915 research outputs found
Vermicompost as a fertilizer for urban and peri-urban farms: Perceptions of farmers in Accra, Ghana
Vermicompost is considered a valuable organic fertilizer in many tropical regions, but has rarely been used in sub-Saharan Africa. A study in Accra, Ghana, assessed urban and peri-urban (UP) farmers’ fertilizer and pesticide use, knowledge of earthworms, fertilizer performance criteria, and attitudes toward vermicompost as a fertilizer. Twenty-six farmers involved in irrigated vegetable farming and three subsistence farmers were interviewed. Farmers were aware that earthworm activity was associated with soil fertility, and some associated insecticide applications to reduced earthworm populations. Farmers used the greenness of leaves, crop emergence, stand and yield as indicators of fertilizer performance. Farmers resisted making statements about vermicompost before testing it, and advised that its fertilizer value be tested during the dry season. Farmers involved in irrigated vegetable farming had insufficient space and time for on-farm vermicomposting, while subsistence farmers lacked a reliable access to water necessary for on-farm vermicomposting; but both types of farmers were interested in adopting vermicompost if it improved crop performance. Such lack of farm resources suggest that a commercial facility would be best suited to produce vermicompost from organic waste, which would then be sold to farmers
Descriptive Complexity of Deterministic Polylogarithmic Time and Space
We propose logical characterizations of problems solvable in deterministic
polylogarithmic time (PolylogTime) and polylogarithmic space (PolylogSpace). We
introduce a novel two-sorted logic that separates the elements of the input
domain from the bit positions needed to address these elements. We prove that
the inflationary and partial fixed point vartiants of this logic capture
PolylogTime and PolylogSpace, respectively. In the course of proving that our
logic indeed captures PolylogTime on finite ordered structures, we introduce a
variant of random-access Turing machines that can access the relations and
functions of a structure directly. We investigate whether an explicit predicate
for the ordering of the domain is needed in our PolylogTime logic. Finally, we
present the open problem of finding an exact characterization of
order-invariant queries in PolylogTime.Comment: Submitted to the Journal of Computer and System Science
Maximum tumor diameter is associated with event-free survival in PET-negative patients with stage I/IIA Hodgkin lymphoma.
Introduction: the high cure rates achieved in early-stage (ES) Hodgkin lymphoma (HL) are one of the great successes of hemato-oncology, but late treatment-related toxicity undermines long-term survival. Improving overall survival and quality of life further will require maintaining disease control while potentially de-escalating chemotherapy and/or omitting radiotherapy to reduce late toxicity. Accurate stratification of patients is required to facilitate individualized treatment approaches. Response assessment using 18F-fluorodeoxyglucose positron emission tomography (PET) is a powerful predictor of outcome in HL,1,2 and has been used in multiple studies, including the United Kingdom National Cancer Research Institute Randomised Phase III Trial to Determine the Role of FDG–PET Imaging in Clinical Stages IA/IIA Hodgkin’s Disease (UK NCRI RAPID) trial, to investigate whether patients achieving complete metabolic remission (CMR) can be treated with chemotherapy alone.3-5 These PET-adapted trials have demonstrated that omitting radiotherapy results in higher relapse rates, but without compromising overall survival.3-5
For the 75% of patients who achieved CMR in RAPID, neither baseline clinical risk stratification (favorable/unfavorable) nor PET (Deauville score 1/2) predicted disease relapse; additional biomarkers are needed.1 Tumor bulk has long been recognized as prognostic in HL,1,6 but there remains uncertainty about the significance and definition of bulk in the era of PET-adapted treatment.7 We performed a subsidiary analysis of RAPID to assess the prognostic value of baseline maximum tumor dimension (MTD) in patients achieving CMR.
Methods: ee have previously reported the RAPID trial design, primary results, and outcomes according to pretreatment risk stratification and PET score.1,3 Patients were aged 16 to 75 years with untreated ES-HL and without B-symptoms or mediastinal bulk (mass > 1/3 internal mediastinal diameter at T5/6).6 Metabolic response after 3 cycles of ABVD chemotherapy (doxorubicin, bleomycin, vinblastine, and dacarbazine) was centrally assessed using PET (N = 562). Patients with CMR (ie, Deauville score 1-2) were randomly assigned to receive involved field radiotherapy (IFRT; n = 208) or no further therapy (NFT; n = 211). PET-positive patients (score, 3-5; n = 143) received a fourth cycle of ABVD and IFRT.
