Nanomanufacturing for biological sensing applications

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2007."February 2007."Includes bibliographical references (leaves 219-226).Over the past 10-15 years, there have been tremendous research efforts in the synthesis of nanomaterials with unique electronic properties. Much less work, however, has focused on the incorporation of the nanomaterials into electronic devices. In order for nanomaterials to have a technological impact in electronic devices, nanomanufacturing techniques must be established for the reliable and reproducible creation of devices with nanomaterials as the active component. In this thesis, the incorporation of 3-20 nm diameter ligand coated gold nanoparticles into an electronic device is studied. Ligand coated nanoparticles provide great control over their solubility and electronic properties through the choice of protecting ligand molecule. The use of an isolated nanoparticle in electronic devices presents two major difficulties which are studied in detail in this work. In order to use the electrical properties of a single particle or a few particles, insulating gaps in metallic electrodes must be fabricated with dimensions of 5-50 nm. Several methods including direct patterning with electron beam lithography, physical methods of gap formation, and electrical methods of gap formation are described, studied and evaluated for use in nanomanufacturing.(cont.) A second major challenge is the specific assembly of nanoparticles into the nanogaps. The use of chemically directed assembly to pattern particles on templates generated by Dip Pen Nanolithography is described using several different surface chemistries. An electrical based method, dielectrophoresis, is found to be better suited for assembly of particles into the gaps and the forces which affect assembly are studied in detail. Electrical characterizations of networks of 10-200 nanoparticles are studied as a function of protecting ligand molecule. Preliminary results on the use of nanomanufactured devices consisting of gold nanoparticles-oglionucleotide conjugates bridging a nano-gap for DNA sensing are presented.by Robert J. Barsotti, Jr.Ph.D

Gravitational Waves and Gamma-Rays from a Binary Neutron Star Merger: GW170817 and GRB 170817A

On 2017 August 17, the gravitational-wave event GW170817 was observed by the Advanced LIGO and Virgo detectors, and the gamma-ray burst (GRB) GRB 170817A was observed independently by the Fermi Gamma-ray Burst Monitor, and the Anti-Coincidence Shield for the Spectrometer for the International Gamma-Ray Astrophysics Laboratory. The probability of the near-simultaneous temporal and spatial observation of GRB 170817A and GW170817 occurring by chance is 5.0 × 10 -8 . We therefore confirm binary neutron star mergers as a progenitor of short GRBs. The association of GW170817 and GRB 170817A provides new insight into fundamental physics and the origin of short GRBs. We use the observed time delay of (+1.74±0.05)between GRB 170817A and GW170817 to: (i) constrain the difference between the speed of gravity and the speed of light to be between -3 × 10 -15 and +7 × 10 -16 times the speed of light, (ii) place new bounds on the violation of Lorentz invariance, (iii) present a new test of the equivalence principle by constraining the Shapiro delay between gravitational and electromagnetic radiation. We also use the time delay to constrain the size and bulk Lorentz factor of the region emitting the gamma-rays. GRB 170817A is the closest short GRB with a known distance, but is between 2 and 6 orders of magnitude less energetic than other bursts with measured redshift. A new generation of gamma-ray detectors, and subthreshold searches in existing detectors, will be essential to detect similar short bursts at greater distances. Finally, we predict a joint detection rate for the Fermi Gamma-ray Burst Monitor and the Advanced LIGO and Virgo detectors of 0.1-1.4 per year during the 2018-2019 observing run and 0.3-1.7 per year at design sensitivity

Search for High-energy Neutrinos from Binary Neutron Star Merger GW170817 with ANTARES, IceCube, and the Pierre Auger Observatory

