Awareness of cognitive decline trajectories in asymptomatic individuals at risk for AD

Background: Lack of awareness of cognitive decline (ACD) is common in late-stage Alzheimer’s disease (AD). Recent studies showed that ACD can also be reduced in the early stages. Methods: We described different trends of evolution of ACD over 3 years in a cohort of memory-complainers and their association to amyloid burden and brain metabolism. We studied the impact of ACD at baseline on cognitive scores’ evolution and the association between longitudinal changes in ACD and in cognitive score. Results: 76.8% of subjects constantly had an accurate ACD (reference class). 18.95% showed a steadily heightened ACD and were comparable to those with accurate ACD in terms of demographic characteristics and AD biomarkers. 4.25% constantly showed low ACD, had significantly higher amyloid burden than the reference class, and were mostly men. We found no overall effect of baseline ACD on cognitive scores’ evolution and no association between longitudinal changes in ACD and in cognitive scores. Conclusions: ACD begins to decrease during the preclinical phase in a group of individuals, who are of great interest and need to be further characterized. Trial registration: The present study was conducted as part of the INSIGHT-PreAD study. The identification number of INSIGHT-PreAD study (ID-RCB) is 2012-A01731-42

Low Cognitive Awareness, but Not Complaint, is a Good Marker of Preclinical Alzheimer's Disease

Subjective cognitive decline (SCD) may result from many conditions, including Alzheimer's disease (AD)

ECOCAPTURE Dataset - Behavioral coding from video - 20 bvFTD and 18 HC - 21.03.2022

This dataset is obtained by behavioral coding from 7-minute video footage for each individual in a group of 20 patients with bvFTD and a group of 18 healthy controls.Behavioral coding data were collected through the continuous sampling method (all occurrences of behaviors and their duration were recorded) using NOLDUS The Observer XT (Version 14.0) [1].Behavioral coding was conducted based on two ethograms (the ECOCAPTURE apathy ethogram, the ECOCAPTURE disinhibition ethogram) [2].This dataset provides two files : 1) the events log; 2) a table containing for each individual: the demographic characteristics, the neuropsychological features, the ECOCAPTURE metrics (number of occurrences and/or duration of behavior).V3 - Adding MATTIS score in the database[1] Behavioral coding - Event logging software | The Observer XT. Accessed April 10, 2022. https://www.noldus.com/observer-xt[2] Batrancourt, Bénédicte; Migliaccio, Raffaella (Lara); Tanguy, Delphine; Sezer, Idil; Godefroy, Valerie; Bouzigues, Arabella (2022), “The ECOCAPTURE ethograms: apathy ethogram and disinhibition ethogram”, Mendeley Data, V2, doi: 10.17632/mv8hndcd95.2THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

