Real-world experience of nintedanib for progressive fibrosing interstitial lung disease in the UK

This is the final version. Available on open access from the European Respiratory Society via the DOI in this recordBackground Nintedanib slows progression of lung function decline in patients with progressive fibrosing (PF) interstitial lung disease (ILD) and was recommended for this indication within the United Kingdom (UK) National Health Service in Scotland in June 2021 and in England, Wales and Northern Ireland in November 2021. To date, there has been no national evaluation of the use of nintedanib for PF-ILD in a real-world setting. Methods 26 UK centres were invited to take part in a national service evaluation between 17 November 2021 and 30 September 2022. Summary data regarding underlying diagnosis, pulmonary function tests, diagnostic criteria, radiological appearance, concurrent immunosuppressive therapy and drug tolerability were collected via electronic survey. Results 24 UK prescribing centres responded to the service evaluation invitation. Between 17 November 2021 and 30 September 2022, 1120 patients received a multidisciplinary team recommendation to commence nintedanib for PF-ILD. The most common underlying diagnoses were hypersensitivity pneumonitis (298 out of 1120, 26.6%), connective tissue disease associated ILD (197 out of 1120, 17.6%), rheumatoid arthritis associated ILD (180 out of 1120, 16.0%), idiopathic nonspecific interstitial pneumonia (125 out of 1120, 11.1%) and unclassifiable ILD (100 out of 1120, 8.9%). Of these, 54.4% (609 out of 1120) were receiving concomitant corticosteroids, 355 (31.7%) out of 1120 were receiving concomitant mycophenolate mofetil and 340 (30.3%) out of 1120 were receiving another immunosuppressive/modulatory therapy. Radiological progression of ILD combined with worsening respiratory symptoms was the most common reason for the diagnosis of PF-ILD. Conclusion We have demonstrated the use of nintedanib for the treatment of PF-ILD across a broad range of underlying conditions. Nintedanib is frequently co-prescribed alongside immunosuppressive and immunomodulatory therapy. The use of nintedanib for the treatment of PF-ILD has demonstrated acceptable tolerability in a real-world setting.Engineering and Physical Sciences Research Council (EPSRC

Collins and Sivers asymmetries in muonproduction of pions and kaons off transversely polarised protons

Measurements of the Collins and Sivers asymmetries for charged pions and charged and neutral kaons produced in semi-inclusive deep-inelastic scattering of high energy muons off transversely polarised protons are presented. The results were obtained using all the available COMPASS proton data, which were taken in the years 2007 and 2010. The Collins asymmetries exhibit in the valence region a non-zero signal for pions and there are hints of non-zero signal also for kaons. The Sivers asymmetries are found to be positive for positive pions and kaons and compatible with zero otherwise. © 2015

Real-world data from 24 UK centres for the use of nintedanib for progressive fibrosing interstitial lung disease

This is the author accepted manuscript. The final version is available from the European Respiratory Society via the DOI in this record

Real-world experience of nintedanib for progressive fibrosing interstitial lung disease in the UK

\ua9 The authors 2024.Background Nintedanib slows progression of lung function decline in patients with progressive fibrosing (PF) interstitial lung disease (ILD) and was recommended for this indication within the United Kingdom (UK) National Health Service in Scotland in June 2021 and in England, Wales and Northern Ireland in November 2021. To date, there has been no national evaluation of the use of nintedanib for PF-ILD in a real-world setting. Methods 26 UK centres were invited to take part in a national service evaluation between 17 November 2021 and 30 September 2022. Summary data regarding underlying diagnosis, pulmonary function tests, diagnostic criteria, radiological appearance, concurrent immunosuppressive therapy and drug tolerability were collected via electronic survey. Results 24 UK prescribing centres responded to the service evaluation invitation. Between 17 November 2021 and 30 September 2022, 1120 patients received a multidisciplinary team recommendation to commence nintedanib for PF-ILD. The most common underlying diagnoses were hypersensitivity pneumonitis (298 out of 1120, 26.6%), connective tissue disease associated ILD (197 out of 1120, 17.6%), rheumatoid arthritis associated ILD (180 out of 1120, 16.0%), idiopathic nonspecific interstitial pneumonia (125 out of 1120, 11.1%) and unclassifiable ILD (100 out of 1120, 8.9%). Of these, 54.4% (609 out of 1120) were receiving concomitant corticosteroids, 355 (31.7%) out of 1120 were receiving concomitant mycophenolate mofetil and 340 (30.3%) out of 1120 were receiving another immunosuppressive/ modulatory therapy. Radiological progression of ILD combined with worsening respiratory symptoms was the most common reason for the diagnosis of PF-ILD. Conclusion We have demonstrated the use of nintedanib for the treatment of PF-ILD across a broad range of underlying conditions. Nintedanib is frequently co-prescribed alongside immunosuppressive and immunomodulatory therapy. The use of nintedanib for the treatment of PF-ILD has demonstrated acceptable tolerability in a real-world setting

