8,787 research outputs found
Current medical treatment of estrogen receptor-positive breast cancer
Approximately 80% of breast cancers (BC) are estrogen receptor (ER)-positive and thus endocrine therapy (ET) should be considered complementary to surgery in the majority of patients. The advantages of oophorectomy, adrenalectomy and hypophysectomy in women with advanced BC have been demonstrated many years ago, and currently ET consist of (i) ovarian function suppression (OFS), usually obtained using gonadotropin-releasing hormone agonists (GnRHa), (ii) selective estrogen receptor modulators or down-regulators (SERMs or SERDs), (iii) aromatase inhibitors (AIs), or a combination of two or more drugs. For patients aged less than 50 years and ER+ BC, there is no conclusive evidence that the combination of OFS and SERMs (i.e. tamoxifen) or chemotherapy is superior to OFS alone. Tamoxifen users exhibit a reduced risk of BC, both invasive and in situ, especially during the first 5 years of therapy, and extending the treatment to 10 years further reduced the risk of recurrences. SERDs (i.e. fulvestrant) are especially useful in the neoadjuvant treatment of advanced BC, alone or in combination with either cytotoxic agents or AIs. There are two types of AIs: type I are permanent steroidal inhibitors of aromatase, while type II are reversible nonsteroidal inhibitors. Several studies demonstrated the superiority of the third-generation AIs (i.e. anastrozole and letrozole) compared with tamoxifen, and adjuvant therapy with AIs reduces the recurrence risk especially in patients with advanced BC. Unfortunately, some cancers are or became ET-resistant, and thus other drugs have been suggested in combination with SERMs or AIs, including cyclin-dependent kinase 4/6 inhibitors (palbociclib) and mammalian target of rapamycin (mTOR) inhibitors, such as everolimus. Further studies are required to confirm their real usefulness
Tree Level Unitarity Bounds for the Minimal B-L Model
We have derived the unitarity bounds in the high energy limit for the minimal
B-L extension of the Standard Model by analysing the full class of Higgs and
would-be Goldstone boson two-to-two scatterings at tree level. Moreover, we
have investigated how these limits could vary at some lower critical value of
the energy.Comment: 20 pages, 4 figures, 2 tables; 1d figure modified, typos corrected,
bibliography augmented; published in PRD after minor adjustmen
The Z' boson of the minimal B-L model at future Linear Colliders in e+e- --> mu+mu-
We study the capabilities of future electron-positron Linear Colliders, with
centre-of-mass energy at the TeV scale, in accessing the parameter space of a
boson within the minimal model. We carry out a detailed comparison
between the discovery regions mapped over a two-dimensional configuration space
( mass and coupling) at the Large Hadron Collider and possible future
Linear Colliders for the case of di-muon production. As known in the literature
for other models, we confirm that leptonic machines, as compared to the
CERN hadronic accelerator, display an additional potential in discovering a
boson as well as in allowing one to study its properties at a level of
precision well beyond that of any of the existing colliders.Comment: 5 pages, proceeding of LC09 (Perugia), published by the Italian
Physical Society in the Nuovo Cimento C (Colloquia
Photon and Pomeron -- induced production of Dijets in , and collisions
In this paper we present a detailed comparison of the dijet production by
photon -- photon, photon -- pomeron and pomeron -- pomeron interactions in
, and collisions at the LHC energy. The transverse
momentum, pseudo -- rapidity and angular dependencies of the cross sections are
calculated at LHC energy using the Forward Physics Monte Carlo (FPMC), which
allows to obtain realistic predictions for the dijet production with two
leading intact hadrons. We obtain that \gamma \pom channel is dominant at
forward rapidities in collisions and in the full kinematical range in the
nuclear collisions of heavy nuclei. Our results indicate that the analysis of
dijet production at the LHC can be useful to test the Resolved Pomeron model as
well as to constrain the magnitude of the absorption effects.Comment: 11 pages, 6 figures, 1 table. Improved and enlarged version published
in European Physical Journal
Inclusive hadron and photon production at LHC in dipole momentum space
Using a momentum space model for the dipole scattering amplitude we present
an analysis of the saturation effects at LHC energies, describing the data on
proton-proton and proton-lead collisions. The model is based on the asymptotic
solutions of the Balitsky-Kovchegov equation, being ideal in the saturation
domain where the target wave function has a high occupation number. We also
make predictions for the nuclear modification ratios on charged hadron and
prompt photon production in the forward region, where the high parton density
effects are important.Comment: New section added and typos corrected. To be published in PR
Strengthening measurements from the edges: application-level packet loss rate estimation
