5 research outputs found
Automated Neuropsychological Test Battery (CANTAB) in mild cognitive impairment and in Alzheimer's disease
A szkizofrĂ©n betegek kognitĂv deficitjĂ©nek jelentĹ‘sĂ©ge a klinikumban = The clinical importance of the cognitive deficits in schizophrenic patients.
A kutatási programunk cĂ©lkitűzĂ©se a szkizofrĂ©n betegek elsĹ‘, illetve Ăşjabb akut epizĂłdjaiban törtĂ©nĹ‘ komplex pszichofiziolĂłgiai, neurokognitĂv Ă©s klinikai vizsgálata a kognitĂv deficitek pontos meghatározására. A kutatási programunk során a cĂ©lkitűzĂ©snek megfelelĹ‘en vizsgáltuk a kognitĂv deficiteket negatĂv tĂĽnetes szkizofrĂ©n, továbbá prepszichotikus betegekben. A negatĂv tĂĽnetes betegek egy csoportjában a kognitĂv deficitet elektrofiziolĂłgiai mĂłdszerrel (auditoros kiváltott válasz) Ă©s pozitron emissziĂłs tomográfia (PET) párhuzamos alkalmazásával is vizsgáltuk a funkcionális eltĂ©rĂ©sek vizsgálatára. A klinikai alkalmazás Ă©s differenciál diagnĂłzis számára fontos, hogy a kognitĂv deficitek eltĂ©rĂ©seit kĂĽlönbözĹ‘ egyĂ©b betegcsoportokban: alkohol-dependens, depressziĂłs Ă©s Alzheimer demenciában szenvedĹ‘ betegekben is megvizsgáltuk Ă©s jellemzĹ‘ kognitĂv mintázatokat találtunk. A kutatási program vĂ©grehajtása egy Ă©vet csĂşszott, ennek oka volt, hogy csak 2004-ben sikerĂĽlt a CANTAB vizsgálati mĂłdszer legĂşjabb verziĂłjának adaptálása Ă©s a gyártĂł cĂ©ggel folytatott egyeztetetett installálási folyamat, mely után a kognitĂv számĂtĂłgĂ©pes battĂ©ria folyamatosan rendelkezĂ©sĂĽnkre áll. A meghosszabbĂtott periĂłdusnak megfelelĹ‘en a feladattervek is mĂłdosultak Ă©s a 2004. Ă©v során a mĂłdosĂtott terveknek megfelelĹ‘en haladt a kutatási program megvalĂłsĂtása. Az eredmĂ©nyeikrĹ‘l nemzetközi Ă©s hazai konferenciákon, illetve nemzetközi Ă©s magyar (peer-reviewed) publikáciĂł formájában számoltunk be. | The research project was aimed to determine the cognitive deficits in the first and consecutive acute episodes of schizophrenic patients with the help of a complex psychophysiological, neurocognitive and clinical research battery. According to the project aims the cognitive deficits were studied in schizophrenic patients with predominant negative symptoms and also in prepsychotic patients. A subgroup of schizophrenic patients with negative symptoms the cognitive deficits were also studied by eletrophysiological method (auditory evoked potential) with the parallel use of positron emitting tomography (PET). Specific cognitive deficit patterns were also described in a group of patients suffering from depression, Alzheimer dementia and substance abuse. These specific cognitive patterns are important for the clinical use and differential diagnosis. The realization of the research project was delayed by one year due to the later-than-expected adaptation and installation of the new version of CANTAB system by the system provider, nevertheless from 2004 the new version of the computerized cognitive battery has been available at our Department. Accordingly, the initial term of contract was been extended by one year in 2004 and the tasks were rescheduled and carried out according to the new research plan. Our results were presented at international and national congresses and also reported in peer-reviewed national and international scientific journals