Leishmania manipulation of sand fly feeding behavior results in enhanced transmission.

In nature the prevalence of Leishmania infection in whole sand fly populations can be very low (<0.1%), even in areas of endemicity and high transmission. It has long since been assumed that the protozoan parasite Leishmania can manipulate the feeding behavior of its sand fly vector, thus enhancing transmission efficiency, but neither the way in which it does so nor the mechanisms behind such manipulation have been described. A key feature of parasite development in the sand fly gut is the secretion of a gel-like plug composed of filamentous proteophosphoglycan. Using both experimental and natural parasite-sand fly combinations we show that secretion of this gel is accompanied by differentiation of mammal-infective transmission stages. Further, Leishmania infection specifically causes an increase in vector biting persistence on mice (re-feeding after interruption) and also promotes feeding on multiple hosts. Both of these aspects of vector behavior were found to be finely tuned to the differentiation of parasite transmission stages in the sand fly gut. By experimentally accelerating the development rate of the parasites, we showed that Leishmania can optimize its transmission by inducing increased biting persistence only when infective stages are present. This crucial adaptive manipulation resulted in enhanced infection of experimental hosts. Thus, we demonstrate that behavioral manipulation of the infected vector provides a selective advantage to the parasite by significantly increasing transmission

Thermoelectric bonding study. the bonding of pbte and pbte-snte with non-magnetic electrodes

Low resistance, high strength, nonmagnetic electrode bonding to lead telluride and lead- telluride-tin telluride alloy

Lead telluride non-magnetic bonding research study Second quarterly report, 1 Jun. - 31 Aug. 1965

Diffusion and braze bonding of tungsten and tantalum to lead telluride and lead telluride- tin telluride thermoelectric alloy

Lead telluride non-magnetic bonding research study Third quarterly report, Sep. 1 - Nov. 30, 1965

Diffusion bonding of tungsten electrodes to lead tellurium and lead tellurium-tin tellurium thermocouple

Do Agglomeration Economies Exist in the Hospital Services Industry

Given the importance of knowledge flows and the continued emphasis on face-to-face encounters especially for medical care, close proximity of hospitals may be essential for the efficient delivery of medical care. That is, hospital productivity might be greater where hospitals cluster and allow knowledge to more easily and quickly disperse among personnel in the various organizations. To add to the understanding about agglomeration economies in the hospital services sector, this study analyzes how the clustering of hospitals in the various metropolitan areas of the US affects industry wide productivity. The multiple regression analysis is conducted on a cross-sectional basis for both 1993 and 1999 and by using first differencing of the data between the two years. The observed productivity improvements resulting from the clustering of hospitals provides yet another justification for encouraging a larger number of hospitals in metropolitan areas.

Properties of real metallic surfaces: Effects of density functional semilocality and van der Waals nonlocality

We have computed the surface energies, work functions, and interlayer surface relaxations of clean (111), (110), and (100) surfaces of Al, Cu, Ru, Rh, Pd, Ag, Pt, and Au. Many of these metallic surfaces have technological or catalytic applications. We compare experimental reference values to those of the local density approximation (LDA), the Perdew-Burke-Ernzerhof (PBE) generalized gradient approximation (GGA), the PBEsol (PBE for solids) GGA, the SCAN meta-GGA, and SCAN+rVV10 (SCAN with a long-range van der Waals or vdW correction). The closest agreement with uncertain experimental values is achieved by the simplest density functional (LDA) and by the most sophisticated general-purpose one (SCAN+rVV10). The long-range vdW interaction increases the surface energies by about 10%, and the work functions by about 1%. LDA works for metal surfaces through a stronger-than-usual error cancellation. PBE yields the most-underestimated and presumably least accurate surface energies and work functions. Surface energies within the random phase approximation (RPA) are also reported. Interlayer relaxations from different functionals are in reasonable agreement with one another, and usually with experiment

Lead telluride bonding and segmentation study Semiannual phase report, 1 Feb. - 31 Jul. 1969

Thermoelectric system of Cd-Si-Ge, and tungsten diffusion bonded lead tellurid