Chapter 4 Hopi Kachinas: A Life Force

“Everything has an essence or life force, and humans must interact with these or fail to survive.” It is not known where the Kachina Cult originated, but some evidence points to a Meso-American origin, brought possibly with the clans which migrated from north to south and north again. There are a few archaeological hints which indicate that there was a viable Kachina Cult by the time the Hopi settled at the center of their world in 1100. The Kachina Cult is shared with all the other Pueblo peoples who live to the east, from Zuni to Taos and formerly Pecos on the eastern border. Each of these groups have their own substantive perceptions and practices of the Kachina Cult. The central theme of the Kachina Cult is the presence of life in all objects that fill the universe. Everything has an essence or a life force, and humans must interact with these or fail to survive. It is much easier to interact with impersonal forces if they are given life forms and if patterns of reciprocity and mutual obligations are established. It is these visualizations, these personifications that are the kachinas. To understand the relationships that exist between humans and kachinas, a tentative model of their cosmos can be constructed. It consists of either two states of being occupying the same space or as two halves of a sphere. In the spherical model, half of the universe is an underworld or the world of the supernatural, and the other half is the normal, real world. The sun circles endlessly beyond the immediate control of either hemisphere yet interacts with both. The contents of one hemisphere are the mirror image of the other, but where one half is composed of objects and beings of solidity and mass, the other is an ethereal, imponderable world of cloud-like beings. Evidence for this world lies in the clouds that rise above mountain peaks, the smoke from burning objects, the fog that arises from water on a cold morning, steam from food, the breath of living beings that leaves them when they die and passes into the other world. This is the world of kachinas, a place where the bodies of the dead go to continue interacting with their universe, but in a new form—alter egos of their former life. Kachinas are the life forces of the cosmos that surround the Hopis on either plane, living or dead. Each of these forces, regardless of their physical appearance in the normal world, is a pseudo-morphic human in the supernatural world. These beings possess attributes that humans do not have, for kachinas can make it rain, cause the crops to grow well, or bring a multitude of other benefits if they are properly treated. They are not the ancestors of the Hopi but beings with whom all Hopi have interacted for mutual benefit through the centuries. The appearance of each kachina is dictated by its role as visually interpreted by Hopis and distilled through time to a traditional form. The more powerful the potential of the kachina, the more abstract are its features and symbols. This second form of the kachinas may be seen when the men who impersonate these spirits appear in ceremonies or dances in the village plazas or kivas from late December to late July as called for by the complex Hopi ceremonial calendar. It is believed that by donning mask, costume, and paint, the impersonator becomes imbued with the kachina spirit, that for the time of the dance kachina and man are one

Stability and response of polygenic traits to stabilizing selection and mutation

When polygenic traits are under stabilizing selection, many different combinations of alleles allow close adaptation to the optimum. If alleles have equal effects, all combinations that result in the same deviation from the optimum are equivalent. Furthermore, the genetic variance that is maintained by mutation-selection balance is $2 \mu/S$ per locus, where $\mu$ is the mutation rate and $S$ the strength of stabilizing selection. In reality, alleles vary in their effects, making the fitness landscape asymmetric, and complicating analysis of the equilibria. We show that that the resulting genetic variance depends on the fraction of alleles near fixation, which contribute by $2 \mu/S$, and on the total mutational effects of alleles that are at intermediate frequency. The interplay between stabilizing selection and mutation leads to a sharp transition: alleles with effects smaller than a threshold value of $2\sqrt{\mu / S}$ remain polymorphic, whereas those with larger effects are fixed. The genetic load in equilibrium is less than for traits of equal effects, and the fitness equilibria are more similar. We find that if the optimum is displaced, alleles with effects close to the threshold value sweep first, and their rate of increase is bounded by $\sqrt{\mu S}$. Long term response leads in general to well-adapted traits, unlike the case of equal effects that often end up at a sub-optimal fitness peak. However, the particular peaks to which the populations converge are extremely sensitive to the initial states, and to the speed of the shift of the optimum trait value.Comment: Accepted in Genetic

The glia response after peripheral nerve injury: A comparison between Schwann cells and olfactory ensheathing cells and their uses for neural regenerative therapies

The peripheral nervous system (PNS) exhibits a much larger capacity for regeneration than the central nervous system (CNS). One reason for this difference is the difference in glial cell types between the two systems. PNS glia respond rapidly to nerve injury by clearing debris from the injury site, supplying essential growth factors and providing structural support; all of which enhances neuronal regeneration. Thus, transplantation of glial cells from the PNS is a very promising therapy for injuries to both the PNS and the CNS. There are two key types of PNS glia: olfactory ensheathing cells (OECs), which populate the olfactory nerve, and Schwann cells (SCs), which are present in the rest of the PNS. These two glial types share many similar morphological and functional characteristics but also exhibit key differences. The olfactory nerve is constantly turning over throughout life, which means OECs are continuously stimulating neural regeneration, whilst SCs only promote regeneration after direct injury to the PNS. This review presents a comparison between these two PNS systems in respect to normal physiology, developmental anatomy, glial functions and their responses to injury. A thorough understanding of the mechanisms and differences between the two systems is crucial for the development of future therapies using transplantation of peripheral glia to treat neural injuries and/or disease.Griffith Health, School of Nursing and MidwiferyFull Tex

An evaluation of a multi-site community pharmacy based chronic obstructive pulmonary disease support service

Background Chronic obstructive pulmonary disease (COPD) is a progressive chronic condition which can be effectively managed by smoking cessation, optimising prescribed therapy and providing treatment to prevent chest infections from causing hospitalisation. The government agenda in the UK is for community pharmacists to become involved in chronic disease management and COPD is one area where they are ideally located to provide a comprehensive service. Objective To evaluate the effect of a community pharmacy based COPD service on patient outcomes. Method Patients in one UK location were recruited over a 3 month period to receive a community pharmacy based COPD support service consisting of signposting to or provision of smoking cessation service, therapy optimisation, and recommendation to obtain a rescue pack containing steroid and antibiotic to prevent hospitalisation as a result of chest infection. Data was collected over a six month period for all recruited patients. Appropriate clinical outcomes, patient reported medication adherence, quality of life and NHS resource utilisation were measured. Key findings 306 patients accessed the service and full data to enable comparison before and after was available for 137. Significant improvements in patient reported adherence, utilisation of rescue packs, quality of life and a reduction in routine GP visits were identified. The intervention cost was estimated to be off-set by reductions in the use of other NHS services (GP and A&E visits and hospital admissions). Conclusion Results suggest that the service improved patient medicine taking behaviours and that it was cost-effective

The contribution of statistical physics to evolutionary biology

Evolutionary biology shares many concepts with statistical physics: both deal with populations, whether of molecules or organisms, and both seek to simplify evolution in very many dimensions. Often, methodologies have undergone parallel and independent development, as with stochastic methods in population genetics. We discuss aspects of population genetics that have embraced methods from physics: amongst others, non-equilibrium statistical mechanics, travelling waves, and Monte-Carlo methods have been used to study polygenic evolution, rates of adaptation, and range expansions. These applications indicate that evolutionary biology can further benefit from interactions with other areas of statistical physics, for example, by following the distribution of paths taken by a population through time.Comment: 18 pages, 3 figures, glossary. Accepted in Trend in Ecology and Evolution (to appear in print in August 2011

Singular solutions of the diffusion equation of population genetics

The forward diffusion equation for gene frequency dynamics is solved subject to the condition that the total probability is conserved at all times. This can lead to solutions developing singular spikes (Dirac delta functions) at the gene frequencies 0 and 1. When such spikes appear in solutions they signal gene loss or gene fixation, with the "weight" associated with the spikes corresponding to the probability of loss or fixation. The forward diffusion equation is thus solved for all gene frequencies, namely the absorbing frequencies of 0 and 1 along with the continuous range of gene frequencies on the interval (0; 1) that excludes the frequencies 0 and 1. Previously, the probabilities if the absorbing frequencies 0 and 1 were found by appeal to the backward diffusion equation, while those in the continuous range (0; 1) were found from the forward diffusion equation. Our uni fied approach does not require two separate equations for a complete dynamical treatment of all gene frequencies within a diffusion approximation framework. For cases involving mutation, migration and selection, it is shown that a property of the deterministic part of gene frequency dynamics determines when fixation and loss can occur. It is also shown how solution of the forward equation, at long times, leads to the standard result for the fixation probability

Guard Sets in Tor using AS Relationships

The mechanism for picking guards in Tor suffers from security problems like guard fingerprinting and from performance issues. To address these issues, Hayes and Danezis proposed the use of guard sets, in which the Tor system groups all guards into sets, and each client picks one of these sets and uses its guards. Unfortunately, guard sets frequently need nodes added or they are broken up due to fluctuations in network bandwidth. In this paper, we first show that these breakups create opportunities for malicious guards to join many guard sets by merely tuning the bandwidth they make available to Tor, and this greatly increases the number of clients exposed to malicious guards. To address this problem, we propose a new method for forming guard sets based on Internet location. We construct a hierarchy that keeps clients and guards together more reliably and prevents guards from easily joining arbitrary guard sets. This approach also has the advantage of confining an attacker with access to limited locations on the Internet to a small number of guard sets. We simulate this guard set design using historical Tor data in the presence of both relay-level adversaries and network-level adversaries, and we find that our approach is good at confining the adversary into few guard sets, thus limiting the impact of attacks

Near-periodic substitution and the genetic variance induced by environmental change

We investigate a model that describes the evolution of a diploid sexual population in a changing environment. Individuals have discrete generations and are subject to selection on the phenotypic value of a quantitative trait, which is controlled by a finite number of bialleic loci. Environmental change is taken to lead to a uniformly changing optimal phenotypic value. The population continually adapts to the changing environment, by allelic substitution, at the loci controlling the trait. We investigate the detailed interrelation between the process of allelic substitution and the adaptation and variation of the population, via infinite population calculations and finite population simulations. We find a simple relation between the substitution rate and the rate of change of the optimal phenotypic value