Brain Monitoring: Do We Need a Hole? An Update on Invasive and Noninvasive Brain Monitoring Modalities

The ability to measure reliably the changes in the physical and biochemical environment after a brain injury is of great value in the prevention, treatment, and understanding of the secondary injuries. Three categories of multimodal brain monitoring exist: direct signals which are monitored invasively; variables which may be monitored noninvasively; and variables describing brain pathophysiology which are not monitored directly but are calculated at the bedside by dedicated computer software. Intracranial pressure (ICP) monitoring, either as stand-alone value or study of a dynamic trend, has become an important diagnostic tool in the diagnosis and management of multiple neurological conditions. Attempts have been made to measure ICP non-invasively, but this is not a clinical reality yet. There is contrasting evidence that monitoring of ICP is associated with better outcome, and further RCTs based on management protocol are warranted. Computer bedside calculation of “secondary parameters” has shown to be potentially helpful, particularly in helping to optimize “CPP-guided therapy.” In this paper we describe the most popular invasive and non invasive monitoring modalities, with great attention to their clinical interpretation based on the current published evidence

Observation of a New Fluxon Resonant Mechanism in Annular Josephson Tunnel Structures

A novel dynamical state has been observed in the dynamics of a perdurbed sine-Gordon system. This resonant state, has been experimentally observed as a singularity in the dc current voltage characteristic of an annular Josephson tunnel junction, excited in the presence of a magnetic field. With this respect, it can be assimilated to self-resonances known as Fiske steps. Differently from these, however, we demonstrate, on the basis of numerical simulations, that its detailed dynamics involves rotating fluxon pairs, a mechanism associated, so far, to self-resonances known as zero-field steps.Comment: 4 pages, 2 figures, submitted to Physical Review Letter

Diagnostics for specific PAHs in the far-IR: searching neutral naphthalene and anthracene in the Red Rectangle

Context. In the framework of the interstellar polycyclic aromatic hydrocarbons (PAHs) hypothesis, far-IR skeletal bands are expected to be a fingerprint of single species in this class. Aims. We address the question of detectability of low energy PAH vibrational bands, with respect to spectral contrast and intensity ratio with ``classical'' Aromatic Infrared Bands (AIBs). Methods. We extend our extablished Monte-Carlo model of the photophysics of specific PAHs in astronomical environments, to include rotational and anharmonic band structure. The required molecular parameters were calculated in the framework of the Density Functional Theory. Results. We calculate the detailed spectral profiles of three low-energy vibrational bands of neutral naphthalene, and four low-energy vibrational bands of neutral anthracene. They are used to establish detectability constraints based on intensity ratios with ``classical'' AIBs. A general procedure is suggested to select promising diagnostics, and tested on available Infrared Space Observatory data for the Red Rectangle nebula. Conclusions. The search for single, specific PAHs in the far-IR is a challenging, but promising task, especially in view of the forthcoming launch of the Herschel Space Observatory.Comment: 13 pages, 13 figures, accepted for publication in A&

Analytic continuation of the Hurwitz Zeta Function with physical application

A new formula relating the analytic continuation of the Hurwitz zeta function to the Euler gamma function and a polylogarithmic function is presented. In particular, the values of the first derivative of the real part of the analytic continuation of the Hurwitz zeta function for even negative integers and the imaginary one for odd negative integers are explicitly given. The result can be of interest both on mathematical and physical side, because we are able to apply our new formulas in the context of the Spectral Zeta Function regularization, computing the exact pair production rate per space-time unit of massive Dirac particles interacting with a purely electric background field.Comment: Replaced version, minor changes. 9 pages, to be published in J. Math. Phy

Localization of Gauge Fields and Monopole Tunnelling

We study the dynamical localization of a massless gauge field on a lower-dimensional surface (2-brane). In flat space, the necessary and sufficient condition for this phenomenon is the existence of confinement in the bulk. The resulting configuration is equivalent to a dual Josephson junction. This duality leads to an interesting puzzle, as it implies that a localized massless theory, even in the Abelian case, must become confining at exponentially large distances. Through the use of topological arguments we clarify the physics behind this large-distance confinement and identify the instantons of the brane world-volume theory that are responsible for its appearance. We show that they correspond to the (condensed) bulk magnetic charges (monopoles), that occasionally tunnel through the brane and induce weak confinement of the brane theory. We consider the possible generalization of this effect to higher dimensions and discuss phenomenological bounds on the confinement of electric charges at exponentially large distances within our Universe.Comment: 11 pages, 3 figures, improvements in the presentation, version to appear in Physical Review

