Burkitt lymphoma with a granulomatous reaction: an M1/Th1-polarised microenvironment is associated with controlled growth and spontaneous regression

Aims: Burkitt lymphoma (BL) is an aggressive B-cell lymphoma that, in some instances, may show a granulomatous reaction associated with a favourable prognosis and occasional spontaneous regression. In the present study, we aimed to define the tumour microenvironment (TME) in four such cases, two of which regressed spontaneously. Methods and results: All cases showed aggregates of tumour cells with the typical morphology, molecular cytogenetics and immunophenotype of BL surrounded by a florid epithelioid granulomatous reaction. All four cases were Epstein–Barr virus (EBV)-positive with type I latency. Investigation of the TME showed similar features in all four cases. The analysis revealed a proinflammatory response triggered by Th1 lymphocytes and M1 polarised macrophages encircling the neoplastic cells with a peculiar topographic distribution. Conclusions: Our data provide an in-vivo picture of the role that specific immune cell subsets might play during the early phase of BL, which may be capable of maintaining the tumour in a self-limited state or inducing its regression. These novel results may provide insights into new potential therapeutic avenues in EBV-positive BL patients in the era of cellular immunotherapy

ROBOTIC RADICAL HYSTERECTOMY: SYNCHRONOUS PRIMARY SQUAMOUS CARCINOMA OF THE CERVIX AND PSAMMOMATOUS CARCINOMA OF THE OVARY: A RARE ASSOCIATION

WOS: 000330379501361

ENDOCERVICAL GLANDULAR INVOLVEMENT, MULTICENTRICITY AND EXTENT OF THE DISEASE ARE FEATURES OF HIGH GRADE CERVICAL INTRAEPITHELIAL NEOPLASIA

WOS: 000330379501377

Bilateral vulvar mass mimicking Bartholin's gland abscess in the postpartum period: Klippel-Trenaunay Syndrome

WOS: 000337902500022PubMed ID: 24766189

Radiologic diagnosis of a type-III pleuropulmonary blastoma

PubMed ID: 25786292Pleuropulmonary blastoma (PPB) is a rare and aggressive dysontogenic neoplasm, occurring in children under the age of 6 years in most cases. CT and MRI findings are well-known, a mixed solid and cystic lesion with variable contrast enhancement and a necrotic centre. We report the radiologic features of type III PPB case

Clinical importance of detection of bacterial vaginosis, trichomonas vaginalis, candida albicans and actinomyces in Papanicolaou smears

WOS: 000308510700015PubMed ID: 23157037Objective: The aim of this study was to determine the role of Papanicolaou (pap) smears in the diagnosis of lower genital tract infections. Materials and Methods: A retrospective study was planned by reviewing charts of patients for trichomonas vaginalis, bacterial vaginosis, actinomyces, candida and nonspecific vaginitis. Results: Charts of 9,080 patients were reviewed and 1,733 women had a diagnosis of lower genital tract infection in the pap smear or had had a clinically treated lower genital tract infection. Only 33.5%, 30.4%, 43.3%, and 0% of patients with bacterial vaginosis, trichomonas vaginalis, candida and actinomyces, respectively on pap smear were diagnosed and treated clinically. Postmenopausal patients had a higher rate of trichomonas vaginalis infection and a lower rate of candida infection when compared to women of the reproductive age group. Patients using an intrauterine device for contraception had a statistically significantly increased rate of trichomonas vaginalis and candida infection when compared to women using other contraceptive methods or those who were not using any contraception. Conclusions: Finding trichomonas vaginalis, bacterial vaginosis and actinomyces infections in pap smears might be considered an indication for treatment without performing other diagnostic tests. Treatment of asymptomatic infections can prevent complications in selected patients. Candida can be a commensal bacteria in the vagina, therefore asymptomatic patients may not require treatment. Detection of a higher rate of trichomonas vaginalis and candida infection in IUD users shows that IUDs can increase the risk of vaginal infections and associated complications

Clinicopathological and immunohistochemical evaluation of cholangiocarcinoma, cholangiolocarcinoma, hepatocellular carcinoma and mixed hepatocellular carcinoma and cholangiocarcinoma

WOS: 000323904201216

Malignant primary peritoneal mesothelioma: report of two cases and review of literature

WOS: 000309738600027PubMed ID: 23185811Introduction: Malignant primary peritoneal mesothelioma is a rare and highly aggressive tumor. This tumor can be misdiagnosed as ovarian carcinoma. Case: Two cases of malignant primary peritoneal mesothelioma that were misdiagnosed as ovarian carcinoma were operated in our instutition. Patients were 74 and 45 years-old at admittance. Conclusion: Malignant primary peritoneal mesothelioma is being a problem for gynecologic oncologists because of the close similarity with epithelial ovarian cancer. Diagnosis and treatment of these patients are still under debate

The relation of BRAF V600E Mutation and microsatellite instability in colorectal carcinomas

WOS: 000310364801544