Piezoelectric, dielectric and pyroelectric properties of 0-3 ceramic-polymer composites

The circular samples of composites were made from PZT ceramic grains dispersed in polymers (epoxy or rubber). Pressure dependencies of the hydrostatic piezoelectric coefficient dh and permittivity ε were measured in the range up to 60 MPa. The hydrostatic strain coefficient dh, the hydrostatic voltage coefficient gh and figure of merit dh·gh were determined using the static method. The pressure dependence of the hydrostatic coefficients was measured for several successive cycles. Experimental dependence of the charge on pressure and temperature was fitted by multi parameter function. The pressure and temperature dependencies of the hydrostatic dh and pyroelectric p3 coefficients were determined. It was found that the hydrostatic strain coefficient dh and hydrostatic voltage coefficient gh decreased and pyroelectric coefficient p3 increased with pressure at constant temperature.DFG [1102]; ICTP programme for Training and Research in Italian Laboratories (TRIL); German Bundesministerium fur Bildung und Forschung; Czech Republic MEYS Grants [ME492, LA242]; SAIL (CSR), Govt. of India; CERN-RFBR Grants [08-02-91009, 12-02-91500]; Portuguese FCT - Fundacao para a Ciencia e Tecnologia [CERN/FP/109323/2009, CERN/FP/116376/2010, CERN/FP/123600/2011]; MEXT; JSPS [18002006, 20540299, 18540281]; Daiko Foundation; Yamada Foundation; DFG cluster of excellence 'Origin and Structure of the Universe'; EU FP7 (HadronPhysics3) [283286]; Israel Science Foundation; Polish NCN Grant [DEC-2011/01/M/ST2/02350

Odd and even partial waves of eta pi(-) and eta 'pi(-) in pi(-) p -> eta(('))pi(-)p at 191 GeV/c

Exclusive production of eta pi(-) and eta'pi(-) in has been studied with a 191 GeV/c pi(-) beam impinging on a hydrogen target at COMPASS (CERN). Partial-wave analyses reveal different odd/even angular momentum (L) characteristics in the inspected invariant mass range up to 3 GeV/c(2). A striking similarity between the two systems is observed for the L = 2, 4, 6 intensities (scaled by kinematical factors) and the relative phases. The known resonances a(2)(1320) and a(4)(2040) are in line with this similarity. In contrast, a strong enhancement of eta'pi(-) over eta pi(-) is found for the L = 1, 3, 5 waves, which carry non-qq quantum numbers. The L = 1 intensity peaks at 1.7 GeV/c(2) in in and at 1.4 GeV/c(2) in eta pi(-), the corresponding phase motions with respect to L = 2 are different. (C) 2014 The Authors. Published by Elsevier B.V.DFG [1102]; German Bundesministerium fur Bildung und Forschung; Czech Republic MEYS [ME492, LA242]; SAIL (CSR), Govt. of India; CERN-RFBR [08-02-91009, 12-02-91500]; Portuguese FCT - Fundacao para a Ciencia e Tecnologia [CERN/FP/109323/2009, CERN/FP/116376/2010, CERN/FP/123600/2011]; MEXT; JSPS [18002006, 20540299, 18540281]; Daiko Foundation; Yamada Foundation; DFG; EU [283286]; Israel Science Foundation; Polish NCN [DEC-2011/01/M/ST2/02350

