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Tamoxifen and related compounds decrease membrane fluidity in liposomes Mechanism for the antioxidant action of tamoxifen and relevance to its anticancer and cardioprotective actions?
AbstractTamoxifen and related compounds decrease membrane fluidity in ox-brain phospholipid liposomes: their order of effectiveness is, 4-hydroxytamoxifen > 17β-oestradiol > tamoxifen >cis-tamoxifen >N-desmethyltamoxifen > cholesterol. A good positive correlation was demonstrated between the decrease in membrane fluidity by these compounds and their antioxidant ability as inhibitors of liposomal and microsomal lipid peroxidation (correlation coefficient, r = 0.99, P < 0.001, in both cases). The ability of tamoxifen to decrease membrane fluidity is suggested to be the mechanism of its antioxidant action and is discussed in relation to its anticancer and cardioprotective actions
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Adapting the International System of Units to the twenty-first century
We review the proposal of the International Committee for Weights and Measures
(Comité International des Poids et Mesures, CIPM), currently being considered by
the General Conference on Weights and Measures (Conférences Générales des Poids et
Mesures, CGPM), to revise the International System of Units (Le Système International
d’Unitès, SI). The proposal includes new definitions for four of the seven base units of
the SI, and a new form of words to present the definitions of all the units. The objective
of the proposed changes is to adopt definitions referenced to constants of nature, taken
in the widest sense, so that the definitions may be based on what are believed to be
true invariants. In particular, whereas in the current SI the kilogram, ampere, kelvin and
mole are linked to exact numerical values of the mass of the international prototype of the
kilogram, the magnetic constant (permeability of vacuum), the triple-point temperature
of water and the molar mass of carbon-12, respectively, in the new SI these units are linked
to exact numerical values of the Planck constant, the elementary charge, the Boltzmann
constant and the Avogadro constant, respectively. The new wording used expresses the
definitions in a simple and unambiguous manner without the need for the distinction
between base and derived units. The importance of relations among the fundamental
constants to the definitions, and the importance of establishing a mise en pratique for
the realization of each definition, are also discussed
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