Analysis of a Precambrian resonance-stabilized day length

During the Precambrian era, Earth's decelerating rotation would have passed a 21-hour period that would have been resonant with the semidiurnal atmospheric thermal tide. Near this point, the atmospheric torque would have been maximized, being comparable in magnitude but opposite in direction to the lunar torque, halting Earth's rotational deceleration, maintaining a constant day length, as detailed by Zahnle and Walker (1987). We develop a computational model to determine necessary conditions for formation and breakage of this resonant effect. Our simulations show the resonance to be resilient to atmospheric thermal noise but suggest a sudden atmospheric temperature increase like the deglaciation period following a possible "snowball Earth" near the end of the Precambrian would break this resonance; the Marinoan and Sturtian glaciations seem the most likely candidates for this event. Our model provides a simulated day length over time that resembles existing paleorotational data, though further data is needed to verify this hypothesis.Comment: 7 pages, 5 figures. Accepted for publication in Geophysical Research Letters on 10 May 201

Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates

Nonhomologous end-joining (NHEJ) pathways repair DNA double-strand breaks (DSBs) in eukaryotes and many prokaryotes, although it is not reported to operate in the third domain of life, archaea. Here, we describe a complete NHEJ complex, consisting of DNA ligase (Lig), polymerase (Pol), phosphoesterase (PE), and Ku from a mesophillic archaeon, Methanocella paludicola (Mpa). Mpa Lig has limited DNA nick-sealing activity but is efficient in ligating nicks containing a 3′ ribonucleotide. Mpa Pol preferentially incorporates nucleoside triphosphates onto a DNA primer strand, filling DNA gaps in annealed breaks. Mpa PE sequentially removes 3′ phosphates and ribonucleotides from primer strands, leaving a ligatable terminal 3′ monoribonucleotide. These proteins, together with the DNA end-binding protein Ku, form a functional NHEJ break-repair apparatus that is highly homologous to the bacterial complex. Although the major roles of Pol and Lig in break repair have been reported, PE’s function in NHEJ has remained obscure. We establish that PE is required for ribonucleolytic resection of RNA intermediates at annealed DSBs. Polymerase-catalyzed strand-displacement synthesis on DNA gaps can result in the formation of nonligatable NHEJ intermediates. The function of PE in NHEJ repair is to detect and remove inappropriately incorporated ribonucleotides or phosphates from 3′ ends of annealed DSBs to configure the termini for ligation. Thus, PE prevents the accumulation of abortive genotoxic DNA intermediates arising from strand displacement synthesis that otherwise would be refractory to repair

The NASA supercritical-wing technology

A number of high aspect ratio supercritical wings in combination with a representative wide body type fuselage were tested in the Langley 8 foot transonic pressure tunnel. The wing parameters investigated include aspect ratio, sweep, thickness to chord ratio, and camber. Subsequent to these initial series of tests, a particular wing configuration was selected for further study and development. Tests on the selected wing involved the incorporation of a larger inboard trailing edge extension, an inboard leading edge extension, and flow through nacelles. Range factors for the various supercritical wing configurations are compared with those for a reference wide body transport configuration

Randomized Smoothing for Stochastic Optimization

We analyze convergence rates of stochastic optimization procedures for non-smooth convex optimization problems. By combining randomized smoothing techniques with accelerated gradient methods, we obtain convergence rates of stochastic optimization procedures, both in expectation and with high probability, that have optimal dependence on the variance of the gradient estimates. To the best of our knowledge, these are the first variance-based rates for non-smooth optimization. We give several applications of our results to statistical estimation problems, and provide experimental results that demonstrate the effectiveness of the proposed algorithms. We also describe how a combination of our algorithm with recent work on decentralized optimization yields a distributed stochastic optimization algorithm that is order-optimal.Comment: 39 pages, 3 figure

Design and development of techniques for fabrication of cryogenic tank support structures for long term storage in space flights Final report

Design optimization and fabrication of conical support structure for cryogenic tank in long duration space fligh

The Effect of Recombinant Bovine Somatotropin on Patterns of Milk Production, Lactational Milk Estimates and Net Farm Income

Bovine somatoropin (bST) alters total milk production and production patterns in dairy cows and understanding the economic benefits of bST for the dairy producer are critical. Holstein cows (n = 555) from four Michigan dairy farms were randomly assigned as untreated controls or to receive 500 mg of bovine somatotropin (PosilacR) administered every 14 days beginning at 63 to 69 days of lactation and continuing until approximately 21 days prior to the end of lactation or until the animal was removed from the herd. Average peak milk production was 50.8 kg / day and occurred at an average of 113 9 days of lactation for bST-treated cows while average peak production was 48.9 kg / day occurring at an average of 86.4 days of lactation for control cows; both parameters were significantly greater for bST-treated cows compared to controls. Study cows treated with bST were significantly more persistent in lactation (7% greater lactational persistency) compared to control cows. All DHIA estimates and actual milk produced were not significantly different between the study treatment groups for any of the four comparisons made (first, second, third monthly tests after bST treatment initiation and final (305-day) DHIA production estimates); however, the accuracy of DHIA production estimates was significantly affect by the amount of time elapsed since bST but became non-significant by the third DHIA test date. The use of bST changed NFI for each of the four study farms by $96.21,$3.57, $78.71 and ($7.15) per bST-treated cow, respectively during the trial period (from 63 to 305 days of lactation). The overall average change in NFI attributable to bST was $43.01 per bST-treated cow. 2 Profitability of bST use was observed to be quite variable between farms studied because many factors were found to affect the change in NFI per cow resulting from bST use; the level of production response and the price received for milk had the largest effects on the change in NFI associated with bST use; by contrast, price paid for bST itself and feed had only minimal effects on bST-associated profitability. Diseases that may be associated with bST may reduce the profitability of this product and need to be considered as a cost of bST use if present.bovine somatotropin, dairy, net farm income, Farm Management, Livestock Production/Industries, Productivity Analysis, Research and Development/Tech Change/Emerging,

Site dependent factors affecting the economic feasibility of solar powered absorption cooling

A procedure was developed to evaluate the cost effectiveness of combining an absorption cycle chiller with a solar energy system. A basic assumption of the procedure is that a solar energy system exists for meeting the heating load of the building, and that the building must be cooled. The decision to be made is to either cool the building with a conventional vapor compression cycle chiller or to use the existing solar energy system to provide a heat input to the absorption chiller. Two methods of meeting the cooling load not supplied by solar energy were considered. In the first method, heat is supplied to the absorption chiller by a boiler using fossil fuel. In the second method, the load not met by solar energy is net by a conventional vapor compression chiller. In addition, the procedure can consider waste heat as another form of auxiliary energy. Commercial applications of solar cooling with an absorption chiller were found to be more cost effective than the residential applications. In general, it was found that the larger the chiller, the more economically feasible it would be. Also, it was found that a conventional vapor compression chiller is a viable alternative for the auxiliary cooling source, especially for the larger chillers. The results of the analysis gives a relative rating of the sites considered as to their economic feasibility of solar cooling