1,105 research outputs found
Theory of phase-locking in generalized hybrid Josephson junction arrays
A recently proposed scheme for the analytical treatment of the dynamics of
two-dimensional hybrid Josephson junction arrays is extended to a class of
generalized hybrid arrays with ''horizontal'' shunts involving a capacitive as
well as an inductive component. This class of arrays is of special interest,
because the internal cell coupling has been shown numerically to favor in-phase
synchronization for certain parameter values. As a result, we derive limits on
the circuit design parameters for realizing this state. In addition, we obtain
formulas for the flux-dependent frequency including flux-induced switching
processes between the in-phase and anti-phase oscillation regime. The treatment
covers unloaded arrays as well as arrays shunted via an external load.Comment: 24 pages, REVTeX, 5 Postscript figures, Subm. to Phys. Rev.
Intrinsic mechanism of phase locking in two-dimensional Josephson junction networks in presence of an external magnetic field
We present numerical simulations of the dynamics of two-dimensional Josephson
junction arrays to study the mechanism of mutual phase locking. We show that in
the presence of an external magnetic field two mechanisms are playing a role in
phase locking: feedback through the external load and internal coupling between
rows due to microwave currents induced by the field. We have found the
parameter values (junction capacitance, cell loop inductance, impedance of the
external load) for which the interplay of both these mechanisms leads to the
in-phase solution. The case of unshunted arrays is discussed as well.Comment: 13 pages, incl. 6 ps figures, Subm. to Europhysics Letter
Subgroup B Adenovirus Type 35 Early Region 3 mRNAs Differ from Those of the Subgroup C Adenoviruses
AbstractAdenovirus type 35 (Ad35) is a member of Ad subgroup B, DNA homology cluster B2. The B2 Ads are unique in that they are isolated most frequently from immunosupressed individuals such as AIDS patients and bone marrow transplant recipients and in that they have a tropism for the urinary tract. One region of the Ad genome which may influence serotype specific pathology is early region 3 (E3). E3 of subgroup C Ad2 and Ad5 has been shown to encode proteins which counteract the immune response to Ad infection. While a great deal is known about gene expression of the subgroup C Ad E3s, little is known about the E3 gene expression from the subgroup B Ads. Although some E3 open reading frames (ORFs) are shared between subgroups B and C, there are additional ORFs that appear in subgroup B. This paper demonstrates the results of an analysis of gene expression from the Ad35 E3 and describes differences in splicing and polyadenylation between the Ad35 and Ad2 E3s. RT–PCR, cDNA sequencing, RNase protection, 3′ RACE, and Northern blotting techniques were utilized to identify, quantify, and determine the structure of six Ad35 E3 mRNAs predicted to encode at least seven proteins. A common intron that is removed during splicing of the subgroup C E3 mRNAs is not removed from Ad35 E3 mRNAs, and only one E3 polyadenylation signal is present in the Ad35 E3 while two polyadenylation signals are used in the formation of subgroup C E3 mRNAs. The quantity of individual mRNAs encoding homologous proteins for Ad35 and Ad2 also differ substantially, presumably because of the absence in Ad35 ofcis-acting signals which have been shown to be important for regulation of Ad2 E3 pre-mRNA processing. Such information should contribute to an understanding of the role the E3 plays in determining subgroup B Ad pathogenesis in general and Ad35 pathogenesis in particular
Regular and Irregular Boundary Conditions in the AdS/CFT Correspondence
We expand on Klebanov and Witten's recent proposal for formulating the
AdS/CFT correspondence using irregular boundary conditions. The proposal is
shown to be correct to any order in perturbation theory.Comment: 7 pages, typos correcte
Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis
Ebola virus VP35 inhibits alpha/beta interferon production and functions as a viral polymerase cofactor. Previously, the 8-kDa cytoplasmic dynein light chain (LC8) was demonstrated to interact with VP35, but the functional consequences were unclear. Here we demonstrate that the interaction is direct and of high affinity and that binding stabilizes the VP35 N-terminal oligomerization domain and enhances viral RNA synthesis. Mutational analysis demonstrates that VP35 interaction is required for the functional effects of LC8
Instabilities in Josephson Ladders with Current Induced Magnetic Fields
We report on a theoretical analysis, consisting of both numerical and
analytic work, of the stability of synchronization of a ladder array of
Josephson junctions under the influence of current induced magnetic fields.
Surprisingly, we find that as the ratio of the mutual to self inductance of the
cells of the array is increased a region of unstable behavior occurs followed
by reentrant stable synchronization. Analytic work tells us that in order to
understand fully the cause of the observed instabilities the behavior of the
vertical junctions, sometimes ignored in analytic analyses of ladder arrays,
must be taken into account.Comment: RevTeX, 4 pages, 3 figure
Deriving Boltzmann Equations from Kadanoff-Baym Equations in Curved Space-Time
To calculate the baryon asymmetry in the baryogenesis via leptogenesis
scenario one usually uses Boltzmann equations with transition amplitudes
computed in vacuum. However, the hot and dense medium and, potentially, the
expansion of the universe can affect the collision terms and hence the
generated asymmetry. In this paper we derive the Boltzmann equation in the
curved space-time from (first-principle) Kadanoff-Baym equations. As one
expects from general considerations, the derived equations are covariant
generalizations of the corresponding equations in Minkowski space-time. We find
that, after the necessary approximations have been performed, only the
left-hand side of the Boltzmann equation depends on the space-time metric. The
amplitudes in the collision term on the right--hand side are independent of the
metric, which justifies earlier calculations where this has been assumed
implicitly. At tree level, the matrix elements coincide with those computed in
vacuum. However, the loop contributions involve additional integrals over the
the distribution function.Comment: 14 pages, 5 figures, extended discussion of the constraint equations
and the solution for the spectral functio
Topoisomerase II inhibitors induce DNA damage-dependent interferon responses circumventing Ebola virus immune evasion
Ebola virus (EBOV) protein VP35 inhibits production of interferon alpha/beta (IFN) by blocking RIG-I-like receptor signaling pathways, thereby promoting virus replication and pathogenesis. A high-throughput screening assay, developed to identify compounds that either inhibit or bypass VP35 IFN-antagonist function, identified five DNA intercalators as reproducible hits from a library of bioactive compounds. Four, including doxorubicin and daunorubicin, are anthracycline antibiotics that inhibit topoisomerase II and are used clinically as chemotherapeutic drugs. These compounds were demonstrated to induce IFN responses in an ATM kinase-dependent manner and to also trigger the DNA-sensing cGAS-STING pathway of IFN induction. These compounds also suppress EBOV replication in vitro and induce IFN in the presence of IFN-antagonist proteins from multiple negative-sense RNA viruses. These findings provide new insights into signaling pathways activated by important chemotherapy drugs and identify a novel therapeutic approach for IFN induction that may be exploited to inhibit RNA virus replication
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