Search for exclusive photoproduction of Z(c)(+/-) (3900) at COMPASS

A search for the exclusive production of the Z(c)(+/-)(3900) hadron by virtual photons has been performed in the channel Z(c)(+/-)(3900). J/Psi pi(+/-). The data cover the range from 7GeV to 19GeV in the centre-of- mass energy of the photon-nucleon system. The full set of the COMPASS data set collected with a muon beam between 2002 and 2011 has been used. An upper limit for the ratio BR(Z(c)(+/-)(3900)-> J/Psi pi(+/-)) x sigma(gamma N) -> Z(c)(+/-)(3900) N/sigma gamma N -> J/Psi N 3.7 x10(-3) has been established at the confidence level of90%. (C) 2015 The Authors. Published by Elsevier B.V.CERN managemen

Spin alignment and violation of the OZI rule in exclusive omega and phi production in pp collisions

Exclusive production of the isoscalar vector mesons omega and phi is measured with a 190 GeV/c proton beam impinging on a liquid hydrogen target. Cross section ratios are determined in three intervals of the Feynman variable x(F) of the fast proton. A significant violation of the OZI rule is found, confirming earlier findings. Its kinematic dependence on xF and on the invariant mass M-pV of the system formed by fast proton p(fast) and vector meson V is discussed in terms of diffractive production of p(fast) V resonances in competition with central production. The measurement of the spin density matrix element rho(00) of the vector mesons in different selected reference frames provides another handle to distinguish the contributions of these two major reaction types. Again, dependences of the alignment on x(F) and on M-pV are found. Most of the observations can be traced back to the existence of several excited baryon states contributing to omega production which are absent in the case of the phi meson. Removing the low-mass M-pV resonant region, the OZI rule is found to be violated by a factor of eight, independently of x(F). (C) 2014 CERN for the benefit of the COMPASS Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).DFG [1102]; ICTP programme for Training and Research in Italian Laboratories (TRIL); German Bundesministerium fur Bildung und Forschung; Czech Republic MEYS Grants [ME492, LA242]; SAIL (CSR), Govt. of India; CERN-RFBR Grants [08-02-91009, 12-02-91500]; Portuguese FCT - Fundacao para a Ciencia e Tecnologia [CERN/FP/109323/2009, CERN/FP/116376/2010, CERN/FP/123600/2011]; MEXT; JSPS [18002006, 20540299, 18540281]; Daiko Foundation; Yamada Foundation; DFG cluster of excellence 'Origin and Structure of the Universe'; EU FP7 (HadronPhysics3) [283286]; Israel Science Foundation; Polish NCN Grant [DEC-2011/01/M/ST2/02350

Domatic Number of a Graph and its Variants (Extended Abstract)

This chapter presents some numerical invariants of graphs that are related to the concept of domination—namely, the domatic number and its variants.. The word domatic was coined from the words dominating and chromatic in the same way as the word smog was composed from the words smoke and fog. This concept is a certain analogy of the chromatic number, but instead of independent sets, dominating sets are used in its definition. A subset D of the vertex set V(G) of an undirected graphs G is called dominating if for each x V(G) − D there exists a vertex yD adjacent to x. A domatic partition of G is a partition of V(G), all of whose classes are dominating sets in G. The maximum number of classes of a domatic partition of G is called the “domatic number” of G and denoted by d(G). R. Laskar and S. T. Hedetniemi have introduced the connected domatic number d, (G) of a graph G. It is the maximum number of classes of a partition of V(G) into dominating sets that induce connected subgraphs of G.DFG [1102]; German Bundesministerium fur Bildung und Forschung; Czech Republic MEYS [ME492, LA242]; SAIL (CSR), Govt. of India; CERN-RFBR [08-02-91009, 12-02-91500]; Portuguese FCT - Fundacao para a Ciencia e Tecnologia [CERN/FP/109323/2009, CERN/FP/116376/2010, CERN/FP/123600/2011]; MEXT; JSPS [18002006, 20540299, 18540281]; Daiko Foundation; Yamada Foundation; DFG; EU [283286]; Israel Science Foundation; Polish NCN [DEC-2011/01/M/ST2/02350