On Approaching the Ultimate Limits of Photon-Efficient and Bandwidth-Efficient Optical Communication

It is well known that ideal free-space optical communication at the quantum limit can have unbounded photon information efficiency (PIE), measured in bits per photon. High PIE comes at a price of low dimensional information efficiency (DIE), measured in bits per spatio-temporal-polarization mode. If only temporal modes are used, then DIE translates directly to bandwidth efficiency. In this paper, the DIE vs. PIE tradeoffs for known modulations and receiver structures are compared to the ultimate quantum limit, and analytic approximations are found in the limit of high PIE. This analysis shows that known structures fall short of the maximum attainable DIE by a factor that increases linearly with PIE for high PIE. The capacity of the Dolinar receiver is derived for binary coherent-state modulations and computed for the case of on-off keying (OOK). The DIE vs. PIE tradeoff for this case is improved only slightly compared to OOK with photon counting. An adaptive rule is derived for an additive local oscillator that maximizes the mutual information between a receiver and a transmitter that selects from a set of coherent states. For binary phase-shift keying (BPSK), this is shown to be equivalent to the operation of the Dolinar receiver. The Dolinar receiver is extended to make adaptive measurements on a coded sequence of coherent state symbols. Information from previous measurements is used to adjust the a priori probabilities of the next symbols. The adaptive Dolinar receiver does not improve the DIE vs. PIE tradeoff compared to independent transmission and Dolinar reception of each symbol.Comment: 10 pages, 8 figures; corrected a typo in equation 3

Activity-dependent dynamics and sequestration of proteasomes in dendritic spines

The regulated degradation of proteins by the ubiquitin proteasome pathway is emerging as an important modulator of synaptic function and plasticity. The proteasome is a large, multi-subunit cellular machine that recognizes, unfolds and degrades target polyubiquitinated proteins. Here we report NMDA (N-methyl-D-aspartate) receptor-dependent redistribution of proteasomes from dendritic shafts to synaptic spines upon synaptic stimulation, providing a mechanism for local protein degradation. Using a proteasome-activity reporter and local perfusion, we show that synaptic stimulation regulates proteasome activity locally in the dendrites. We used restricted photobleaching of individual spines and dendritic shafts to reveal the dynamics that underlie proteasome sequestration, and show that activity modestly enhances the entry rate of proteasomes into spines while dramatically reducing their exit rate. Proteasome sequestration is persistent, reflecting an association with the actin-based cytoskeleton. Together, our data indicate that synaptic activity can promote the recruitment and sequestration of proteasomes to locally remodel the protein composition of synapses

Signal-to-noise ratio of Gaussian-state ghost imaging

The signal-to-noise ratios (SNRs) of three Gaussian-state ghost imaging configurations--distinguished by the nature of their light sources--are derived. Two use classical-state light, specifically a joint signal-reference field state that has either the maximum phase-insensitive or the maximum phase-sensitive cross correlation consistent with having a proper $P$ representation. The third uses nonclassical light, in particular an entangled signal-reference field state with the maximum phase-sensitive cross correlation permitted by quantum mechanics. Analytic SNR expressions are developed for the near-field and far-field regimes, within which simple asymptotic approximations are presented for low-brightness and high-brightness sources. A high-brightness thermal-state (classical phase-insensitive state) source will typically achieve a higher SNR than a biphoton-state (low-brightness, low-flux limit of the entangled-state) source, when all other system parameters are equal for the two systems. With high efficiency photon-number resolving detectors, a low-brightness, high-flux entangled-state source may achieve a higher SNR than that obtained with a high-brightness thermal-state source.Comment: 12 pages, 4 figures. This version incorporates additional references and a new analysis of the nonclassical case that, for the first time, includes the complete transition to the classical signal-to-noise ratio asymptote at high source brightnes

LaB-GATr: geometric algebra transformers for large biomedical surface and volume meshes

Many anatomical structures can be described by surface or volume meshes. Machine learning is a promising tool to extract information from these 3D models. However, high-fidelity meshes often contain hundreds of thousands of vertices, which creates unique challenges in building deep neural network architectures. Furthermore, patient-specific meshes may not be canonically aligned which limits the generalisation of machine learning algorithms. We propose LaB-GATr, a transfomer neural network with geometric tokenisation that can effectively learn with large-scale (bio-)medical surface and volume meshes through sequence compression and interpolation. Our method extends the recently proposed geometric algebra transformer (GATr) and thus respects all Euclidean symmetries, i.e. rotation, translation and reflection, effectively mitigating the problem of canonical alignment between patients. LaB-GATr achieves state-of-the-art results on three tasks in cardiovascular hemodynamics modelling and neurodevelopmental phenotype prediction, featuring meshes of up to 200,000 vertices. Our results demonstrate that LaB-GATr is a powerful architecture for learning with high-fidelity meshes which has the potential to enable interesting downstream applications. Our implementation is publicly available

Classical capacity of bosonic broadcast communication and a new minimum output entropy conjecture

Previous work on the classical information capacities of bosonic channels has established the capacity of the single-user pure-loss channel, bounded the capacity of the single-user thermal-noise channel, and bounded the capacity region of the multiple-access channel. The latter is a multi-user scenario in which several transmitters seek to simultaneously and independently communicate to a single receiver. We study the capacity region of the bosonic broadcast channel, in which a single transmitter seeks to simultaneously and independently communicate to two different receivers. It is known that the tightest available lower bound on the capacity of the single-user thermal-noise channel is that channel's capacity if, as conjectured, the minimum von Neumann entropy at the output of a bosonic channel with additive thermal noise occurs for coherent-state inputs. Evidence in support of this minimum output entropy conjecture has been accumulated, but a rigorous proof has not been obtained. In this paper, we propose a new minimum output entropy conjecture that, if proved to be correct, will establish that the capacity region of the bosonic broadcast channel equals the inner bound achieved using a coherent-state encoding and optimum detection. We provide some evidence that supports this new conjecture, but again a full proof is not available.Comment: 13 pages, 7 figure