Baseline disease assessment was performed by computed tomography, and bidimensional target lesion measurements were reported by local radiologists in millimeters. The association of baseline MTD with HL-related event-free survival (EFS: progression or HL-related death) and progression-free survival (PFS) (progression or any-cause death) was assessed using Kaplan-Meier and Cox regression analyses. Non-HL deaths were either related to primary treatment toxicity or occurred in HL remission.1
United Kingdom ethical approval for the RAPID trial was via the UK Multicentre Research ethics committee.
Results and discussion: baseline patient characteristics have been previously described.1 Median age was 34 years (range, 16-75 years); 184 (37.4%) of 492 patients had unfavorable risk by European Organisation for Research and Treatment of Cancer criteria, and 155 (32.3%) of 480 by German Hodgkin Study Groupcriteria. Median MTD for patients achieving CMR was 3.0 cm (interquartile range, 2.0-4.0 cm) and 3.0 cm (interquartile range, 1.8-4.5 cm) in the NFT and IFRT groups, respectively, whereas PET-positive patients had a median MTD of 3.9 cm (interquartile range, 2.8-5.1 cm). After a median follow-up of 61.6 m, 44 HL progression events occurred: 21 NFT, 9 IFRT and 14 PET-positive. No patient received salvage treatment without documented progression. Only 5 HL-related deaths occurred (1 IFRT, 4 PET-positive), and 12 non-HL deaths (4 NFT, 6 IFRT, 2 PET-positive).1
For patients with CMR (N = 419), there was a strong association between MTD and EFS (hazard ratio [HR], 1.19; 95% confidence interval [CI], 1.02-1.39; P = .02), adjusting for treatment group, with an approximate 19% increase in HL risk per centimeter increase in MTD. The association was similar in both treatment groups (NFT HR, 1.20 [95% CI, 0.99-1.44; P = .06]; IFRT HR, 1.19 [95% CI, 0.92-1.55; P = .19]). The observed effect sizes did not markedly change after adjusting for baseline clinical risk factors, and similar results were observed for PFS (supplemental Table 1). In contrast, for PET-positive patients, there was no association between MTD and EFS (HR, 0.88; 95% CI, 0.70-1.11; P = .29) or PFS (HR, 0.87; 95% CI, 0.70-1.08; P = .21).
In an exploratory analysis within the NFT group, MTD was dichotomized using increasing 1-cm intervals to investigate the relationship between MTD thresholds and EFS. The largest effect size was observed with an MTD threshold of ≥5 cm (Table 1). Similar results were observed for PFS; this threshold also performed best in time-dependent receiver operating characteristic curve analyses. It was not possible to assess MTD thresholds in the IFRT group with only 9 events. Among all randomized patients, 79 (18.9%) had MTD of ≥5 cm, the majority with mediastinal (n = 43), supraclavicular (n = 17), or cervical (n = 16) locations. Five-year EFS for patients with MTD of ≥5 cm randomly assigned to NFT and IFRT was 79.3% (n = 39; 95% CI, 66.6%-92.0%) and 94.9% (n = 40; 95% CI, 88.0%-100%), respectively (P = .03; Figure 1)
Interpretations of Presburger Arithmetic in Itself
Presburger arithmetic PrA is the true theory of natural numbers with
addition. We study interpretations of PrA in itself. We prove that all
one-dimensional self-interpretations are definably isomorphic to the identity
self-interpretation. In order to prove the results we show that all linear
orders that are interpretable in (N,+) are scattered orders with the finite
Hausdorff rank and that the ranks are bounded in terms of the dimension of the
respective interpretations. From our result about self-interpretations of PrA
it follows that PrA isn't one-dimensionally interpretable in any of its finite
subtheories. We note that the latter was conjectured by A. Visser.Comment: Published in proceedings of LFCS 201
Randomisation and Derandomisation in Descriptive Complexity Theory
We study probabilistic complexity classes and questions of derandomisation
from a logical point of view. For each logic L we introduce a new logic BPL,
bounded error probabilistic L, which is defined from L in a similar way as the
complexity class BPP, bounded error probabilistic polynomial time, is defined
from PTIME. Our main focus lies on questions of derandomisation, and we prove
that there is a query which is definable in BPFO, the probabilistic version of
first-order logic, but not in Cinf, finite variable infinitary logic with
counting. This implies that many of the standard logics of finite model theory,
like transitive closure logic and fixed-point logic, both with and without
counting, cannot be derandomised. Similarly, we present a query on ordered
structures which is definable in BPFO but not in monadic second-order logic,
and a query on additive structures which is definable in BPFO but not in FO.
