Verflechtungen im städtischen Gefüge: Rezension zu Barbara Heer (2019): Cities of entanglements. Social life in Johannesburg and Maputo through ethnographic comparison. Bielefeld: transcript.

Dieser Artikel rezensiert die überarbeitete Version von Barbara Heers Dissertation zu städtischen Verflechtungen in Johannesburg und Maputo. Das Buch ist 2019 im Transcript Verlag erschienen und umfasst 337 Seiten.This article reviews the revised version of Barbara Heer's dissertation on urban entanglements in Johannesburg and Maputo. It was published by Transcript Publishing in 2019 and comprises 337 pages

Redesign da interface para um sistema de gestão financeira

PCC(graduação) - Universidade Federal de Santa Catarina. Centro de Comunicação e Expressão. Design.Este Projeto de Conclusão de Curso apresenta o processo de redesign de um sistema de gestão financeira voltado para micro e pequenas empresas em especial do ramo do varejo. Para tanto, adotou-se a metodologia de Garrett (2011) para propor uma revisão crítica desde o arranjo de informações, até a sua apresentação gráfica, bem como propor uma versão responsiva para utilização em dispositivos mobile. A partir das etapas de desenvolvimento metodológico propostas pelo autor supracitado, foi possível compreender o contexto de uso, adaptando o sistema já existente e testando as soluções encontradas para uma melhor, mais ágil e agradável experiência dos usuários.This Report presents the process of redesign for a financial management system geared towards micro and small enterprises, especially in the retail sector. Therefore, the methodology of Garrett (2011) was adopted to propose a critical analysis from the arrangement of information, to the graphic presentation, as well as to propose a responsive version for use in mobile devices. Using the methodological development stages proposed by the above-mentioned author, it was possible to understand the context of use, adapting the existing system, and testing the solutions found, for a better, more agile and pleasant user experience

Fecal Microbiota Transplant in a patient with multi-drug resistant clostridium difficile (MDR C.diff)

Introduction: Studies have shown MDR C. diff is the most common bacterial cause of diarrhea in resource rich settings. One of the most feared outcome of MDR C. diff infection is pseudomembranous colitis. Multiple studies indicate FMT is the most effective yet underutilized in treating recurrent C. diff. Case report: A 73 year old man presented with complaints of diarrhea and fever of 3 days duration. The diarrhea was watery, voluminous, and up to 10 times per day with associated abdominal discomfort. Patient was hospitalized twice in the last 2 months for similar complaints which were treated with oral antibiotics. On physical examination: Temperature 99.5 B/P 161/86 HR 114 and RR 20. Abdominal distention, mild tenderness and hyperactive bowel sounds. Cardiac and chest exams were unremarkable. Laboratory were significant for hypokalemia, elevated BUN and creatinine, lactic acidosis and leukocytosis. C. diff enzyme immune assay was positive for C. diff antigen and C. diff toxins A+B. Upon admission to the floor, IV fluid and electrolyte replacement began. A 10 day antibiotics regimen showed no clinical improvement. The patient’s son donated stool, and two rounds of FMT were administered via colonoscopy; improving patient’s clinical condition. Resolving leukocytosis and electrolyte abnormalities. Conclusion: FMT is strongly suggested in patients with MDR C. diff as it decreases fatal complications and hospital readmission

Meeting Need

This article considers the question ‘How should institutions enable people to meet their needs in situations where there is no guarantee that all needs can be met?’ After considering and rejecting several simple principles for meeting needs, it suggests a new effectiveness principle that (1) gives greater weight to the needs of the less well off and (2) gives weight to enabling a greater number of people to meet their needs. The effectiveness principle has some advantage over the main competitors including a principle suggested by David Miller in Principles of Social Justice. Miller argues that his principle accounts for the existing data on individuals\u27 intuitions about meeting needs. The effectiveness principle better accounts for this data. Furthermore, this article presents a new experiment on intuitions about meeting need that is consistent with the effectiveness principle but not Miller\u27s principle

Prion protein in the cerebrospinal fluid of healthy and naturally scrapie-affected sheep

The aim of this study was to characterize the cerebrospinal fluid (CSF) prion protein (PrP) of healthy and naturally scrapie-affected sheep. The soluble form of CSF PrPC immunoblotted with an anti-octarepeat and an anti-C terminus mAb showed two isoforms of approximately 33 and 26 kDa, corresponding to the biglycosylated and unglycosylated isoforms of brain PrPC. Neither the mean concentration nor the electrophoretic profile of CSF PrP differed between healthy and scrapieaffected sheep, whereas a slightly increased resistance of CSF PrP to mild proteolysis by proteinase K was evident in the CSF of scrapie-affected sheep. No difference in susceptibility to proteolysis was observed between the two ARR and VRQ genetic variants of the purified prokaryote recombinant PrP. It was concluded that the physicochemical properties of PrPC in the CSF could be altered during scrapie and that these changes might reflect the physiopathological process of prion disease

