The Politics of Accumulation in Small?town India

Summaries Using the analytical framework of social structures of accumulation, the economic politics of local urban civil?social organisations and their impact on capital, class and the business economy is examined. Although such organisations are structured through many dimensions, notably occupation, commodity, party politics, religion, gender and locality, the most prominent single category comprises caste — and closely?related, finely?defined occupational associations. In the town's societal corporatist form of accumulation, the political, cultural and ideological hegemony of a single social group — the capitalist class — imposes itself, supported by a strong ideology based on transformations of the institution of caste. Due to the reinforcement of caste, patriarchy and the rhetoric of town unity, economic interests and ideological factors overlap in exactly the manner Gramsci thought to be the essence of civil society. Furthermore, through the caste system and through patriarchy, ideology comes to form a significant component in the local social structures of accumulation

A Theoretical Perspective on the Photochemistry of Boron-Nitrogen Lewis Adducts

Boron-Nitrogen (B-N) Lewis adducts form a versatile family of compounds with numerous applications in functional molecules. Despite the growing interest in this family of compounds for optoelectronic applications, little is currently known about their photophysics and photochemistry. Even the electronic absorption spectrum of ammonia borane, the textbook example of a B-N Lewis adduct, is unavailable. Given the versatility of the light-induced processes exhibited by these molecules, we propose in this work a detailed theoretical study of the photochemistry and photophysics of simple B-N Lewis adducts. We used advanced techniques in computational photochemistry to identify and characterize the possible photochemical pathways followed by ammonia borane, and extended this knowledge to the substituted B-N Lewis adducts pyridine-borane and pyridine-boric acid. The photochemistry observed for this series of molecules allows us to extract qualitative rules to rationalize the light-induced behavior of more complex B-N containing molecules

Adaptive upregulation of FOXD3 and resistance to PLX4032/4720-induced cell death in mutant B-RAF melanoma cells.

Melanoma cells driven by mutant v-raf murine sarcoma viral oncogene homolog B1 (B-RAF) are highly resistant to chemotherapeutic treatments. Recent phase 1 results with PLX4032/RG7204/vemurafenib, which selectively inhibits B-RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)1/2 signaling in mutant B-RAF cells, has given encouragement to this struggling field. Nearly all patients in the phase 1-3 studies saw at least some response and the overall response rates ranged from 48 and 81%. However, despite initial tumor shrinkage, most responders in the trial experienced tumor relapse over time. These findings indicate that both intrinsic and acquired resistance may affect the clinical efficacy of PLX4032. It is critical to optimize PLX4032 activity to improve response rates and understand why some patients with the B-RAF mutation do not respond. We have previously shown that the stemness factor, Forkhead box D3 (FOXD3), is upregulated following inhibition of B-RAF-MEK signaling in mutant B-RAF melanoma cells. Here, we show that upregulation of FOXD3 following treatment with PLX4032 and PLX4720 (the non-clinical tool compound for PLX4032) confers resistance to cell death. Small interfering RNA-mediated knockdown of FOXD3 significantly enhanced the cell death response after PLX4032/4720 treatment in mutant B-RAF melanoma cell lines. Additionally, upregulation of FOXD3 after PLX4720 treatment was attenuated in non-adherent conditions and correlated with enhanced cell death. Ectopic expression of FOXD3 in non-adherent cells significantly reduced cell death in response to PLX4720 treatment. Together, these data indicate that upregulation of FOXD3 is an adaptive response to RAF inhibitors that promotes a state of drug resistance

Chiral symmetry restoration, eigenvalue density of Dirac operator and axial U(1) anomaly at finite temperature

We reconsider constraints on the eigenvalue density of the Dirac operator in the chiral symmetric phase of 2 flavor QCD at finite temperature. To avoid possible ultra-violet(UV) divergences, we work on a lattice, employing the overlap Dirac operator, which ensures the exact "chiral" symmetry at finite lattice spacings. Studying multi-point correlation functions in various channels and taking their thermodynamical limit (and then taking the chiral limit), we obtain stronger constraints than those found in the previous studies: both the eigenvalue density at the origin and its first and second derivatives vanish in the chiral limit of 2 flavor QCD. In addition we show that the axial U(1) anomaly becomes invisible in susceptibilities of scalar and pseudo scalar mesons, suggesting that the 2nd order chiral phase transition with the O(4) scaling is not realized in 2 flavor QCD. Possible lattice artifacts when non-chiral lattice Dirac operator is employed are briefly discussed.Comment: 39 pages, 1 figure(2 eps files), a version published in PR

“The fur-lined rut”: telework and career ambition

In this chapter, we present a case study that explores the link between telework usage and career ambition within an organization where remote working is an embedded practice and used by a significant proportion of the workforce. First, this chapter will describe the organizational context for the case study as well as the qualitative and quantitative methods utilized. Next, qualitative and quantitative results detailing the impact of telework on career ambition will be presented. Last, a discussion of the findings, their implications for managers and suggestions as to how organizations might address the challenges associated with telework and career ambition will be presented

Destabilizing Taylor-Couette flow with suction

We consider the effect of radial fluid injection and suction on Taylor-Couette flow. Injection at the outer cylinder and suction at the inner cylinder generally results in a linearly unstable steady spiralling flow, even for cylindrical shears that are linearly stable in the absence of a radial flux. We study nonlinear aspects of the unstable motions with the energy stability method. Our results, though specialized, may have implications for drag reduction by suction, accretion in astrophysical disks, and perhaps even in the flow in the earth's polar vortex.Comment: 34 pages, 9 figure