Synthesis, characterization and in vitro biological evaluation of some new diarylsulfonylurea-chalcone hybrids as potential 5-lipoxygenase inhibitors

A series of some new diarylsulfonylurea-chalcone hybrids (4a-4y) have been synthesized via Claisen-Schmidt condensation reaction by treating 1-(3-acetylphenyl)-3-tosylurea with various aromatic/heteroaromatic aldehydes in the presence of alkali and characterized by FT-IR, 1H NMR, 13C NMR and LC mass spectral analysis. All the synthesized compounds were evaluated for their in vitro 5-Lipoxygenase inhibitory activity using potato 5-lipoxygenase enzyme. Among the tested compounds 4r and 4o exhibited significant inhibitory activity at IC50 values 7.88±0.14 and 11.77±0.21 µg/mL, respectively. This level of activity was found comparable to that of the reference drug Abietic acid (LI01020) with IC50 value 4.34±0.37 µg/mL and it could be a remarkable starting point to develop new lead molecules

The International Planetary Data Alliance: Progress and vision for the next decade

International audienceIn the mid-1980s, as NASA planetary exploration expanded, it became apparent that a national archive that could handle digitized data was needed. NASA launched the Planetary Data System (PDS) in 1989 after considerable planning and development. Because most of the early planetary data originated from NASA missions, the international scientific community became familiar with PDS standards. Thus, when the European Space Agency (ESA) began producing planetary science data they adopted components of the PDS standards and developed the Planetary Science Archive (PSA). This occurred under version 3 (PDS3) of the PDS Standards.The PDS and PSA worked closely together to develop standards and share data. As additional agencies began developing unique missions of interest to the international community, two needs were identified: increased cooperation and collaboration to facilitate access to the individual archives, and modernization and implementation of standards. A group of individuals involved in mission archiving within the international planetary community met in 2006 to develop a mechanism for enhancing international access and collaboration [1]. The goal of this meeting was to develop an approach that would: 1) Give scientific communities world-wide access to data archives built upon similar standards; 2) Reduce cost of archiving and distributing science data by collaborating and sharing standards; 3) Ensure reusability of science data across agency/mission/instrument boundaries; 4) Coordinate archiving processes and plans; and 5) Improve and increase access to tools and services offered.As a result of these interactions, the International Planetary Data Alliance (IPDA) was founded. Over the past decade, the IPDA has grown significantly, with shared projects focused on achieving the goals. Over twelve agencies have joined the IPDA and participate in the Steering Committee. These agencies have supported a major upgrade of the Planetary Data System standards called "PDS4". NASA and ESA are now operationally using PDS4 and all future planetary missions are adopting or planning to adopt it for archiving their data. Over the next decade, this will lay a foundation by which improved and increased access, tools, and services can be realized at a global scale. This talk will provide an overview of the IPDA and discuss opportunities to increase use, access, and interoperability as an international data science platform for planetary science research. [1] "Developing a Core Set of Data Standards for the IPDA", Concept White Paper, January 2007

The International Planetary Data Alliance (IPDA): Overview of the Activities

International audienceAn overview of activities of the IPDA is presented in the frame of the recently growing number of successful space experiments dedicated to planetary observation, with a significantly growing number of people involved in such activity and with significantly growing numbers of web services willing to share data and services in our research domain, but also, in close by domains such as astronomy, heliophysics and atmospheric sciences for the Earth. An overview of a number of space agencies and organizations is given. In total, IPDA consists of 13 national organizations: NASA (USA), CNES (France), ESA (Europe), STFC (UK), JAXA (Japan), ASI (Italy), ISRO (India), DLR (Germany), RKA (Russia), RCSA (China), FMI (Finland), ArSA (Armenia) and United Arab Emirates. Some projects of 2015 in frame of the IPDA activities are described