The ECOCAPTURE ethograms: apathy ethogram and disinhibition ethogram

This dataset provides two ethograms: the ECOCAPTURE apathy ethogram and the ECOCAPTURE disinhibition ethogram. The ECOCAPTURE apathy ethogram includes 13 behaviors and 31 modifiers divided in two behavioral categories: motor patterns, activity states. The ECOCAPTURE disinhibition ethogram includes 16 behaviors divided in three disinhibition categories: compulsivity, impulsivity, social disinhibition. The ECOCAPTURE protocol [1,2] developed at ICM [3], was designed to assess neuropsychiatric symptoms, such as apathy [4] and disinhibition [5], in natural settings and under a controlled scenario. The ECOCAPTURE scenario mimics a naturalistic situation (i.e., waiting comfortably in a waiting room). The experiments took place on the ICM’s core facility (PRISME) [6] dedicated to the functional exploration of human behavior.The PRISME platform was equipped with a six-ceiling camera system (not hidden) covering the entire waiting room. During the experiment, individuals’ behavior was video-recorded. The subjects were informed at the time of initial consent that their behavior would be tracked and recorded by video cameras located in the room. [1] Institut National de la Santé Et de la Recherche Médicale, France. Quantitative Evaluation of Apathy Close to Real Life Situation by Means of a Multimodal Sensor System Integrated in Healthy Subjects and Patients With Frontotemporal Dementia. Pilot Phase. clinicaltrials.gov; 2017. https://clinicaltrials.gov/ct2/show/NCT02496312 [2] Institut National de la Santé Et de la Recherche Médicale, France. Assessment of Apathy in a Real-Life Situation, With a Video and Sensors-Based System in Healthy Subject and Patient With Cerebral Disease. clinicaltrials.gov; 2019. https://clinicaltrials.gov/ct2/show/NCT03272230 [3] Paris Brain Institute (ICM). Institut du Cerveau. https://institutducerveau-icm.org/en/ [4] Batrancourt B, Lecouturier K, Ferrand-Verdejo J, et al. Exploration Deficits Under Ecological Conditions as a Marker of Apathy in Frontotemporal Dementia. Front Neurol. 2019;10:941. doi:10.3389/fneur.2019.00941[5] Godefroy V, Tanguy D, Bouzigues A, et al. Frontotemporal dementia subtypes based on behavioral inhibition deficits. Alzheimers Dement Diagn Assess Dis Monit. 2021;13(1):e12178. doi:10.1002/dad2.12178[6] PRISME : human behavior exploration core facility. Institut du Cerveau. https://institutducerveau-icm.org/fr/prisme-human-behavior-exploration-core-facility/THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

ECOCAPTURE Dataset - Behavioral coding from video - 20 bvFTD and 18 HC - 21.03.2022

This dataset is obtained by behavioral coding from 7-minute video footage for each individual in a group of 20 patients with bvFTD and a group of 18 healthy controls.Behavioral coding data were collected through the continuous sampling method (all occurrences of behaviors and their duration were recorded) using NOLDUS The Observer XT (Version 14.0) [1].Behavioral coding was conducted based on two ethograms (the ECOCAPTURE apathy ethogram, the ECOCAPTURE disinhibition ethogram) [2].This dataset provides two files : 1) the events log; 2) a table containing for each individual: the demographic characteristics, the neuropsychological features, the ECOCAPTURE metrics (number of occurrences and/or duration of behavior).V3 - Adding MATTIS score in the databaseV4 - Adding MATTIS memory (MATTIS_MEM) score in the database[1] Behavioral coding - Event logging software | The Observer XT. Accessed April 10, 2022. https://www.noldus.com/observer-xt[2] Batrancourt, Bénédicte; Migliaccio, Raffaella (Lara); Tanguy, Delphine; Sezer, Idil; Godefroy, Valerie; Bouzigues, Arabella (2022), “The ECOCAPTURE ethograms: apathy ethogram and disinhibition ethogram”, Mendeley Data, V2, doi: 10.17632/mv8hndcd95.2THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

ECOCAPTURE Dataset - Behavioral coding from video - 17 bvFTD and 18 HC - 28.04.2022

This dataset consists of neuropsychological data and ECOCAPTURE behavioral metrics. Behavioral metrics were obtained by behavioral coding from 45-minute video footage for each individual in a group of 17 patients with bvFTD and a group of 18 healthy controls. These behavioral coding data were collected through the continuous sampling method (all occurrences of behaviors were recorded) using NOLDUS The Observer XT (Version 14.0) [1], and based on the ECOCAPTURE disinhibition ethogram [2].[1] Behavioral coding - Event logging software | The Observer XT. Accessed April 10, 2022. https://www.noldus.com/observer-xt[2] Batrancourt, Bénédicte; Migliaccio, Raffaella (Lara); Tanguy, Delphine; Sezer, Idil; Godefroy, Valerie; Bouzigues, Arabella (2022), “The ECOCAPTURE ethograms: apathy ethogram and disinhibition ethogram”, Mendeley Data, V2, doi: 10.17632/mv8hndcd95.2THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