The Advanced LIGO and Advanced Virgo observatories recently discovered gravitational waves from a binary neutron star inspiral. A short gamma-ray burst (GRB) that followed the merger of this binary was also recorded by the Fermi Gamma-ray Burst Monitor (Fermi-GBM), and the Anti-Coincidence Shield for the Spectrometer for the International Gamma-Ray Astrophysics Laboratory (INTEGRAL), indicating particle acceleration by the source. The precise location of the event was determined by optical detections of emission following the merger. We searched for high-energy neutrinos from the merger in the GeV-EeV energy range using the Antares, IceCube, and Pierre Auger Observatories. No neutrinos directionally coincident with the source were detected within ± 500 s around the merger time. Additionally, no MeV neutrino burst signal was detected coincident with the merger. We further carried out an extended search in the direction of the source for high-energy neutrinos within the 14 day period following the merger, but found no evidence of emission. We used these results to probe dissipation mechanisms in relativistic outflows driven by the binary neutron star merger. The non-detection is consistent with model predictions of short GRBs observed at a large off-axis angle

Gravitational Waves From Known Pulsars: Results From The Initial Detector Era

We present the results of searches for gravitational waves from a large selection of pulsars using data from the most recent science runs (S6, VSR2 and VSR4) of the initial generation of interferometric gravitational wave detectors LIGO (Laser Interferometric Gravitational-wave Observatory) and Virgo. We do not see evidence for gravitational wave emission from any of the targeted sources but produce upper limits on the emission amplitude. We highlight the results from seven young pulsars with large spin-down luminosities. We reach within a factor of five of the canonical spin-down limit for all seven of these, whilst for the Crab and Vela pulsars we further surpass their spin-down limits. We present new or updated limits for 172 other pulsars (including both young and millisecond pulsars). Now that the detectors are undergoing major upgrades, and, for completeness, we bring together all of the most up-to-date results from all pulsars searched for during the operations of the first-generation LIGO, Virgo and GEO600 detectors. This gives a total of 195 pulsars including the most recent results described in this paper.United States National Science FoundationScience and Technology Facilities Council of the United KingdomMax-Planck-SocietyState of Niedersachsen/GermanyAustralian Research CouncilInternational Science Linkages program of the Commonwealth of AustraliaCouncil of Scientific and Industrial Research of IndiaIstituto Nazionale di Fisica Nucleare of ItalySpanish Ministerio de Economia y CompetitividadConselleria d'Economia Hisenda i Innovacio of the Govern de les Illes BalearsNetherlands Organisation for Scientific ResearchPolish Ministry of Science and Higher EducationFOCUS Programme of Foundation for Polish ScienceRoyal SocietyScottish Funding CouncilScottish Universities Physics AllianceNational Aeronautics and Space AdministrationOTKA of HungaryLyon Institute of Origins (LIO)National Research Foundation of KoreaIndustry CanadaProvince of Ontario through the Ministry of Economic Development and InnovationNational Science and Engineering Research Council CanadaCarnegie TrustLeverhulme TrustDavid and Lucile Packard FoundationResearch CorporationAlfred P. Sloan FoundationAstronom

All-sky search for continuous gravitational waves from isolated neutron stars using Advanced LIGO O2 data

© 2019 American Physical Society. We present results of an all-sky search for continuous gravitational waves (CWs), which can be produced by fast spinning neutron stars with an asymmetry around their rotation axis, using data from the second observing run of the Advanced LIGO detectors. Three different semicoherent methods are used to search in a gravitational-wave frequency band from 20 to 1922 Hz and a first frequency derivative from -1×10-8 to 2×10-9 Hz/s. None of these searches has found clear evidence for a CW signal, so upper limits on the gravitational-wave strain amplitude are calculated, which for this broad range in parameter space are the most sensitive ever achieved

First low-frequency Einstein@Home all-sky search for continuous gravitational waves in Advanced LIGO data