Repeated Maximal Exercise Measures are Very Reliable Among Healthy College-aged Individuals

The most common way to assess cardiovascular fitness is with a maximal graded exercise test (GXT) to determine the maximal rate of oxygen consumption (VO2 max). Maximal exercise efforts during GXT testing have been shown to be quite repeatable among active and sedentary adults, as well as cardiac patients and the elderly. With young, healthy participants, familiarization and motivation could result in improved performance measures with repeated testing. The reliability of maximal exercise measures among healthy college-aged individuals during repeated Bruce Protocol GXT assessments are yet unclear. PURPOSE: To determine how repeatable the VO2max and other maximal exercise indices were with repeated GXT measures among healthy, college-aged adults. METHODS: Thirty-six apparently healthy participants (20 men, 16 women) aged 21.47 ± 0.5 years completed three GXT testing sessions following the Bruce Protocol. The maximal values for VO2, blood lactate, VE, HR and Borg Rating of Perceived Exertion (RPE) as well as time to exhaustion were recorded at the end of each session. RESULTS: Statistical analysis of the data was conducted using a one-way ANOVA by order of visit and a Tukey post-hoc analysis. With all participants combined, there were no differences in measured variables with one exception. Maximal RPE was higher in Visit 3 compared to Baseline (p=0.02). When men and the women were analyzed separately, there were no differences in RPE values among the men. Women reported a higher Max RPE in both Visit 2 and Visit 3 compared to Baseline. Despite the higher RPE values no other maximal measures were significantly different across testing sessions. CONCLUSION: This research confirms that repeated maximal GXT measures are very reliable among healthy college-aged individuals. The exception being a small but significant difference in self-reported maximal RPE values among women compared to baseline measures. Future studies could address potential reasons for the significant difference in women’s self-reported RPE values

Effects of single-dose injectable paracetamolversus propacetamol in pain management after minor gynecologic surgery: A multicenter, randomized, double-blind, active-controlled, two-parallel-group study

AbstractBackground:Intravenous administration is the route of choice for drug therapy in the immediate postoperative period. Propacetamol (ProAPAP), an injectable prodrug of paracetamol requiring reconstitution, has demonstrated efficacy in managing acute pain and fever. However, it has been associated with pain at the injection site. A stable, ready-to-use formulation of paracetamol solution infused intravenously (IV-APAP) has been developed and might be associated with less pain at the injection site compared with ProAPARObjective:The objective of this study was to assess the tolerability and efficacy of a single dose of IV APAP 1 g compared with those of a single dose of ProAPAP 2 g in patients with moderate to severe pain after minor gynecologic surgery.Methods:This single-dose, randomized, double-blind, active-controlled,2-parallel-group study was conducted at 23 hospitals and outpatient clinics in France. After minor gynecologic surgery, patients reporting moderate to severe pain were randomized to receive a single 15-minute infusion of IV-APAP 1 g or ProAPAP 2 g (bioeyuivalent doses). Tolerability was monitored using local and systemic adverse event (AE) reporting, clinical examination including vital sign measurement, and patients' ratings of acceptability of the infusion. Efficacy end points included pain intensity at 0, 1, 2, 4, and 6 hours; median time to rescue medication (defined as the time at which 50% of patients requested rescue medication); and percentage of patients requesting rescue medication. Patients' satisfaction with the study drugs was assessed using patient's global evaluation (PGE) and the percentage of patients willing to receive the treatment again.Results:Of the 163 women who were randomized, 161 received the studymedication. The IV-APAP group comprised 80 patients (mean [SD] age, 38.3 [12.8] years [range, 18.0-69.0 years]; mean [SD] weight, 61.1 [11.0] kg [range, 49.0–90.0 kg]), and the ProAPAP group comprised 81 patients (mean [SD] age, 33.9 [12.0] years [range, 18.0–67.0 years]; mean [SD] weight, 61.6 [10.2] kg [range, 42.0–95.5 kg]); the difference in mean age between the 2 groups was statistically significant (P < 0.05). The incidence of local treatment-emergent AEs (TEAEs) was significantly lower in the IV-APAP group compared with that in the ProAPAP group (7.5% vs 38.3%; P < 0.001). No between-group differences in the incidence of systemic TEAEs was found. All patients in the IV-APAP group found the infusion tolerable, compared with 95% of patients in the ProAPAP group. The median time to rescue medication was not evaluated because <50% of the patients in each group requested it. No significant differences in mean pain intensity score or percentage of patients requesting rescue medication were found between the 2 groups at any time point. The percentages of patients in the IV-APAP and ProAPAP groups who rated the study medication as good or excellent on the PGE (83.6% vs 75.6%; P < 0.05) and who were willing to receive the same treatment again (96.0% vs 81.0%; P = 0.005) were significantly higher with IV-APAP compared with ProAPAPConclusion:In these patients with moderate to severe pain after minor gynecologic surgery, a single dose of IV-APAP was associated with better local tolerability, similar analgesic efficacy, and greater patient satisfaction compared with a single bioequivalent dose of ProAPAP