Spin analog of the controlled Josephson charge current

We propose a controlled Josephson spin current across the junction of two non-centrosymmetric superconductors like CePt_3Si. The Josephson spin current arises due to direction dependent tunneling matrix element and different momentum dependent phases of the triplet components of the gap function. Its modulation with the angle \xi between the noncentrosymmetric axes of two superconductors is proportional to \sin \xi. This particular dependence on \xi may find application of the proposed set-up in making a Josephson spin switch.Comment: 4 pages, 1 figure; title is changed; article is rewritte

Observation of mesoscopic conductance fluctuations in YBaCuO grain boundary Josephson Junctions

Magneto-fluctuations of the normal resistance R_N have been reproducibly observed in high critical temp erature superconductor (HTS) grain boundary junctions, at low temperatures. We attribute them to mesoscopic transport in narrow channels across the grain boundary line. The Thouless energy appears to be the relevant energy scale. Our findings have significant implications on quasiparticle relaxation and coherent transport in HTS grain boundaries.Comment: Revised version, minor changes. 4 pages, 4 figure

Josephson junctions in thin and narrow rectangular superconducting strips

I consider a Josephson junction crossing the middle of a thin rectangular superconducting strip of length L and width W subjected to a perpendicular magnetic induction B. I calculate the spatial dependence of the gauge-invariant phase difference across the junction and the resulting B dependence of the critical current Ic(B).Comment: 4 pages, 6 figures, revised following referee's comment

AC Josephson effect and resonant Cooper pair tunneling emission of a Cooper Pair Transistor

We measure the high-frequency emission of a single Cooper pair transistor(SCPT) in the regime where transport is only due to tunneling of Cooper pairs. This is achieved by coupling on-chip the SCPT to a superconductor-insulator-superconductor junction and by measuring the photon assisted tunneling current of quasiparticles across the junction. This technique allows a direct detection of the AC Josephson effect of the SCPT and provides evidence of Landau-Zener transitions for proper gate voltage. The emission in the regime of resonant Cooper pair tunneling is also investigated. It is interpreted in terms of transitions between charge states coupled by the Josephson effect.Comment: Revtex4, 5 pages, 4 figures, final versio

Drafting a prioritized checklist of Crop Wild Relatives and Wild Harvested Plants of Italy: problems and solutions

The National checklists of Crop Wild Relatives (CWR) and Wild Harvested Plants (WHP) are the basic tools for the development of in situ and ex situ conservation strategies of plant genetic resources. Here we discuss the methodologies and the prioritization process we previously used in the preparation of the prioritized checklist of CWR and WHP for Italy. The starting point were the most up-to-date Italian checklists of native and alien flora with their updates used as a nomenclatural and distributive source of data. Sardinia and Sicily were kept separate from peninsular Italy to perform detailed analyses focused on the taxa of the two major islands. The origin, the endemic status, cultivation, economic importance, uses, gene pool or taxon group, and the Red List status information were added. The WHP status was attributed to all the taxa with known direct uses. A qualitative approach was adopted in the prioritization process, the main criteria used were: 1) the inclusion of wild relative taxa of crops listed in Annex I of the International Treaty on Plant Genetic Resources for Food and Agriculture (ITPGRFA) and/or by the Italian Institute of Statistics (ISTAT) for cultivated areas and yield in the last 5 years; 2) the threatened taxa occurring in national or global Red lists; 3) the endemism. This prioritization process generated 102 taxa as most in need of specific protection and /or monitoring measures, 57 taxa requiring monitoring because of their restricted distribution although not requiring specific protection measures and 735 taxa not requiring any specific protection. However, different prioritization processes could have been applied to the Italian checklists yielding different results. Here we discuss the matter