D-Terms, Unification, and the Higgs Mass

We study gauge extensions of the MSSM that contain non-decoupling D-terms, which contribute to the Higgs boson mass. These models naturally maintain gauge coupling unification and raise the Higgs mass without fine-tuning. Unification constrains the structure of the gauge extensions, limiting the Higgs mass in these models to roughly less than 150 GeV. The D-terms contribute to the Higgs mass only if the extended gauge symmetry is broken at energies of a few TeV, leading to new heavy gauge bosons in this mass range.Comment: 30+1 pages, 7 figure

Utilisation and outcomes of cervical cancer prevention services among HIV-infected women in Cape Town

Objective. An audit of outcomes of cervical cancer screeningand prevention services for HIV-positive women in Cape Town, South Africa.Design. Retrospective review of clinic registers, patient records and pathology databases at three HIV primary health clinics and a tertiary colposcopy referral centre. Subjects. Women recently diagnosed with HIV at three primary health clinics between 2006 and 2008 (N=2 240); new patients seen for colposcopy at a tertiary referral centrebetween 2006 and 2009 (N=2 031).Outcome measures. The proportion of women undergoing cervical cancer screening after HIV diagnosis at primary health clinics, demographic characteristics of women referred for colposcopy at a tertiary centre, and outcomes of therapy for precancerous lesions of the cervix.Results. The proportion of women undergoing at least one Pap smear at HIV primary health clinics after HIV diagnosis was low (13.1%). Women referred for colposcopy tended to be HIV-positive and over the age of 30 years, and in most (70.2%) cytological examination revealed high-grade cervical dysplasia. HIV-positive women treated with excision for precancerous lesions of the cervix were significantly morelikely than their HIV-negative counterparts to undergo incomplete excision, experience persistent cervical disease after treatment, and be lost to follow-up.Conclusion. Cervical cancer screening efforts must be scaled up for women with HIV. Treatment and surveillance guidelines for cervical intraepithelial neoplasia in HIV-positive women may need to be revised and new interventions developed to reduce incomplete treatment and patient default

A Determination of the Hubble Constant from Cepheid Distances and a Model of the Local Peculiar Velocity Field

We present a measurement of the Hubble Constant based on Cepheid distances to 27 galaxies within 20 Mpc. We take the Cepheid data from published measurements by the Hubble Telescope Key Project on the Distance Scale (H0KP). We calibrate the Cepheid Period-Luminosity (PL) relation with data from over 700 Cepheids in the LMC obtained by the OGLE collaboration; we assume an LMC distance modulus of 18.50 mag (d=50.1 kpc). Using this PL calibration we obtain new distances to the H0KP galaxies. We correct the redshifts of these galaxies for peculiar velocities using two distinct velocity field models: the phenomenological model of Tonry et al. and a model based on the IRAS density field and linear gravitational instability theory. We combine the Cepheid distances with the corrected redshifts for the 27 galaxies to derive H_0, the Hubble constant. The results are H_0 = 85 +/- 5 km/s/Mpc (random error) at 95% confidence when the IRAS model is used, and 92 +/- 5 km/s/Mpc when the phenomenological model is used. The IRAS model is a better fit to the data and the Hubble constant it returns is more reliable. Systematic error stems mainly from LMC distance uncertainty which is not directly addressed by this paper. Our value of H_0 is significantly larger than that quoted by the H0KP, H_0 = 71 +/- 6 km/s/Mpc. Cepheid recalibration explains ~30% of this difference, velocity field analysis accounts for ~70%. We discuss in detail possible reasons for this discrepancy and future study needed to resolve it.Comment: 33 pages, 8 embedded figures. New table, 5 new references, text revision

Z-prime Gauge Bosons at the Tevatron

We study the discovery potential of the Tevatron for a Z-prime gauge boson. We introduce a parametrization of the Z-prime signal which provides a convenient bridge between collider searches and specific Z-prime models. The cross section for p pbar -> Z-prime X -> l^+ l^- X depends primarily on the Z-prime mass and the Z-prime decay branching fraction into leptons times the average square coupling to up and down quarks. If the quark and lepton masses are generated as in the standard model, then the Z-prime bosons accessible at the Tevatron must couple to fermions proportionally to a linear combination of baryon and lepton numbers in order to avoid the limits on Z--Z-prime mixing. More generally, we present several families of U(1) extensions of the standard model that include as special cases many of the Z-prime models discussed in the literature. Typically, the CDF and D0 experiments are expected to probe Z-prime-fermion couplings down to 0.1 for Z-prime masses in the 500--800 GeV range, which in various models would substantially improve the limits set by the LEP experiments.Comment: 34 pages, 13 figure

The number of privately treated tuberculosis cases in India: an estimation from drug sales data

Background Understanding the amount of tuberculosis managed by the private sector in India is crucial to understanding the true burden of the disease in the country, and thus globally. In the absence of quality surveillance data on privately treated patients, commercial drug sales data offer an empirical foundation for disease burden estimation. Methods We used a large, nationally representative commercial dataset on sales of 189 anti-tuberculosis products available in India to calculate the amount of anti-tuberculosis treatment in the private sector in 2013–14. We corrected estimates using validation studies that audited prescriptions against tuberculosis diagnosis, and estimated uncertainty using Monte Carlo simulation. To address implications for numbers of patients with tuberculosis, we explored varying assumptions for average duration of tuberculosis treatment and accuracy of private diagnosis. Findings There were 17·793 million patient-months (95% credible interval 16·709 million to 19·841 million) of anti-tuberculosis treatment in the private sector in 2014, twice as many as the public sector. If 40–60% of private-sector tuberculosis diagnoses are correct, and if private-sector tuberculosis treatment lasts on average 2–6 months, this implies that 1·19–5·34 million tuberculosis cases were treated in the private sector in 2014 alone. The midpoint of these ranges yields an estimate of 2·2 million cases, two to three times higher than currently assumed. Interpretation India's private sector is treating an enormous number of patients for tuberculosis, appreciably higher than has been previously recognised. Accordingly, there is a re-doubled need to address this burden and to strengthen surveillance. Tuberculosis burden estimates in India and worldwide require revision

Marked improvement of cytotoxic effects induced by docetaxel on highly metastatic and androgen-independent prostate cancer cells by downregulating macrophage inhibitory cytokine-1.

