Intralesional corticosteroid injections as first option for management of giant cell lesion of the lower jaw in a 56-year-old patient : a case report and brief literature review

Giant cell lesions of the maxillofacial region constitute a diverse group of lesions, which frequently affect the lower jaw, and are commonly detected at younger ages, in the second and third decades of life. They can be categorized as aggressive or non-aggressive lesions, mainly based on clinical behavior. Management is most commonly through surgical intervention. However, many patients consider surgery to be unfavorable due to the sacrifice of surrounding anatomic structures, potentially necessitating reconstruction procedures. Therefore, alternative modalities of conservative therapy have emerged. One method of alternative management is intralesional corticosteroid injections, which have been described with promising results. Here we report our experience with the treatment of a 56-year-old female patient, in whom a non-aggressive giant cell lesion was managed using intralesional steroid injections. This treatment resulted in total regression according to radiographic examinations

The oxidant/antioxidant status and cell death mode in oral squamous cell carcinoma

Objective. Oxidative stress and imbalance in the oxidant/antioxidant system have a critical role in carcinogenesis by affecting necrosis and apoptosis. The aim of this study is to evaluate the oxidant/antioxidant status and cell death modes in patients with oral squamous cell carcinoma (OSCC). Materials and methods. Twenty-nine patients with OSCC and 29 control subjects were included in the study. The levels of malondialdehyde (MDA), advanced oxidation protein products (AOPP) and ferric reducing antioxidant power (FRAP) were determined in plasma samples of all subjects. The necrotic and apoptotic cell death modes were evaluated with M65 ELISA and M30 ELISA, respectively. Results. MDA and AOPP values as oxidative stress markers were higher in patients with OSCC than in the control group. FRAP values evaluating plasma antioxidant status increased in OSCC patients. M65 and M30 levels indicating necrosis and apoptosis were significantly higher in OSCC patients compared to controls. There were significant correlations between MDA, AOPP and FRAP; M65 and M30 values. Conclusions. The elevated levels of oxidative stress markers together with the increase of antioxidant capacity and the presence of a strong correlation between MDA, AOPP and FRAP suggest an activation of antioxidant defense against accentuated oxidative stress determined in OSCC. Enhanced oxidation of lipids and proteins may cause decomposition of cell membranes with subsequent leakage of cytoskeletal cytokeratins as CK18 and caspase-cleaved CK18 (evaluated as M65 and M30, respectively) in the circulation, suggesting that both cell death modes are affected in OSCC

CHANGES IN THE LEVELS OF SALIVARY SODIUM AND POTASSIUM IN PATIENTS WITH ESSENTIAL HYPERTENSION

It has been known that the metabolism of some elements in the body is affected by essential hypertension. However the interaction between essential hypertension and electrolytes in blood and urine samples has been investigated in several studies, this interaction in saliva still requires further studies. The aim of this study is to examine the changes in concentration of some trace elements like sodium, potassium of saliva in patients who have essential hypertension. It is also aimed to search if laboratory findings associated with salivary elements have diagnostic importance. 20 patients with essential hypertension, 20 patients undergoing antihypertensive treatment for 10 years and 20 normotensive patients were included in this study. Mixed saliva secretion samples from all patients were collected for determining concentrations of sodium and potassium. In addition to conventional laboratory techniques, neutron activation analysis and multi-element discriminating techniques were used. As a result sodium levels in patients with hypertension, undergoing antihypertensive treatment and in normotensive patients were found higher than the levels in patients with hypertension who do not undergo any treatment. Potassium level in first two group patients was found statistically less than the last group

Recurrent Cherubism in an Adult Patient

Cherubism is an uncommon, nonneoplastic, fibro-osseous disorder of the jaws in childhood and adolescence. It affects the jaw bones by deforming the cortical shell. Clinical features include progressive painless and mostly bilateral expansion of the mandible and/or maxilla. Because fibrous connective tissue replaces osseous tissue, radiographic features generally include expansile osteolytic lesions and a ground-glass appearance. Several treatment protocols for cherubism have been recommended in the literature; however, despite surgical curettage treatment, recurrences may occur