161 research outputs found
Time-Fractional Optimal Control of Initial Value Problems on Time Scales
We investigate Optimal Control Problems (OCP) for fractional systems
involving fractional-time derivatives on time scales. The fractional-time
derivatives and integrals are considered, on time scales, in the
Riemann--Liouville sense. By using the Banach fixed point theorem, sufficient
conditions for existence and uniqueness of solution to initial value problems
described by fractional order differential equations on time scales are known.
Here we consider a fractional OCP with a performance index given as a
delta-integral function of both state and control variables, with time evolving
on an arbitrarily given time scale. Interpreting the Euler--Lagrange first
order optimality condition with an adjoint problem, defined by means of right
Riemann--Liouville fractional delta derivatives, we obtain an optimality system
for the considered fractional OCP. For that, we first prove new fractional
integration by parts formulas on time scales.Comment: This is a preprint of a paper accepted for publication as a book
chapter with Springer International Publishing AG. Submitted 23/Jan/2019;
revised 27-March-2019; accepted 12-April-2019. arXiv admin note: substantial
text overlap with arXiv:1508.0075
Surveillance of mother-to-child HIV transmission: socioeconomic and health care coverage indicators
Evaluation of condyle defects using different reconstruction protocols of cone-beam computed tomography
Prime movers : mechanochemistry of mitotic kinesins
Mitotic spindles are self-organizing protein machines that harness teams of multiple force generators to drive chromosome segregation. Kinesins are key members of these force-generating teams. Different kinesins walk directionally along dynamic microtubules, anchor, crosslink, align and sort microtubules into polarized bundles, and influence microtubule dynamics by interacting with microtubule tips. The mechanochemical mechanisms of these kinesins are specialized to enable each type to make a specific contribution to spindle self-organization and chromosome segregation
Tratamento endovascular das doenças da aorta toråcica: anålise dos resultados de um centro
Antibacterial Characterization of Novel Synthetic Thiazole Compounds against Methicillin-Resistant Staphylococcus pseudintermedius
Staphylococcus pseudintermedius is a commensal organism of companion animals that is a significant source of opportunistic infections in dogs. With the emergence of clinical isolates of S. pseudintermedius (chiefly methicillin-resistant S. pseudintermedius (MRSP)) exhibiting increased resistance to nearly all antibiotic classes, new antimicrobials and therapeutic strategies are urgently needed. Thiazole compounds have been previously shown to possess potent antibacterial activity against multidrug-resistant strains of Staphylococcus aureus of human and animal concern. Given the genetic similarity between S. aureus and S. pseudintermedius, this study explores the potential use of thiazole compounds as novel antibacterial agents against methicillin-sensitive S. pseudintermedius (MSSP) and MRSP. A broth microdilution assay confirmed these compounds exhibit potent bactericidal activity (at sub-microgram/mL concentrations) against both MSSA and MRSP clinical isolates while the MTS assay confirmed three compounds (at 10 ÎŒg/mL) were not toxic to mammalian cells. A time-kill assay revealed two derivatives rapidly kill MRSP within two hours. However, this rapid bactericidal activity was not due to disruption of the bacterial cell membrane indicating an alternative mechanism of action for these compounds against MRSP. A multistep resistance selection analysis revealed compounds 4 and 5 exhibited a modest (twofold) shift in activity over ten passages. Furthermore, all six compounds (at a subinihibitory concentration) demonstrated the ability to re-sensitize MRSP to oxacillin, indicating these compounds have potential use for extending the therapeutic utility of ÎČ-lactam antibiotics against MRSP. Metabolic stability analysis with dog liver microsomes revealed compound 3 exhibited an improved physicochemical profile compared to the lead compound. In addition to this, all six thiazole compounds possessed a long post-antibiotic effect (at least 8 hours) against MRSP. Collectively the present study demonstrates these synthetic thiazole compounds possess potent antibacterial activity against both MSSP and MRSP and warrant further investigation into their use as novel antimicrobial agents
Fatores associados Ă vulnerabilidade de idosos vivendo com HIV/AIDS em Belo Horizonte (MG), Brasil
Impact of oral health on physical and psychosocial dimensions: an analysis using structural equation modeling
Evaluation of preoperative computed tomography angiography in association with conventional angiography versus computed tomography angiography only, in the endovascular treatment of aortic diseases
Innovation Practices in Emerging Economies: Do University Partnerships Matter?
Enterprisesâ resources and capabilities determine their ability to achieve competitive advantage. In this regard, the key innovation challenges that enterprises face are liabilities associated with their age and size, and the entry barriers imposed on them. In this line, a growing number of enterprises are starting to implement innovation practices in which they employ both internal/external flows of knowledge in order to explore/exploit innovation in collaboration with commercial or scientific agents. Within this context, universities play a significant role providing fertile knowledge-intensive environments to support the exploration and exploitation of innovative and entrepreneurial ideas, especially in emerging economies, where governments have created subsidies to promote enterprise innovation through compulsory university partnerships. Based on these ideas, the purpose of this exploratory research is to provide a better understanding about the role of universities on enterprisesâ innovation practices in emerging economies. More concretely, in the context of Mexico, we explored the enterprisesâ motivations to collaborate with universities in terms of innovation purposes (exploration and exploitation) or alternatives to access to public funds (compulsory requirement of being involved in a university partnership). Using a sample of 10,167 Mexican enterprises in the 2012 Research and Technological Development Survey collected by the Mexican National Institute of Statistics and Geography, we tested a multinomial regression model. Our results provide insights about the relevant role of universities inside enterprisesâ exploratory innovation practices, as well as, in the access of R&D research subsidies
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