Jan Łukasiewicz contre le dictum de omni et de nullo

L’article explore les raisons pour lesquelles Łukasiewicz dans son exposé refuse de prendre en compte le dictum de omni et de nullo en qualité d’axiome de la syllogistique aristotélicienne. Après avoir établi la faiblesse de l’argumentation textuelle de Łukasiewicz, il est montré que les réserves de Łukasiewicz à l’égard du dictum doivent être recherchées dans un anti-essentialisme qui lui interdit de suivre Aristote jusqu’au bout de sa logique.This paper explores the reasons why Łukasiewicz in his explanation of Aristotelian syllogistic does not accept the dictum de omni et de nullo as an axiom. After having established the fragility of the textual argumentation of Łukasiewicz, it is shown that his reasons for being reserved about the dictum must be found in a anti-essentialism which forbids Łukasiewicz to follow Aristotle all the way to the ontological foundation of his logic

Liminaire

Parmi les thèmes qui font l’objet des recherches des Archives Poincaré, la logique polonaise occupe une place importante justifiée à la fois par la valeur et la place de cette logique novatrice dans l’histoire de la logique moderne et par le rôle indispensable qu’elle a joué dans le développement d’une science de la logique accompagnant les progrès de la science et pouvant lui fournir ainsi un instrument adapté de raisonnement. La valeur des travaux de cette école, dite de Lwow-Warszawa, se m..

Bibliographie exhaustive de Jerzy Kalinowski

Introduction La présente bibliographie a été constituée sur la base de celle parue en 1995-1996, sous le titre de “Bibliografia podmiotowa i przedmiotowa Profesora Jerzego Kalinowskiego”, Summarium 24-25 (44-45), Lublin, 1995-1996, elle-même inspirée, en ce qui concerne les années antérieures à 1983, de la bibliographie établie par R. Bozzi, La logique deontica di Georges Kalinowski , Naples, 1984, 193-204. Nous l’avons completée par..

Éditorial (incipit)

Philosophia Scientiae a souhaité rendre hommage à un philosophe contemporain d’expression française, Jerzy (Georges) Kalinowski. Il nous est apparu en effet que son œuvre, novatrice dans le champ de la logique, spécialement de la logique des normes, mérite en France une reconnaissance qu’elle n’a pas encore pleinement reçue. Les raisons de cette relative méconnaissance, surtout dans le contexte français, sont nombreuses, si l’on songe aux difficultés que peut représenter, pour la pensée franç..

Effect of a switch of aromatase inhibitors on musculoskeletal symptoms in postmenopausal women with hormone-receptor-positive breast cancer: the ATOLL (articular tolerance of letrozole) study

International audienceThe objective of the present study was to evaluate the effect of the switch of aromatase inhibitors (AIs) on musculoskeletal symptoms in postmenopausal women with hormone-receptor-positive breast cancer. This was a 6-month, prospective, non-randomized, multicenter study. Patients who had discontinued anastrozole due to musculoskeletal symptoms were eligible to participate in this study, and received letrozole, which was initiated 1 month after anastrozole discontinuation. Musculoskeletal symptoms were systematically assessed for severity, location of the symptoms, presence of swelling and of morning stiffness by the oncologist patients when patients stopped taking their anastrozole, 1 month after the discontinuation of anastrozole, and 1, 3, and 6 months after initiating the letrozole therapy. The primary endpoint was the percentage of patients who discontinued letrozole due to the severe musculoskeletal symptoms. After switching from anastrozole therapy, and at the end of the 6-month letrozole treatment, 128 (71.5%) out of 179 patients (61.3 ± 8.4 years) continued with letrozole. Fifty-one patients (28.5%) discontinued treatment due to severe joint pain. At the end of the 6-month, 116 patients (73.9%) had arthralgia, 33 (21.0%) myalgia, 25 (15.9%) arthritis, 22 (14.0%) tendinitis, and 20 (12.7%) polyalgic syndrome. Bivariate analysis of the factors associated with letrozole discontinuation showed that the duration of a prior anastrozole treatment was a significant predictor ( = 0.04). This study shows that in patients intolerant to one AI, switching to another agent allows a higher proportion of patients to continue the therapy and maximize hormonal adjuvant therapy and disease outcome benefits

Heterologous Systemic Prime–Intranasal Boosting Using a Spore SARS-CoV-2 Vaccine Confers Mucosal Immunity and Cross-Reactive Antibodies in Mice as well as Protection in Hamsters

Background: Current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are administered systemically and typically result in poor immunogenicity at the mucosa. As a result, vaccination is unable to reduce viral shedding and transmission, ultimately failing to prevent infection. One possible solution is that of boosting a systemic vaccine via the nasal route resulting in mucosal immunity. Here, we have evaluated the potential of bacterial spores as an intranasal boost. Method: Spores engineered to express SARS-CoV-2 antigens were administered as an intranasal boost following a prime with either recombinant Spike protein or the Oxford AZD1222 vaccine. Results: In mice, intranasal boosting following a prime of either Spike or vaccine produced antigen-specific sIgA at the mucosa together with the increased production of Th1 and Th2 cytokines. In a hamster model of infection, the clinical and virological outcomes resulting from a SARS-CoV-2 challenge were ameliorated. Wuhan-specific sIgA were shown to cross-react with Omicron antigens, suggesting that this strategy might offer protection against SARS-CoV-2 variants of concern. Conclusions: Despite being a genetically modified organism, the spore vaccine platform is attractive since it offers biological containment, the rapid and cost-efficient production of vaccines together with heat stability. As such, employed in a heterologous systemic prime–mucosal boost regimen, spore vaccines might have utility for current and future emerging diseases.info:eu-repo/semantics/publishedVersio