ECOCAPTURE Dataset - Behavioral coding from video - 20 bvFTD and 18 HC - 21.03.2022

This dataset is obtained by behavioral coding from 7-minute video footage for each individual in a group of 20 patients with bvFTD and a group of 18 healthy controls.Behavioral coding data were collected through the continuous sampling method (all occurrences of behaviors and their duration were recorded) using NOLDUS The Observer XT (Version 14.0) [1].Behavioral coding was conducted based on two ethograms (the ECOCAPTURE apathy ethogram, the ECOCAPTURE disinhibition ethogram) [2].This dataset provides two files : 1) the events log; 2) a table containing for each individual: the demographic characteristics, the neuropsychological features, the ECOCAPTURE metrics (number of occurrences and/or duration of behavior).[1] Behavioral coding - Event logging software | The Observer XT. Accessed April 10, 2022. https://www.noldus.com/observer-xt[2] Batrancourt, Bénédicte; Migliaccio, Raffaella (Lara); Tanguy, Delphine; Sezer, Idil; Godefroy, Valerie; Bouzigues, Arabella (2022), “The ECOCAPTURE ethograms: apathy ethogram and disinhibition ethogram”, Mendeley Data, V1, doi: 10.17632/mv8hndcd95.1THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

ECOCAPTURE Dataset - Behavioral coding from video - 20 bvFTD and 18 HC - 21.03.2022

This dataset is obtained by behavioral coding from 7-minute video footage for each individual in a group of 20 patients with bvFTD and a group of 18 healthy controls.Behavioral coding data were collected through the continuous sampling method (all occurrences of behaviors and their duration were recorded) using NOLDUS The Observer XT (Version 14.0) [1].Behavioral coding was conducted based on two ethograms (the ECOCAPTURE apathy ethogram, the ECOCAPTURE disinhibition ethogram) [2].This dataset provides two files : 1) the events log; 2) a table containing for each individual: the demographic characteristics, the neuropsychological features, the ECOCAPTURE metrics (number of occurrences and/or duration of behavior).[1] Behavioral coding - Event logging software | The Observer XT. Accessed April 10, 2022. https://www.noldus.com/observer-xt[2] Batrancourt, Bénédicte; Migliaccio, Raffaella (Lara); Tanguy, Delphine; Sezer, Idil; Godefroy, Valerie; Bouzigues, Arabella (2022), “The ECOCAPTURE ethograms: apathy ethogram and disinhibition ethogram”, Mendeley Data, V2, doi: 10.17632/mv8hndcd95.2THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

ECOCAPTURE Dataset - Behavioral coding from video - 23 bvFTD and 24 HC - 28.11.2022

This dataset consists of neuropsychological data and ECOCAPTURE behavioral metrics (two Excel files) as well as the R code in order to reproduce the results.The behavior of 23 bvFTD patients and 24 HCs was observed, and the behavioral data were collected based on the ECOCAPTURE Disinhibition ethogram and apathy ethogram, throughout the 45-minute ECOCAPTURE protocol, and three sample sessions: 7-minute FP, 7-minute GP, 3-minute GP. Behavioral metrics were obtained by behavioral coding from 45-minute video footage for each individual.These behavioral coding data were collected through the continuous sampling method (all occurrences of behaviors were recorded) using NOLDUS The Observer XT (Version 14.0) [1], and based on the ECOCAPTURE disinhibition ethogram as well as the ECOCAPTURE apathy ethogram [2].[1] Behavioral coding - Event logging software | The Observer XT. Accessed April 10, 2022. https://www.noldus.com/observer-xt[2] Batrancourt, Bénédicte; Migliaccio, Raffaella (Lara); Tanguy, Delphine; Sezer, Idil; Godefroy, Valerie; Bouzigues, Arabella (2022), “The ECOCAPTURE ethograms: apathy ethogram and disinhibition ethogram”, Mendeley Data, V2, doi: 10.17632/mv8hndcd95.2THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV