Country report : Italy

ITHACA - Integration, Transnational Mobility and Human, Social and Economic Capital Transfer

Geometry in early years: sowing seeds for a mathematical definition of squares and rectangles

In early years schooling it is becoming common to propose activities that involve moving along paths, or programming robots to do so. In order to promote continuity towards the introduction of geometry in primary school, we developed a long-term teaching experiment (with 15 sessions) carried out over four months in a first grade classroom in northern Italy. Students were asked to program a robot to move along paths, to pretend to act as robots and to represent the sequence of commands and the resulting paths. In particular, in this teaching experiment, an overarching mathematical aim was to sow the seeds for a mathematical definition of rectangles that includes squares. Within the paradigm of semiotic mediation, we intended to foster the students’ transition from a dynamic perception of paths to seeing paths also as static wholes, boundaries of figures with sets of geometric characteristics. The students’ situated productions were collected and analysed together with the specific actions of the adults involved, aimed at fostering processes of semiotic mediation. In this paper we analyse the development of the situated texts produced by the students in relation to the pivot signs that were the beginnings of an inclusive definition of rectangles

Using pivot signs to reach an inclusive definition of squares and rectangles

We present some fragments of a teaching experiment realized in a first grade classroom, to sow the seeds for a mathematical definition of rectangles that includes squares. Within the paradigm of semiotic mediation, we studied the emergence of pivot signs, which were exploited by the teacher to pave the way towards an inclusive definition of rectangles and squares. This was done to favor overcoming children's spontaneous distinction of these figures into distinct categories, reinforced by everyday language. The experiment is an example of an approach towards the theoretical dimension of mathematics in early childhood

Business performance analytics: exploring the potential for performance management systems

Business Performance Analytics (BPA) entails the systematic use of data and analytical methods (mathematical, econometric and statistical) for performance measurement and management. Although potentially overcoming some traditional diagnostic issues related to Performance Management Systems (PMS), such as information overload, absence of cause-effect relationships, lack of a holistic view of the organisation, research in the field is still in its infancy. A comprehensive model for operationalising analytics for diagnostic and interactive PMS is still lacking. Adopting an action research approach, this paper addresses this gap and develops a five-step framework applied to a company operating in the construction industry. The results show that in addition to encouraging dialogue, BPA can contribute to identifying critical performance variables, potential sources of risk and related interdependencies. A number of critical issues in implementing data-based approaches are also highlighted, including data quality, organisational competences and cultural shifts

Simultaneous control of DNA and RNA processing efficiency using a nucleic acid calibration set.

PCR-based detection techniques enables reliable and sensitive nucleic acid target detection. However, quantitative determination methods often fail to control for the efficiency of nucleic acid extraction, reverse transcription, and PCR amplification. This problem is even more prominent when working with clinical samples due to target sequence loss during nucleic acid processing or the co-purification of PCR inhibitors (1,2). Handling processes are often assumed to approach 100% efficiency in the laboratory, even if practical experience shows that this efficiency can be much lower. This inability to ensure accuracy can lead to significant error in uncalibrated DNA sample quantitation. The additional need for reverse transcription of RNA may further increase the quantitative error rate, as yet another enzymatic process is involved. Nucleic acid controls have been developed based upon known sequences to calibrate either DNA or RNA handling; DNA calibrators have been used to control for the amplification of target sequences using realtime PCR methods (3–8), while RNA calibrators have been developed to test reverse transcription and amplification efficiencies (9–11). A nonpathogenic viral particle carrying a sequence for use as an external positive control of extraction and amplification has also been described (12). Unfortunately, most of the established processing controls are only suitable for limited applications (i.e., either DNA or RNA detection). Cross-contamination of biological samples or minute detection from natural sources reveals the need for completely synthetic sequences, with no homology to sequences in the nucleic acid databases. It is, therefore, beneficial to design an internal, synthetic calibration system that can control for both DNA and RNA processing steps in a single tube. This set includes both RNA and DNA targets with identical primer binding sites and, thus, primer binding efficiency, but easily distinguishable sequence characteristics, allowing for simultaneous detection, quantitation, and calibration of nucleic acid processing efficiency. A 150-bp randomly generated nucleic acid sequence was developed for use as a short control (SC). A GCrich 75-bp sequence was inserted in the middle of the 150-bp sequence to generate a 225-bp sequence, long control (LC). Besides size, the two sequences were designed to have easily distinguishable probe binding sites with a predicted product melting temperature difference of 4°C. Calibrator sequences have been published as GenBank® accession nos. EF143258 (DNA control, LC) and EF143257 (RNA control, SC). Simultaneous control of DNA and RNA processing efficiency using a nucleic acid calibration se

Buone pratiche didattiche per prevenire falsi positivi nelle diagnosi di discalculia: il progetto PerContare

To contrast the phenomenon of false positives in the diagnoses of dyscalculia in Italy, among 3rd grade children, a 3-year project (2011-2014), built upon a collaboration between psychologists and mathematics educators, was carried out. Within the project specific teaching strategies for preventing and addressing learning difficulties in arithmetic arising at the beginning of primary school were designed and tested in schools nation wide. This paper presents the project's background and the theoretical foundations of the didactical material designed, providing also some examples. In particular, prototypical examples will show how the activities, grounded within a kinesthetic-tactile and visual-spatial approach, are designed to lead to students' interiorization of part-whole relations, and to their thinking about multiplication through structured diagrams. Qualitative data confirming effectiveness of the proposed didactical strategies will also be discussed.Comment: in Italia

Comparative Study of Immunogenicity of Split, Intradermal and MF59-adjuvanted Influenza Vaccines in Elderly Institutionalized Subjects

Abstract The reduced immunogenicity and effectiveness of influenza vaccines in subjects presenting high risk of influenza-related complications, hospitalization and death, led the innovative drive to search for new strategies to implement the immune response elicited by influenza vaccines including addition of adjuvants, and use of alternative routes of antigen delivery.In this study we evaluated and compared the immune antibody response induced in 252 elderly volunteers living in nursing homes after immunization with three different 2012-2013 seasonal trivalent inactivated influenza vaccines: a conventional split vaccine (n=26), and two potentiated vaccines (a subunit vaccine adjuvanted with MF59 (n=137) or a split vaccine administered intradermally (n=89)), specially licensed for elderly people. Haemagglutination inhibiting (HI) antibody titers were assessed in blood samples collected before and one month after vaccination.The results were evaluated as increase in HI titers found comparing pre- and post-vaccination sera and according to the Committee for Medicinal Products for Human Use (CHMP) criteria for approval of influenza vaccines in the elderly. Significant antibody increases and fulfillment of all the three CHMP requirements were observed against A/H3N2 and B antigens following immunization with the two potentiated vaccines. After immunization with conventional vaccine responses were lower against A/H3N2 and equivalent against the B antigen. The two potentiated vaccines induced significant antibody increases against A/H1N1 antigen, however, only one of the CHMP criteria was reached. The HI antibody increases after conventional vaccine were significant only for the geometric mean titer and none of the CHMP criteria was fulfilled. The antibody responses induced by the two potentiated vaccines against the three vaccine antigens wereequivalent although post-vaccination titers against the B antigen tended to be higher in subjects vaccinated with intradermal vaccine than in individuals receiving MF59-adjuvanted vaccine. In conclusion the use of MF59 adjuvant and intradermal vaccination appear to be appropriate strategies to address the challenge of declining immune response in the elderly after influenza vaccination

Exploring the links between enhancing regular pathways and discouraging irregular migration : a discussion paper to inform future policy deliberations

The relationship between discouraging irregular migration through enforcement and encouraging regular migration flows is not straightforward. Relevant studies have highlighted complex dynamics. While stricter controls through both “fencing” (border controls) and “gatekeeping” (visa restrictions) policies appear to slow irregular migration, they also tend to change its course, leading migrants to try their luck through alternative irregular channels. Understanding migrant decision making as well as the contexts in which potential migrants make decisions is critically important but often misunderstood or ignored in policy deliberations. This discussion paper reviews a number of policy ideas that could lead to better management of regular migration while discouraging irregular flows as well as decision making contexts: Enhanced regional mobility regimes that allow for relatively seamless mobility within a set of countries, coupled with specific rights and obligations for workers and employers; Bilateral mobility schemes between a country of origin and a country of destination that respond to specific labour market dynamics; Sponsorship schemes that may facilitate entry and integration of the migrant and her/his family at destination; Humanitarian corridors that aim at preventing vulnerable migrants (including those who have become stranded) from undertaking irregular migration, with a view of arriving in a safe third country. New ideas discussed include Temporary Migration Partnerships; Skills and Mobility Partnerships; a Human Development Visa Scheme

Digital Twins applied to the implementation of Safe-by-Design strategies in nano-processes for the reduction of airborne emission and occupational exposure to nano-forms

Digital Twins (DTs) are one of the most promising enabling technologies for the deployment of the factory of the future and the Industry 4.0 framework. DTs could be labelled as an inherently Safe-by-Design (SbD) strategy and can be applied at different stages in the life cycle of a process. The EU-funded project ASINA has the ambition to promote coherent, applicable and scientifically sound SbD nano-practices. In particular, in the field of nanomanufacturing, ASINA intends to deliver innovative SbD solutions applied to process (P-SbD). In this context, ASINA will investigate the use of DTs as a disruptive digital technology for the prevention, prediction and control of nano-forms airborne emission and worker exposure. This paper introduces the concept of DT in the field of nano-processes SbD and outlines the preliminary architecture of ASINA-DT, that will be developed and implemented by ASINA in one industrial scenario.The project ASINA received funding from the European Union’s Horizon 2020 research and innovation programme, under grant agreement Nº 862444. This paper reflects only the authors’ views, and the Commission is not responsible for any use that may be made of the information contained therein