3,134 research outputs found

    Positive definiteness of the blended force-based quasicontinuum method

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    The development of consistent and stable quasicontinuum models for multidimensional crystalline solids remains a challenge. For example, proving the stability of the force-based quasicontinuum (QCF) model [M. Dobson and M. Luskin, M2AN Math. Model. Numer. Anal., 42 (2008), pp. 113--139] remains an open problem. In one and two dimensions, we show that by blending atomistic and Cauchy--Born continuum forces (instead of a sharp transition as in the QCF method) one obtains positive-definite blended force-based quasicontinuum (B-QCF) models. We establish sharp conditions on the required blending width

    Positive definiteness of the blended force-based quasicontinuum method

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    The development of consistent and stable quasicontinuum models for multidimensional crystalline solids remains a challenge. For example, proving the stability of the force-based quasicontinuum (QCF) model [M. Dobson and M. Luskin, M2AN Math. Model. Numer. Anal., 42 (2008), pp. 113--139] remains an open problem. In one and two dimensions, we show that by blending atomistic and Cauchy--Born continuum forces (instead of a sharp transition as in the QCF method) one obtains positive-definite blended force-based quasicontinuum (B-QCF) models. We establish sharp conditions on the required blending width

    Creative dance as experiential learning in state primary education: The Potential Benefits for Children

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    © The Author(s) 2020. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).Background: Taking the UK National Curriculum as an example, creative dance is part of physical education classified as a foundation subject rather than an important core subject. Purpose: The article’s primary aim is to examine a range of literature exploring any potential benefits of the role of creative dance for children aged 3-11 years in mainstream state education to evaluate whether creative dance can be categorised as experiential learning. Methodology/Approach: The search included key words in several data bases. The analysis arrived at some potential benefits which can be framed within experiential learning. Findings /Conclusion: This section identifies some benefits of creative dance in socio-emotional, arts-based, transferable, embodied, physical, and cognitive learning. It concludes that conceptualising creative dance as experiential learning could support the consideration of it filling a more central role in the curriculum. Implications: This article breaks new ground in experiential learning re-contextualising the role of creative dance in children’s learning through reviewing some related literature. There is a claim to be made for creative dance to play a more central role in the curriculum when the benefits and its process are framed as experiential learning.Peer reviewe

    E-survey of current international physiotherapy practice for children with ataxia following surgical resection of posterior fossa tumour.

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    ObjectiveTo determine current international practice regarding physiotherapy input for children with ataxia following surgery for posterior fossa tumour. Design: An e-survey covering the following domains: participant demographics, treatment/ intervention, virtual training, intensity/timing of treatment, and aims and outcomes of physiotherapy management.ParticipantsPhysiotherapists involved in the management of children with ataxia following surgical resection of posterior fossa tumour. Participants were contacted via 6 key groups; Paediatric Oncology Physiotherapy Network (POPs), Association of Paediatric Chartered Physiotherapists (APCP), European Paediatric Neurology Society (EPNS), International Society of Paediatric Oncology (SIOP)-Europe Brain Tumour Group, Posterior Fossa Society (PFS), and Pediatric Oncology Special Interest Group (SIG) (American Physical Therapy Association).ResultsA total of 96 physiotherapists participated: UK (n =53), rest of Europe (n = 23), USA/ Canada (n = 10), and Australia/NZ (n = 10). The most common physiotherapy interventions used were balance exercises, gait re-education and proximal control activities. The most frequently used adjuncts to treatment were mobility aids and orthotics. Challenges reported regarding physiotherapy treatment were: reduced availability of physiotherapy input following discharge from the acute setting, lack of evidence, impact of adjuvant oncology treatment, and psychosocial impact.ConclusionThis e-survey provides an initial scoping review of international physiotherapy practice in this area. It establishes a foundation for future research on improving rehabilitation of ataxia in this population

    Tamoxifen and related compounds decrease membrane fluidity in liposomes Mechanism for the antioxidant action of tamoxifen and relevance to its anticancer and cardioprotective actions?

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    AbstractTamoxifen and related compounds decrease membrane fluidity in ox-brain phospholipid liposomes: their order of effectiveness is, 4-hydroxytamoxifen > 17β-oestradiol > tamoxifen >cis-tamoxifen >N-desmethyltamoxifen > cholesterol. A good positive correlation was demonstrated between the decrease in membrane fluidity by these compounds and their antioxidant ability as inhibitors of liposomal and microsomal lipid peroxidation (correlation coefficient, r = 0.99, P < 0.001, in both cases). The ability of tamoxifen to decrease membrane fluidity is suggested to be the mechanism of its antioxidant action and is discussed in relation to its anticancer and cardioprotective actions

    Psychiatric co morbidity in epilepsy, psychiatric and psychosocial morbidity before and after surgical treatment.