The latter of these queries shows that certain uniform variants of AC0
(bounded-depth polynomial sized circuits) cannot be derandomised. These results
are in contrast to the general belief that most standard complexity classes can
be derandomised. Finally, we note that BPIFP+C, the probabilistic version of
fixed-point logic with counting, captures the complexity class BPP, even on
unordered structures
Positron Emission Tomography Score Has Greater Prognostic Significance Than Pretreatment Risk Stratification in Early-Stage Hodgkin Lymphoma in the UK RAPID Study.
PURPOSE: Accurate stratification of patients is an important goal in Hodgkin lymphoma (HL), but the role of pretreatment clinical risk stratification in the context of positron emission tomography (PET) -adapted treatment is unclear. We performed a subsidiary analysis of the RAPID trial to assess the prognostic value of pretreatment risk factors and PET score in determining outcomes. PATIENTS AND METHODS: Patients with stage IA to IIA HL and no mediastinal bulk underwent PET assessment after three cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine; 143 PET-positive patients (PET score, 3 to 5) received a fourth doxorubicin, bleomycin, vinblastine, and dacarbazine cycle and involved-field radiotherapy, and 419 patients in complete metabolic remission were randomly assigned to receive involved-field radiotherapy (n = 208) or no additional treatment (n = 211). Cox regression was used to investigate the association between PET score and pretreatment risk factors with HL-specific event-free survival (EFS). RESULTS: High PET score was associated with inferior EFS, before (P .4). CONCLUSION: In RAPID, a positive PET scan did not carry uniform prognostic weight; only a PET score of 5 was associated with inferior outcomes. This suggests that in future trials involving patients without B symptoms or mediastinal bulk, a score of 5 rather than a positive PET result should be used to guide treatment escalation in early-stage HL
Credimus
We believe that economic design and computational complexity---while already
important to each other---should become even more important to each other with
each passing year. But for that to happen, experts in on the one hand such
areas as social choice, economics, and political science and on the other hand
computational complexity will have to better understand each other's
worldviews.
This article, written by two complexity theorists who also work in
computational social choice theory, focuses on one direction of that process by
presenting a brief overview of how most computational complexity theorists view
the world. Although our immediate motivation is to make the lens through which
complexity theorists see the world be better understood by those in the social
sciences, we also feel that even within computer science it is very important
for nontheoreticians to understand how theoreticians think, just as it is
equally important within computer science for theoreticians to understand how
nontheoreticians think
Gonzalez v. Douglas Trial Transcript of Proceedings, Day 2
Gonzalez v. Dougla
Reporting Outcomes of Extremely Preterm Births
Published reports of extremely preterm birth outcomes provide important information to families, clinicians, and others and are widely used to make clinical and policy decisions. Misreporting or misunderstanding of outcome reports may have significant consequences. This article presents 7 recommendations to improve reporting of extremely preterm birth outcomes in both the primary and secondary literature. The recommendations should facilitate clarity in communication about extremely preterm birth outcomes and increase the value of existing and future work in this area
On Second-Order Monadic Monoidal and Groupoidal Quantifiers
We study logics defined in terms of second-order monadic monoidal and
groupoidal quantifiers. These are generalized quantifiers defined by monoid and
groupoid word-problems, equivalently, by regular and context-free languages. We
give a computational classification of the expressive power of these logics
over strings with varying built-in predicates. In particular, we show that
ATIME(n) can be logically characterized in terms of second-order monadic
monoidal quantifiers
- …