-layer Perceptrons

Though impressive classification accuracy is often obtained via discrimination-based learning techniques such as Multi-Layer Perceptrons (DMLP), these techniques often assume that the underlying training sets are optimally balanced (in terms of the number of positive and negative examples). Unfortunately, this is not always the case. In this paper, we look at a recognitionbased approach whose accuracy in such environments is superior to that obtained via more conventional mechanisms. At the heart of the new technique is a modified auto-encoder that allows for the incorporation of a recognition component into the conventional MLP mechanism. In short, rather than being associated with an output value of "1", positive examples are fully reconstructed at the network output layer while negative examples, rather than being associated with an output value of "0", have their inverse derived at the output layer. The result is an auto-encoder able to recognize positive examples while discriminating against negative ones by virtue of the fact that negative cases generate larger reconstruction errors. A simple technique is employed to exaggerate the impact of training with these negative examples so that reconstruction errors can be more reliably established. Preliminary testing on both seismic and sonar data sets has demonstrated that the new method produces lower error rates than standard connectionist systems in imbalanced settings. Our approach thus suggests a simple and more robust alternative to commonly used classification mechanisms

Secondary Endoleak Management Following TEVAR and EVAR.

Endovascular abdominal and thoracic aortic aneurysm repair and are widely used to treat increasingly complex aneurysms. Secondary endoleaks, defined as those detected more than 30 days after the procedure and after previous negative imaging, remain a challenge for aortic specialists, conferring a need for long-term surveillance and reintervention. Endoleaks are classified on the basis of their anatomic site and aetiology. Type 1 and type 2 endoleaks (EL1 and EL2) are the most common endoleaks necessitating intervention. The management of these requires an understanding of their mechanics, and the risk of sac enlargement and rupture due to increased sac pressure. Endovascular techniques are the main treatment approach to manage secondary endoleaks. However, surgery should be considered where endovascular treatments fail to arrest aneurysm growth. This chapter reviews the aetiology, significance, management strategy and techniques for different endoleak types

Cardiac Sarcomere Signaling in Health and Disease

The cardiac sarcomere is a triumph of biological evolution wherein myriad contractile and regulatory proteins assemble into a quasi-crystalline lattice to serve as the central point upon which cardiac muscle contraction occurs. This review focuses on the many signaling components and mechanisms of regulation that impact cardiac sarcomere function. We highlight the roles of the thick and thin filament, both as necessary structural and regulatory building blocks of the sarcomere as well as targets of functionally impactful modifications. Currently, a new focus emerging in the field is inter-myofilament signaling, and we discuss here the important mediators of this mechanism, including myosin-binding protein C and titin. As the understanding of sarcomere signaling advances, so do the methods with which it is studied. This is reviewed here through discussion of recent live muscle systems in which the sarcomere can be studied under intact, physiologically relevant conditions

Round cell sarcoma of the colon with CIC rearrangement

Abstract Background The CIC-rearranged sarcoma is a very rare highly aggressive malignant soft tissue group of tumors. It has recently been described as highly aggressive soft tissue tumors of children and young adults sharing similar morphological features with the Ewing sarcoma. The digestive localization is exceptional. Case presentation A 14-year-old male presented with a history of abdominal pain for 1 year, which increased in intensity over the last 2 months. Imaging findings showed a large heterogeneous mesenteric mass on the left flank of the abdomen. Exploratory laparotomy was performed and revealed a large cystic hypervascularized mass depending on the transverse colon and mesocolon. A wide excision of the lesion was performed with segmental colectomy. No postoperative complications were noted. The microscopic examination revealed a vaguely nodular growth of undifferentiated small round cells, arranged in solid sheets separated by thin fibrous septa with a scarce stroma. After an uncomplicated post-operative course, the patient was referred for chemotherapy. The patient died 2 months later with a peritoneal and pleural progression. Conclusions The CIC-rearranged sarcoma is an aggressive tumor. There is no standard therapy for this rare disease. Their treatment includes surgery and chemotherapy. Resistance to chemotherapy is common. Further publications and studies will help to determine a standard therapy for this rare disease