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    Introduction Epilepsy is a common disease with an incidence of 20-70 per 100 000 annually and prevalence of 0.5-1 % of the population. Data to date assessing psychopathology in refractory epilepsy patients is conflicting. In a subgroup of medically refractory epilepsy patients, surgical intervention is considered. Studies of outcome after neurosurgical resection of epileptogenic tissue or temporal lobectomy focus on frequency of seizures as their primary outcome measure. Neurosurgical intervention for epilepsy is associated with significant undesired psychiatric consequences including psychosis, major depression, obsessive compulsive disorder and suicide. Methods This study is prospective cohort study which examined a group of patients with medically refractory epilepsy, and also examined a cohort who proceeded to surgery before and after surgery. This study used the Hospital Anxiety and Depression Scale (HADS) and the Structured Clinical Interview for DSM IV (SCID I), to examine for an axis-1 psychiatric diagnosis. In addition, the study assessed the presence of personality disorder using the SCID-II. The Quality of life in Epilepsy (QOLIE-89) assessed social outcome. All patients admitted to the Epilepsy Monitoring Unit or who attended the Neurology OPD in Beaumont Hospital with treatment resistant epilepsy are considered a candidate for inclusion. All participants were assessed using the same instruments as those unwilling to participate. Those that proceeded to surgery were reassessed three to six-months after surgery using the same structured interview and standardised self rating questionnaires. Conclusions The findings of this study demonstrated the high prevalence of psychiatric comorbidity (49%) in patients with medically refractory epilepsy. In addition, the presence of a psychiatric disorder and the severity of the symptoms of psychiatric illness were correlated strongly with quality of life. Overall, this study has demonstrated that undergoing surgery for medically refractory epilepsy had an overall positive Impact on mental health with a significant reduction in the severity and prevalence of psychiatric symptoms and an improved quality of life

    Tamoxifen and related compounds decrease membrane fluidity in liposomes Mechanism for the antioxidant action of tamoxifen and relevance to its anticancer and cardioprotective actions?

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    AbstractTamoxifen and related compounds decrease membrane fluidity in ox-brain phospholipid liposomes: their order of effectiveness is, 4-hydroxytamoxifen > 17β-oestradiol > tamoxifen >cis-tamoxifen >N-desmethyltamoxifen > cholesterol. A good positive correlation was demonstrated between the decrease in membrane fluidity by these compounds and their antioxidant ability as inhibitors of liposomal and microsomal lipid peroxidation (correlation coefficient, r = 0.99, P < 0.001, in both cases). The ability of tamoxifen to decrease membrane fluidity is suggested to be the mechanism of its antioxidant action and is discussed in relation to its anticancer and cardioprotective actions

    Gerard Manley Hopkins: Sacramentalist and Incarnationist

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    It is the purpose of this dissertation to reveal Gerard Manley Hopkins as an incarnationist and sacramentalist, and to show how these doctrines manifested throughout his poetry affected the entire scope of his verse and completely colored his attitude toward life-- toward his own existence and that of his fellow man, and especially toward natural phenomena

    'On Licence: Understanding punishment, recidivism and desistance in penal policy, 1853-1945'

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    During the nineteenth and early twentieth centuries, British legislators reacted to the perceived growth in a hard core of violent repeat offenders and struggled to fi nd solutions to the problem of recidivism. The concept of dangerousness, and the potential threat posed by those people who appeared to be less affected by civilising processes that appeared to be effective in making Britain a safer place to live, have since been a recurring topic of study for researchers of nineteenth-century society. 1 Others, such as Leon Radzinowicz and Roger Hood, have focused more on legislation such as the Penal Servitude Acts (1853–64), Habitual Offender Acts (1869–91) and the Preventive Detention Act (1908), which were designed to incapacitate offenders through the imposition of long prison sentences and extended police supervision. 2 In an attempt to make the system to work effectively, a vast bureaucracy was created which was responsible for the identifi cation and tracking of many thousands of former prisoners and convicts. This served to create a huge range and number of archived written documentary records – many of which can now be utilised by historians to examine the impact of particular forms of legislation on offenders and the length of their criminal careers. In this chapter we present some case studies in order to outline both the possibilities, and also some of the possible pitfalls, of using these bureaucratic records in modern research. We contribute to the debates initiated by Radzinowicz and Hood by examining the impact of penal practices and policies on repeat offenders in order to understand the relative effects of punishment and surveillance, and also other signifi cant events in individual offenders’ lives, on their offending over the whole course of their lives
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