Experimental intraspinal Trypanosoma equiperdum infection in a horse

To establish the ability of Trypanosoma equiperdum to cross the blood-brain-barrier in the horse, a susceptible stallion was infected via the cerebrospinal fluid of the subarachnoid space by lumbosacral puncture. Cerebrospinal fluid with low detectable levels of trypanosomes removed from a dourine-infected mare by lumbosacral puncture was used for infecting the animal. The parasite was detected in blood smears of the recipient 13 days after infection and the subsequent parasitaemia and clinical course of the disease followed that of naturally infected horses.The articles have been scanned in colour with a HP scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to final presentyation PDF-Format

Observations on the transmission, immunology, clinical signs and chemotherapy of dourine (Trypanosoma equiperdum infection) in horses, with special reference to cerebro-spinal fluid

This paper is a record of observations on the transmission and clinical signs of dourine in naturally infected cases of known duration, and of temporal and quantitative aspects of the immune response in blood and cerebro-spina l fluid. Included in the record are observations on the presence of Trypanosoma equiperdutll parasites in these body fluids and methods for their detection. There is evidence that the occurrence of nervous symptoms and lesions in infected horses is associated with the presence of Trypanosoma equiperdunt parasites in cerebro-spinal fluid. The suitability of cerebro-spinal fluid as an environment for the parasite and its relationship with nervous manifestations of the disease are discussed. Observations support the previously reported lesions of peripheral polyneurit is and suggest a possible con•eJation between the consistent position of the nervous lesions and the drainage of cerebro-spinal fluid containing the parasite. Chemotherapy with an experimental drug MSbE was used with varying results in 4 horses at different stages of infection.The articles have been scanned in colour with a HP scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to final presentyation PDF-Format

Lymph node pathology in Trypanosoma brucei-infected sheep

The temporal sequence of morphological changes occurring in the prefemoral lymph nodes of sheep experimentally infected with Trypanosoma brucei was studied at weekly intervals during the course of infection. Histopathological changes started with lymphoid stimulation which was soon overtaken and masked by intense proliferation of reticulo-endothelial cells. Reticulo-endothelial proliferation resulted in macrophage accumulation, some vascular damage and lymph stasis, varying from insidious to extensive. Reticulo-endothelial activity subsequently decreased and there was an upsurge of proliferative activity in lymphoid tissue. Lymphoid stimulation resulted in increased numbers of primary follicles with active germinal centres and produced cells primarily lymphoblast/plasmablast in type. The response appeared to involve blast cells of the germinal centres rather than thymus-dependent paracortical areas. Both reticulo-endothelial and lymphoid components exhibited marked cellular necrosis which increased throughout the course of infection. Intense lymphopoiesis was not correlated with lymphocytosis but was associated with lymphopaenia.This article has been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-Format

Amicarbalide : a therapeutic agent for anaplasmosis

When administered subcutaneously in 2 equal daily doses at a total dosage rate of 20 mg/kg, amicarbalide was found to be an effective agent for controlling acute infections of Anaplasma marginate and A. centrale in intact and splenectomized cattle. Attempts to sterilize patent and latent Anaplasma infections, however, were unsuccessful. At total dosage rates of 40 mg/kg and higher, amicarbalide exhibited potent hepato- and nephrotoxic tendencies.The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

The influence of breed and dietary molybdenum on the concentration of copper in tissues of sheep

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