BACKGROUND: Overexpression of macrophage inhibitory cytokine-1 (MIC-1) frequently occurs during the progression of prostate cancer (PC) to androgen-independent (AI) and metastatic disease states and is associated with a poor outcome of patients. METHODS: The gain- and loss-of-function analyses of MIC-1 were performed to establish its implications for aggressive and chemoresistant phenotypes of metastatic and AI PC cells and the benefit of its downregulation for reversing docetaxel resistance. RESULTS: The results have indicated that an enhanced level of secreted MIC-1 protein in PC3 cells is associated with their acquisition of epithelial-mesenchymal transition features and higher invasive capacity and docetaxel resistance. Importantly, the downregulation of MIC-1 in LNCaP-LN3 and PC3M-LN4 cells significantly decreased their invasive capacity and promoted the antiproliferative, anti-invasive and mitochrondrial- and caspase-dependent apoptotic effects induced by docetaxel. The downregulation of MIC-1 in PC3M-LN4 cells was also effective in promoting the cytotoxic effects induced by docetaxel on the side population (SP) endowed with stem cell-like properties and the non-SP cell fraction from PC3M-LN4 cells. CONCLUSION: These data suggest that the downregulation of MIC-1 may constitute a potential therapeutic strategy for improving the efficacy of current docetaxel-based chemotherapies, eradicating the total mass of PC cells and thereby preventing disease relapse and the death of PC patients

Analysis of location uncertainty for a microearthquake cluster: A case study

In many reservoirs, an increase in permeability and conductivity is achieved by hydraulic fracturing/stimulations which open cracks and fractures that then act as pathways for fluids to navigate in the subsurface. Mapping, localization, and general characterization of these fracture systems is of key importance in oil, gas, and geothermal energy production. The location of the microseismic events triggered during hydraulic fracturing or stimulation can help to characterize the properties of the fracture system. There are many different methods for localizing microearthquakes and, in general, these methods yield different locations, velocity models, and event origin times, due to differences in algorithms and input models. Here we focus on studying location confidence intervals associated with two localization methods, classical (triangulation) and Double-Difference, where uncertainties due to origin times can be marginalized away, thus decreasing uncertainties in the event locations. We relocate events using these two methods and three different velocity models. Of the two methods used here, Double-Difference produces smallest confidence regions. We also illustrate that, for our dataset in particular, marginalizing away the influence of the unknown origin times also improves the confidence intervals

Structure of aluminum atomic chains

First-principles density functional calculations reveal that aluminum can form planar chains in zigzag and ladder structures. The most stable one has equilateral triangular geometry with four nearest neighbors; the other stable zigzag structure has wide bond angle and allows for two nearest neighbors. An intermediary structure has the ladder geometry and is formed by two strands. All these planar geometries are, however, more favored energetically than the linear chain. We found that by going from bulk to a chain the character of bonding changes and acquires directionality. The conductance of zigzag and linear chains is 4e^2/h under ideal ballistic conditions.Comment: modified detailed version, one new structure added, 4 figures, modified figure1, 1 tabl

Multi-Channel Transport in Disordered Medium under Generic Scattering Conditions

Our study of the evolution of transmission eigenvalues, due to changes in various physical parameters in a disordered region of arbitrary dimensions, results in a generalization of the celebrated DMPK equation. The evolution is shown to be governed by a single complexity parameter which implies a deep level of universality of transport phenomena through a wide range of disordered regions. We also find that the interaction among eigenvalues is of many body type that has important consequences for the statistical behavior of transport properties.Comment: 19 Pages, No Figure

Expression of tumor-associated glycoprotein-72 (TAG-72) antigen in human prostatic adenocarcinomas.

Tumor-specific antigens are usually defined by monoclonal antibodies (MAbs) and can play critical roles in the diagnosis and therapy of carcinomas. Despite advances in the understanding of the molecular genetics of human prostate carcinomas, therapeutic approaches require that tumor-specific markers, preferably on the cell surface, should be defined. In this study, we examined the expression of an oncofetal antigen tumor-associated glycoprotein-72 (TAG-72) in prostatic adenocarcinomas with a Gleason grade of six or higher. Using a second generation MAb CC49 against TAG-72, immunoreactivity was detected in 88% (29/33) of the prostatic cancer tissues. Occasionally, the benign epithelium showed a very faint immunostaining but in most of the specimens, no reactivity was detected. Positive staining was present in the cytoplasm and the cell membrane of the malignant cells similar to reports on other cancer tissues. A weaker staining pattern of this antigen was seen in poorly differentiated areas. A significant negative correlation (r = -0.36, p \u3c 0.05) was observed between TAG-72 antigen expression and Gleason grade. The TAG-72 antigen expression in prostatic adenocarcinomas may be used as a target for radioimmunotherapy by the multivalent single chain antibody CC49 constructs recently generated by our group