International Journal of Pediatric Otorhinolaryngology

Trabalho completo: acesso restrito, p. 1780–1785Objective Obstructive sleep apnea syndrome (OSAS) in cystic fibrosis (CF) patients may be associated with the presence of upper airway obstruction caused by chronic infection and nasal polyposis that may also contribute to OSAS severity. Our objective was to identify the profile of findings in CF and OSAS patients by performing upper airway examinations. Methodology Observational, cross-sectional study involving 63 children and adolescents between the ages of 2 and 14 with CF. All patients answered a questionnaire and underwent a standard otolaryngology examination, including an endoscopic nasal and nocturnal polysomnography. OSAS diagnosis was confirmed if the obstructive apnea index was ≥1. Results OSAS was identified in 35 (55.6%) patients. The upper airway findings were evaluated using multiple correspondence factorial analysis. The OSAS group presented with overjet >2 mm, enlarged pharyngeal pillars, palatine tonsils and pharyngeal tonsils hypertrophy, ogival hard palates and characteristics of chronic rhinosinusitis. Conclusion Bone and soft tissue structural alterations of the upper airway and chronic rhinosinusitis were associated with the OSAS group patients

Microbiology of the middle meatus compared to sputum in young patients with cystic fibrosis from Bahia - Brazil.

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2014-10-01T19:18:50Z No. of bitstreams: 1 Tunes A Microbiology....pdf: 438662 bytes, checksum: 0083c83a175d1396c9eb13c405d281e1 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2014-10-01T19:19:05Z (GMT) No. of bitstreams: 1 Tunes A Microbiology....pdf: 438662 bytes, checksum: 0083c83a175d1396c9eb13c405d281e1 (MD5)Made available in DSpace on 2014-10-01T19:36:13Z (GMT). No. of bitstreams: 1 Tunes A Microbiology....pdf: 438662 bytes, checksum: 0083c83a175d1396c9eb13c405d281e1 (MD5) Previous issue date: 2013Postgraduate Course in Medicine and Human Health of Bahian School of Medicine and Public Health. Salvador, BA, Brasil / Federal University of Bahia. Microbiological Laboratory. School of Pharmacy. Salvador, BA, BrasilFederal University of Bahia. Microbiological Laboratory. School of Pharmacy. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilPostgraduate Course in Medicine and Human Health of Bahian School of Medicine and Public Health. Salvador, BA, Brasil / Octávio Mangabeira Hospital. BrazilcPediatric Pulmonary Clinic of Bahia Reference Center for Cystic Fibrosis. Salvador, BA, BrasilOctávio Mangabeira Hospital. Pediatric Pulmonary Clinic of Bahia Reference Center for Cystic Fibrosis. Salvador, BA, BrasilOctávio Mangabeira Hospital. Pediatric Pulmonary Clinic of Bahia Reference Center for Cystic Fibrosis. Salvador, BA, BrasilFederal University of Bahia. Microbiological Laboratory. School of Pharmacy. Salvador, BA, BrasilFederal University of Bahia. Microbiological Laboratory. School of Pharmacy. Salvador, BA, BrasilOctávio Mangabeira Hospital. Microbiological Laboratory. Salvador, BA, BrasilPostgraduate Course in Medicine and Human Health of Bahian School of Medicine and Public Health. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilLower airway infection is a major cause of morbidity and mortality in patients with cystic fibrosis. It is currently unknown if the infection of the upper airway can cause exacerbation of lower respiratory tract infection. This study aimed to determine the microbiological profile of the anterior paranasal sinuses outflow tract (middle meatus) of cystic fibrosis outpatients. The microbiological profile was defined using endoscopically directed middle meatal cultures. Paired middle meatal and sputum specimens were collected from 56 outpatients for aerobic cultures. A semi-quantitative leukocyte count of the middle meatal samples was performed. The median age of patients was nine years (3-20 years). Staphylococcus aureus (37%), Staphylococcus coagulase-negative (25%), Neisseriac (14%), Pseudomonas aeruginosa (11%), and Streptococcus pneumoniae (7%) were the most prevalent microorganisms in the middle meatal cultures. Using the middle meatal leukocyte count, 16 out of 54 patients (29.6%) presented sinus infection. The most frequently identified pathogens in patients with sinus infections were Staphylococcus aureus (10 patients), Pseudomonas aeruginosa (4 patients), and Streptococcus pneumoniae (3 patients). Agreement of paired middle meatal and sputum cultures was significantly higher among patients with infection in middle meatal (69%). The most common middle meatal pathogens were the typical cystic fibrosis spectrum. This suggests the potential for participating in post-nasal lower airway seedin