Safety performance assessment of food industry facilities using a fuzzy approach

The latest EU policies focus on the issue of food safety with a view to assuring adequate and standard quality levels for the food produced and/or consumed within the EC. To that purpose, the environment where agricultural products are manufactured and processed plays a crucial role in achieving food hygiene. As a consequence, it is of the utmost importance to adopt proper building solutions which meet health and hygiene requirements and to use suitable tools to measure the levels achieved. Similarly, it is necessary to verify and evaluate the level of safety and welfare of the workers in their working environment. The safety of the workers has not only an ethical and social value but also an economic implication, since possible accidents or environmental stressors are the major causes of the lower efficiency and productivity of workers. However, the technical solutions adopted in the manufacturing facilities in order to achieve adequate levels of safety and welfare of the workers are not always consistent with the solutions aimed at achieving adequate levels of food hygiene, even if both of them comply with sectoral rules which are often unconnected with each other. Therefore, it is fundamental to design suitable models of analysis that allow assessing buildings as a whole, taking into account both health and hygiene safety as well as the safety and welfare of workers. Hence, this paper proposes an evaluation model that, based on an established study protocol and on the application of a fuzzy logic procedure, allows evaluating the global safety level of a building. The proposed model allows to obtain a synthetic and global value of the building performance in terms of food hygiene and safety and welfare of the workers as well as to highlight possible weaknesses. Though the model may be applied in either the design or the operational phase of a building, this paper focuses on its application to certain buildings already operational in a specific productive context

Seismotectonics of the active thrust front in southwestern Sicily: hints on the Belice and Selinunte seismogenic sources

We present a seismotectonic model of the active thrust front in western Sicily, which includes the area hit by the 1968 Belice earthquake sequence. The ~40 km long South-WEstern Sicilian Thrust (SWEST) is formed by two aligned albeit non-parallel fault arrays, the Granitola-Castelevetrano Thrust System (GCTS) in the west and the Partanna- Poggioreale Thrust System (PPTS) in the east. The ~NE-SW trending, NW-dipping GCTS straddles from the Pelagian coastline to Castelvetrano, is ~18 km long and composed of two segments, with the northern, ~12 km long one showing geodetic and geologic evidence of active deformation (Barreca et al., 2014). The segment is marked by a sharp gradient in Differential SAR interferometry (DinSAR and STAMPs) and GPS velocity fields. Geologic evidence include an up to 60 m high, and up to 15° steep scarp, which is the fore-limb of a broad fold involving Lower Pleistocene shore calcarenites, and cm-scale reverse displacement of an ancient road dated as early Bronze-Hellenistic age. Inversion of fault slip-lineation data from structures displacing the archaeological remains yields a ~N110°E shortening axis, consistent with the geodetic shortening direction estimated from GPS differential velocities. The ~ENE-WSW trending PPTS stretches from Partanna to the macro-seismic area of the 1968 earthquake sequence and is composed of two ~10 km long segments limited by relay ramps. Although geologic and geodetic evidence of deformation are less clear than for the GCTS, we nonetheless observe a gradient in interferometry data for the western segment, and evidence of slow deformation (creep?) in historical to recent (last ~400 yr?) man-made structures. Integration of geologic, geodetic and seismology data suggests the active folds and thrusts are the uppermost expression of steep (45°) crustal ramps (Monaco et al., 1996) which upthrust the Saccense platform at depth. Based on macroseismic and seismological evidence (Monaco et al., 1996), we contend that the PPTS was partly activated during the 1968 sequence, and that rupture stopped at the junction with the GCTS. The current geodetic strain accumulation on the GCTS, on the other hand, suggests that the fault array has been significantly loaded, and that its last important co-seismic event could have been caused the 4th–5th century A.D. destruction of Selinunte (Bottari et al., 2009)

Electron transport through single Mn12 molecular magnets

We report transport measurements through a single-molecule magnet, the Mn12 derivative [Mn12O12(O2C-C6H4-SAc)16(H2O)4], in a single-molecule transistor geometry. Thiol groups connect the molecule to gold electrodes that are fabricated by electromigration. Striking observations are regions of complete current suppression and excitations of negative differential conductance on the energy scale of the anisotropy barrier of the molecule. Transport calculations, taking into account the high-spin ground state and magnetic excitations of the molecule, reveal a blocking mechanism of the current involving non-degenerate spin multiplets.Comment: Accepted for Phys. Rev. Lett., 5 pages, 4 figure

Polyphenol characterization and skin-preserving properties of hydroalcoholic flower extract from Himantoglossum robertianum (Orchidaceae)

Himantoglossum robertianum (Loisel.) P. Delforge is a Mediterranean orchid whose propagation in vitro has been achieved, making it eligible as a source of bioactive substances. Flowers were analyzed by light and SEM microscopy and used to obtain a polyphenol-rich, hydroalcoholic flower extract (HFE). HFE was characterized for total phenols, flavonoids and proanthocyanidins, and for polyphenol profile by RP-LC-DAD. Antioxidant assays, in vitro collagenase and elastase inhibition, and MTT and cell motility assays on HaCaT keratinocytes were done. Microscopy showed epidermal cells containing anthocyanins in the flower labellum. Flavonoids (flavones and flavan-3-ols) represented the most abundant compounds (42.91%), followed by scopoletin (33.79%), and phenolic acids (23.3%). Antioxidant assays showed strong activities, rating ORAC > FRAP > TEAC > \u3b2-carotene bleaching > DPPH > iron-chelation. Biological assays showed elastase and collagenase inhibition (up to 42% and 78%, respectively), improvement of HaCaT cell viability after treatment with 500 \u3bcM H2O2 (from 30% to 84% of control), and stimulation of cell migration rate up to 210% of control. In summary, HFE counteracted different free radicals, while protective properties were shown by cell-free and cell-based bioassays, suggesting the possible use of H. robertianum flowers for skin-preserving, repair, and anti-aging applications

Expectations and outcomes when moving from open to laparoscopic adrenalectomy: Multivariate analysis

Various authors have suggested that laparoscopic adrenalectomy (LA) leads to better surgical outcomes than open surgery. The debate is still open, however, and indications and limitations of minimally invasive surgery have not been completely established. The objective of our study was to compare surgical outcomes of LA and open adrenalectomy (OA), using multivariate analysis to adjust for potential confounding factors (e.g., size of the lesion, histology). Between 1995 and June 2000 at "Careggi" Hospital in Florence, Italy patients with an indication for adrenalectomy were treated laparoscopically if the lesion was 2 hours, blood loss greater than or equal to 500 ml) between patients operated on through a traditional approach and those who underwent LA. On the other hand, patients operated on laparoscopically have a significantly higher probability than the OA group of experiencing a better recovery from surgery (i.e., require less postoperative analgesics and return to normal activities earlier). The results of the present study show that, although LA does not add much benefit in terms of expected intraoperative outcomes, it dramatically speeds patients' recovery from surgery. The two approaches are complementary and should both be integrated into the technical background of all endocrine surgeons

Computational and synthetic approaches for the discovery of HIV-1 integrase inhibitors

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Botanical sources, chemistry, analysis, and biological activity of furanocoumarins of pharmaceutical interest

The aim of this work is to provide a critical review of plant furanocoumarins from different points of view, including their chemistry and biosynthetic pathways to their extraction, analysis, and synthesis, to the main biological activities found for these active compounds, in order to highlight their potential within pharmaceutical science. The limits and the possible improvements needed for research involving these molecules are also highlighted and discussed