Network users know much less than ISPs, Internet exchanges and content providers about what happens inside the network. Consequently users cannot either easily detect network neutrality violations or readily exercise their market power by knowledgeably switching ISPs. This paper contributes to the ongoing efforts to empower users by proposing two models to estimate -- via application-level measurements -- a key network indicator, i.e., the packet loss rate (PLR) experienced by FTP-like TCP downloads. Controlled, testbed, and large-scale experiments show that the Inverse Mathis model is simpler and more consistent across the whole PLR range, but less accurate than the more advanced Likely Rexmit model for landline connections and moderate PL
Phenomenology of the minimal B-L extension of the Standard Model
We present the Large Hadron Collider (LHC) discovery potential in the
and heavy neutrino sectors of a enlarged Standard Model also
encompassing three heavy Majorana neutrinos. This model exhibits novel
signatures at the LHC, the most interesting arising from a decay chain
involving heavy neutrinos, eventually decaying into leptons and jets. In
particular, this signature allows one to measure the and heavy neutrino
masses involved. In addition, over a large region of parameter space, the heavy
neutrinos are rather long-lived particles producing distinctive displaced
vertices that can be seen in the detectors. Lastly, the simultaneous
measurement of both the heavy neutrino mass and decay length enables an
estimate of the absolute mass of the parent light neutrino. For completeness,
we will also compare the LHC and a future Linear Collider (LC) discovery
potentials.Comment: 4 pages, no figures. LaTeX. Talk given at "The 2009 Europhysics
Conference on High Energy Physics", Krakow, Poland, July 16-22, 200
A new genus of neobatrachian frog from southern Patagonian forests, Argentina and Chile
In 1975 Lynch named a new species of frog based on two specimens from Puerto Eden, Wellington Island, southern Chile, tentatively allocated to the genus Telmatobius. Telmatobius grandisonae Lynch was later included by the same author in his genus Atelognathus. Based on a reappraisal of the type material and the description of the internal and external morphology, karyotype, tadpole morphology and molecular evidence from recently discovered specimens collected at Lago del Desierto, southern Argentina, we describe the monotypic genus Chaltenobatrachus, with Telmatobius grandisonae (Lynch) serving as the type species. Chaltenobatrachus differs from Atelognathus mainly in having a uniform bright green dorsal coloration, with brown to reddish warts; orange iris with gold spots; fingers with interdigital membrane; frontoparietals well developed, small nasals; well ossified sphenethmoid; anteriorly expanded homosternum; skin of tadpole transparent; oral disc with protruding anterior and lateral papillae; diploid number 2n = 32 chromosomes. The genetic distances between Chaltenobatrachus and Atelognathus meet or exceed most other intergeneric comparisons.Fil: Basso, Nestor Guillermo. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: Úbeda, Carmen A.. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Bunge, Maria M.. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Martinazzo Giménez, Liza Beatriz. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro Nacional Patagónico; Argentin
Longitudinal spin Seebeck coefficient: heat flux vs. temperature difference method
The determination of the longitudinal spin Seebeck effect (LSSE) coefficient
is currently plagued by a large uncertainty due to the poor reproducibility of
the experimental conditions used in its measurement. In this work we present a
detailed analysis of two different methods used for the determination of the
LSSE coefficient. We have performed LSSE experiments in different laboratories,
by using different setups and employing both the temperature difference method
and the heat flux method. We found that the lack of reproducibility can be
mainly attributed to the thermal contact resistance between the sample and the
thermal baths which generate the temperature gradient. Due to the variation of
the thermal resistance, we found that the scaling of the LSSE voltage to the
heat flux through the sample rather than to the temperature difference across
the sample greatly reduces the uncertainty. The characteristics of a single
YIG/Pt LSSE device obtained with two different setups was Vm/W and Vm/W with the heat flux method
and V/K and V/K
with the temperature difference method. This shows that systematic errors can
be considerably reduced with the heat flux method.Comment: PDFLaTeX, 10 pages, 6 figure
Direct calorimetric measurements of isothermal entropy change on single crystal W-type hexaferrites at the spin reorientation transition
We report on the magnetic field induced isothermal entropy change, \Delta
s(Ha, T), of W-type ferrite with CoZn substitution. Entropy measurements are
performed by direct calorimetry. Single crystals of the composition
BaCoZnFeO, prepared by the flux method, are measured at
different fixed temperatures under an applied field perpendicular and parallel
to the c axis. At 296 K one deduces a value of K = 8.7 \times 10^{4} J
m for the first anisotropy constant, which is in good agreement with the
literature. The spin reorientation transition temperature is estimated to take
place between 200 and 220 K
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