Low T-cell chimerism is not followed by graft rejection after nonmyeloablative stem cell transplantation (NMSCT) with CD34-selected PBSC.

peer reviewedWe investigate the feasibility of CD34-selected peripheral blood stem cell (PBSC) transplantation followed by pre-emptive CD8-depleted donor lymphocyte infusions (DLI) after a minimal conditioning regimen. Six patients with advanced hematological malignancies ineligible for a conventional myeloablative transplant (n=5) or metastatic renal cell carcinoma (n=1), and with an HLA-identical (n=4) or alternative (n=2) donor were included. The nonmyeloablative conditioning regimen consisted in 2 Gy TBI alone (n=4), 2 Gy TBI and fludarabine (RCC patient, n=1) or cyclophosphamide and fludarabine (patient who had previously received 12 Gy TBI, n=1). Post transplant immunosuppression was carried out with cyclosporin (CyA) and mycophenolate mofetil (MMF). Initial engraftment was achieved in all patients. One out of six patients (17%) experienced grade > or =2 acute GVHD only after abrupt cyclosporin discontinuation and alpha interferon therapy for life-threatening tumor progression. T-cell chimerism was 23% (19-30) on day 28, 32% (10-35) on day 100, 78% (49-95) on day 180 and 99.5% (99-100) on day 365. Three out of four patients who had measurable disease before the transplant experienced a complete response. We conclude that CD34-selected NMSCT followed by CD8-depleted DLI is feasible and preserves engraftment and apparently also the graft-versus-leukemia (GVL) effect. Further studies are needed to confirm this encouraging preliminary report

Charting the endometrial cancer care pathway : a baseline audit

Introduction: Longer waiting times from diagnosis to surgical resection have been found to negatively impact the overall survival and quality of life of women with endometrial cancer. The Cancer Care Pathway Directorate adopted the UK National Waiting Times Monitoring Dataset Guidance, to improve the timeliness of services along the cancer care pathway. From this, three key targets were identified: 1) Maximum 14-day wait from urgent GP referral for suspected cancer to first outpatient attendance (operational standard of 93%), 2) Maximum 31-day wait from decision to treat to first definitive treatment (operational standard of 96%), and 3) Maximum 62-day wait from urgent GP referral for suspected cancer to first treatment (operational standard of 85%). The aim of this baseline audit was to chart the time-frames of the various stages in the endometrial cancer pathway of patients diagnosed with this disease between 2015 and 2016 to assess for and identify delays in referral, investigation and care. -- Methods: A tool was developed following consultation with key stakeholders. Data protection clearance was obtained. Patient medical and oncology files, hospital databases, and MDT documentation for confirmed endometrial cancer cases were reviewed between September 2017 – March 2018. -- Results: A total of 101 endometrial cancer cases were included in the audit. The proportion of cases which met the 14-day, 31-day and 62-day wait KPIs operational standards were 39.1%, 81.2% and 17.2% respectively. -- Conclusion: The endometrial cancer care pathway timeframes did not meet the KPIs operational standards. Fast-track coordinators and nurse navigators could improve continuity and coordination of patient care.peer-reviewe

Where on the face do we look during phonemic restoration: An eye-tracking study

Face to face communication typically involves audio and visual components to the speech signal. To examine the effect of task demands on gaze patterns in response to a speaking face, adults participated in two eye-tracking experiments with an audiovisual (articulatory information from the mouth was visible) and a pixelated condition (articulatory information was not visible). Further, task demands were manipulated by having listeners respond in a passive (no response) or an active (button press response) context. The active experiment required participants to discriminate between speech stimuli and was designed to mimic environmental situations which require one to use visual information to disambiguate the speaker’s message, simulating different listening conditions in real-world settings. Stimuli included a clear exemplar of the syllable /ba/ and a second exemplar in which the formant initial consonant was reduced creating an /a/−like consonant. Consistent with our hypothesis, results revealed that the greatest fixations to the mouth were present in the audiovisual active experiment and visual articulatory information led to a phonemic restoration effect for the /a/ speech token. In the pixelated condition, participants fixated on the eyes, and discrimination of the deviant token within the active experiment was significantly greater than the audiovisual condition. These results suggest that when required to disambiguate changes in speech, adults may look to the mouth for additional cues to support processing when it is available