We report results of a deep all-sky search for periodic gravitational waves from isolated neutron stars in data from the first Advanced LIGO observing run. This search investigates the low frequency range of Advanced LIGO data, between 20 and 100 Hz, much of which was not explored in initial LIGO. The search was made possible by the computing power provided by the volunteers of the Einstein@Home project. We find no significant signal candidate and set the most stringent upper limits to date on the amplitude of gravitational wave signals from the target population, corresponding to a sensitivity depth of 48.7 [1/root Hz]. At the frequency of best strain sensitivity, near 100 Hz, we set 90% confidence upper limits of 1.8 x 10(-25). At the low end of our frequency range, 20 Hz, we achieve upper limits of 3.9 x 10(-24). At 55 Hz we can exclude sources with ellipticities greater than 10(-5) within 100 pc of Earth with fiducial value of the principal moment of inertia of 10(38) kg m(2)

Search for intermediate mass black hole binaries in the first observing run of Advanced LIGO

During their first observational run, the two Advanced LIGO detectors attained an unprecedented sensitivity, resulting in the first direct detections of gravitational-wave signals produced by stellar-mass binary black hole systems. This paper reports on an all-sky search for gravitational waves (GWs) from merging intermediate mass black hole binaries (IMBHBs). The combined results from two independent search techniques were used in this study: the first employs a matched-filter algorithm that uses a bank of filters covering the GW signal parameter space, while the second is a generic search for GW transients (bursts). No GWs from IMBHBs were detected; therefore, we constrain the rate of several classes of IMBHB mergers. The most stringent limit is obtained for black holes of individual mass 100 M ⊙, with spins aligned with the binary orbital angular momentum. For such systems, the merger rate is constrained to be less than 0.93 Gpc−3yr−1 in comoving units at the 90% confidence level, an improvement of nearly 2 orders of magnitude over previous upper limits

Chemically directed assembly of monolayer protected gold nanoparticles on lithographically generated patterns

Diamine molecules were used to chemically direct the assembly of carboxylic acid terminated monolayer protected gold nanoparticles onto Au surfaces patterned with mercapto-hexadecanoic-acid by microcontact printing or dip pen nanolithography

Investigation on ultrasonic welding attributes of novel carbon/elium® composites

Joining large and complex polymer-matrix composite structures is becoming increasingly important in industries such as automobiles, aerospace, sports, wind turbines, and others. Ultrasonic welding is an ultra-fast joining process and also provides excellent joint quality as a cost-effective alternative to other joining processes. This research aims at investigating the welding characteristics of novel methyl methacrylate Elium®, a liquid thermoplastic resin. Elium® is the first of its kind of thermoplastic resin, which is curable at room temperature and is suitable for mass production processes. The welding characteristics of Elium® composites were investigated by optimizing the welding parameters with specially designed integrated energy directors (ED) and manufactured using the Resin transfer molding process. The results showed a 23% higher lap shear strength for ultrasonically welded composite joints when compared to the adhesively bonded joints. The optimized welding time for the ultrasonic welded joint was found to be 1.5 s whereas it was 10 min for the adhesively bonded joint. Fractographic analysis showed the significant plastic deformation and shear cusps formation on the fractured surface, which are typical characteristics for strong interfacial bonding.Nanyang Technological UniversityPublished versionThis research was funded by Nanyang Technological University, Singapore and ARKEMA, Franceunder RCA-18/46 and RIE2020 Advanced Manufacturing and Engineering (AME) domain—Industry AlignmentFund—Pre-positioning polymer matrix composites program

Fatigue response of ultrasonically welded carbon/Elium® thermoplastic composites

Current research aims at investigating the fatigue strength of ultrasonically welded composite joints with novel liquid acrylic thermoplastic Elium®. Fatigue response of the welded joints with integrated Energy Director (ED) and flat Elium® film was investigated and the baseline comparison was carried out with control adhesives. The results showed 10–12% higher fatigue life at 105 and 106 fatigue cycle as compared to the adhesively bonded joints. Fractographic investigation of fractured welded joints showed features such as fibre impingement and shear cusps formation which contributed to strong interfacial adhesion.Nanyang Technological UniversityThis research was funded by Nanyang Technological University, Singapore and ARKEMA, France under RCA-18/46 and RIE2020 Advanced Manufacturing and Engineering (AME) domain–Industry Alignment Fund–Pre-positioning polymer matrix composites program