6 research outputs found
Le FORUM, Vol. 38 No. 1
https://digitalcommons.library.umaine.edu/francoamericain_forum/1040/thumbnail.jp
Le FORUM, Vol. 38 No. 2
https://digitalcommons.library.umaine.edu/francoamericain_forum/1041/thumbnail.jp
Le FORUM, Vol. 38 No. 3
https://digitalcommons.library.umaine.edu/francoamericain_forum/1042/thumbnail.jp
Le FORUM, Vol. 39 No. 2
https://digitalcommons.library.umaine.edu/francoamericain_forum/1045/thumbnail.jp
Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity
The nematode Caenorhabditis elegans is central to research in molecular, cell, and developmental biology, but nearly all of this research has been conducted on a single strain. Comparatively little is known about the population genomic and evolutionary history of this species. We characterized C. elegans genetic variation by high-throughput selective sequencing of a worldwide collection of 200 wild strains, identifying 41,188 single nucleotide polymorphisms. Unexpectedly, C. elegans genome variation is dominated by a set of commonly shared haplotypes on four of the six chromosomes, each spanning many megabases. Population-genetic modeling shows that this pattern was generated by chromosome-scale selective sweeps that have reduced variation worldwide; at least one of these sweeps likely occurred in the past few hundred years. These sweeps, which we hypothesize to be a result of human activity, have dramatically reshaped the global C. elegans population in the recent past